Patents by Inventor Deepali Prashar

Deepali Prashar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of covalently modifying proteins with organic molecules to prevent aggregation
    Patent number: 8569463
    Abstract: A system and method for preventing protein aggregation is developed by covalent modification of proteins with organic molecules that can preserve the native protein folding. Proteins are covalently modified with sugar alcohols or cyclodextrins (organic Kosmotropes) or other small molecule drugs by water-driven bioorganic reactions in water. In the water-driven bioorganic reactions, the reagent is stable in water and can modify lysine residues or cysteine residue of a protein at physiological conditions with high yield and fast rate. Proteins and antibodies will be modified by non-natural sugar alcohols. As a result, the efficacy of protein drugs (reduction in aggregation and enzymatic degradation, and increase in blood stream life time) may be improved.
    Type: Grant
    Filed: April 23, 2010
    Date of Patent: October 29, 2013
    Assignee: Syracuse University
    Inventors: Yan-Yeung Luk, DaWei Cui, Debjyoti Bandyopadhyay, Deepali Prashar, Preeti Sejwal, Karen Simon
  • METHOD OF COVALENTLY MODIFYING PROTEINS WITH ORGANIC MOLECULES TO PREVENT AGGREGATION
    Publication number: 20100273991
    Abstract: A system and method for preventing protein aggregation is developed by covalent modification of proteins with organic molecules that can preserve the native protein folding. Proteins are covalently modified with sugar alcohols or cyclodextrins (organic Kosmotropes) or other small molecule drugs by water-driven bioorganic reactions in water. In the water-driven bioorganic reactions, the reagent is stable in water and can modify lysine residues or cysteine residue of a protein at physiological conditions with high yield and fast rate. Proteins and antibodies will be modified by non-natural sugar alcohols. As a result, the efficacy of protein drugs (reduction in aggregation and enzymatic degradation, and increase in blood stream life time) may be improved.
    Type: Application
    Filed: April 23, 2010
    Publication date: October 28, 2010
    Applicant: SYRACUSE UNIVERSITY
    Inventors: Yan-Yeung Luk, DaWei Cui, Debjyoti Bandyopadhyay, Deepali Prashar, Preeti Sejwal, Karen Simon