Patents by Inventor Dehua Pei

Dehua Pei has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180030094
    Abstract: Disclosed herein are bicyclic peptide compounds, compositions comprising same, methods for making same, and libraries comprising same. The disclosed compounds, in various aspects, are useful for treating a variety of disorders, including inflammatory disorders, autoimmune disorders, and disorders of uncontrolled cellular proliferation. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: August 9, 2017
    Publication date: February 1, 2018
    Inventors: Dehua Pei, Punit Upadhyaya, Wenlong Lian, Thi Trinh
  • Patent number: 9868767
    Abstract: Disclosed herein are bicyclic peptide compounds, compositions comprising same, methods for making same, and libraries comprising same. The disclosed compounds, in various aspects, are useful for treating a variety of disorders, including inflammatory disorders, autoimmune disorders, and disorders of uncontrolled cellular proliferation. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: May 23, 2014
    Date of Patent: January 16, 2018
    Assignee: Ohio State Innovation Foundation
    Inventors: Dehua Pei, Punit Upadhyaya, Wenlong Lian, Thi Trinh
  • Publication number: 20170355730
    Abstract: Disclosed herein are compounds having activity as cell penetrating peptides. In some examples, the compounds can comprise a cell penetrating peptide moiety and a cargo moiety. The cargo moiety can comprise one or more detectable moieties, one or more therapeutic moieties, one or more targeting moieties, or any combination thereof. In some examples, the cell penetrating peptide moiety is cyclic. In some examples, the cell penetrating peptide moiety and cargo moiety together are cyclic. In some examples, the cell penetrating peptide moiety is cyclic and the cargo moiety is appended to the cyclic cell penetrating peptide moiety structure. In some examples, the cargo moiety is cyclic and the cell penetrating peptide moiety is cyclic, and together they form a fused bicyclic system.
    Type: Application
    Filed: November 23, 2016
    Publication date: December 14, 2017
    Inventors: Dehua PEI, Ziqing QIAN
  • Publication number: 20170304383
    Abstract: Disclosed herein are novel compounds that are Ras inhibitors. Also disclosed are compositions comprising the compounds and methods of using the compounds in treating various diseases. In another aspect, provided is an antibody-drug-conjugate comprising an antibody conjugated with a compound described herein. In still another aspect, provided is a pharmaceutical composition comprising a compound or antibody-drug-conjugate described herein. In a further aspect, provided is method of treating a cancer comprising administering a therapeutically effective amount of a compound or antibody-drug-conjugate described herein to a patient in need thereof.
    Type: Application
    Filed: May 19, 2015
    Publication date: October 26, 2017
    Inventors: Roger BRIESEWITZ, Dehua PEI, Punit UPADHYAYA
  • Publication number: 20170281723
    Abstract: Improved calcineurin inhibitors and methods of using these improved calcineurin inhibitors to inhibit calcineurin-NFAT signaling in cells and in subjects are disclosed.
    Type: Application
    Filed: August 27, 2015
    Publication date: October 5, 2017
    Inventors: Dehua Pei, Ziqing Qian
  • Publication number: 20170190743
    Abstract: Disclosed herein are compounds having activity as cell penetrating peptides. In some examples, the compounds can comprise a cell penetrating peptide moiety and a cargo moiety. The cargo moiety can comprise one or more detectable moieties, one or more therapeutic moieties, one or more targeting moieties, or any combination thereof. In some examples, the cell penetrating peptide moiety is cyclic. In some examples, the cell penetrating peptide moiety and cargo moiety together are cyclic. In some examples, the cell penetrating peptide moiety is cyclic and the cargo moiety is appended to the cyclic cell penetrating peptide moiety structure. In some examples, the cargo moiety is cyclic and the cell penetrating peptide moiety is cyclic, and together they form a fused bicyclic system.
    Type: Application
    Filed: May 21, 2015
    Publication date: July 6, 2017
    Inventors: Dehua PEI, Ziqing QIAN
  • Publication number: 20160333054
    Abstract: A method of inhibiting a binding event between a target protein and a binding protein, comprising administering to a cell in vitro an effective amount of a non-naturally occurring bifunctional inhibitor molecule including (a) protein binding moiety, and (b) an effector region, wherein the protein binding moiety binds to a blocking protein, and wherein the effector region binds to the target protein in order to bind the target protein and the blocking protein and prevent access of the binding protein to the target protein. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: August 1, 2016
    Publication date: November 17, 2016
    Inventors: Roger Briesewitz, Dehua Pei, Xianghong Wu
  • Publication number: 20160115202
    Abstract: Disclosed herein are bicyclic peptide compounds, compositions comprising same, methods for making same, and libraries comprising same. The disclosed compounds, in various aspects, are useful for treating a variety of disorders, including inflammatory disorders, autoimmune disorders, and disorders of uncontrolled cellular proliferation. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: May 23, 2014
    Publication date: April 28, 2016
    Inventors: Dehua Pei, Punit Upadhyaya, Wenlong Lian, Thi Trinh
  • Patent number: 9260484
    Abstract: A method of inhibiting a binding event between a target protein and a binding protein, comprising administering to a cell in vitro an effective amount of a non-naturally occurring bifunctional inhibitor molecule including (a) protein binding moiety, and (b) an effector region, wherein the protein binding moiety binds to a blocking protein, and wherein the effector region binds to the target protein in order to bind the target protein and the blocking protein and prevent access of the binding protein to the target protein. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: June 15, 2012
    Date of Patent: February 16, 2016
    Assignee: Ohio State Innovation Foundation
    Inventors: Roger Briesewitz, Dehua Pei, Xianghong Wu
  • Publication number: 20140200186
    Abstract: A method of inhibiting a binding event between a target protein and a binding protein, comprising administering to a cell in vitro an effective amount of a non-naturally occurring bifunctional inhibitor molecule including (a) protein binding moiety, and (b) an effector region, wherein the protein binding moiety binds to a blocking protein, and wherein the effector region binds to the target protein in order to bind the target protein and the blocking protein and prevent access of the binding protein to the target protein. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: June 15, 2012
    Publication date: July 17, 2014
    Inventors: Roger Briesewitz, Dehua Pei, Xianghong Wu
  • Publication number: 20090203631
    Abstract: A macrocyclic peptide deformylase (PDF) inhibitor comprising a peptide or peptide mimetic having three residues, P1?, P2?, and P3?, wherein P2? connects P1? and P3?, wherein P1? and P3? each have a side chain, and wherein the side chains on P1? and P3? are crosslinked to form the macrocyclic PDF inhibitor. The side chains of P1? and P3? interact with the PDF active site, and preferably, P2? has a side chain that interacts with a solvent. Also provided are methods of inhibiting the growth of a bacterium, the methods comprising contacting the bacterium with an anti-bacterial effective amount of the inventive macrocyclic PDF inhibitor. Additionally, a method of treating a bacterial infection in a subject comprising administering an effective amount of a macrocyclic PDF inhibitor to a subject in need of treatment.
    Type: Application
    Filed: April 15, 2009
    Publication date: August 13, 2009
    Applicant: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventor: Dehua Pei
  • Patent number: 7538085
    Abstract: A macrocyclic peptide deformylase (PDF) inhibitor comprising a peptide or peptide mimetic having three residues, P1?, P2?, and P3?, wherein P2? connects P1? and P3?, wherein P1? and P3? each have a side chain, and wherein the side chains on P1? and P3? are crosslinked to form the macrocyclic PDF inhibitor. The side chains of P1? and P3? interact with the PDF active site, and preferably, P2? has a side chain that interacts with a solvent. Also provided are methods of inhibiting the growth of a bacterium, the methods comprising contacting the bacterium with an anti-bacterial effective amount of the inventive macrocyclic PDF inhibitor. Additionally, a method of treating a bacterial infection in a subject comprising administering an effective amount of a macrocyclic PDF inhibitor to a subject in need of treatment.
    Type: Grant
    Filed: April 23, 2007
    Date of Patent: May 26, 2009
    Assignee: The Ohio State University Research Foundation
    Inventor: Dehua Pei
  • Publication number: 20070259812
    Abstract: A macrocyclic peptide deformylase (PDF) inhibitor comprising a peptide or peptide mimetic having three residues, P1?, P2?, and P3?, wherein P2? connects P1? and P3?, wherein P1? and P3? each have a side chain, and wherein the side chains on P1? and P3? are crosslinked to form the macrocyclic PDF inhibitor. The side chains of P1? and P3? interact with the PDF active site, and preferably, P2? has a side chain that interacts with a solvent. Also provided are methods of inhibiting the growth of a bacterium, the methods comprising contacting the bacterium with an anti-bacterial effective amount of the inventive macrocyclic PDF inhibitor. Additionally, a method of treating a bacterial infection in a subject comprising administering an effective amount of a macrocyclic PDF inhibitor to a subject in need of treatment.
    Type: Application
    Filed: April 23, 2007
    Publication date: November 8, 2007
    Inventor: Dehua Pei
  • Patent number: 7208595
    Abstract: A macrocyclic peptide deformylase (PDF) inhibitor comprising a peptide or peptide mimetic having three residues, P1?, P2?, and P3?, wherein P2? connects P1? and P3?, wherein P1? and P3? each have a side chain, and wherein the side chains on P1? and P3? are crosslinked to form the macrocyclic PDF inhibitor. The side chains of P1? and P3? interact with the PDF active site, and preferably, P2? has a side chain that interacts with a solvent. Also provided are methods of inhibiting the growth of a bacterium, the methods comprising contacting the bacterium with an anti-bacterial effective amount of the inventive macrocyclic PDF inhibitor. Additionally, a method of treating a bacterial infection in a subject comprising administering an effective amount of a macrocyclic PDF inhibitor to a subject in need of treatment.
    Type: Grant
    Filed: July 26, 2004
    Date of Patent: April 24, 2007
    Assignee: The Ohio State University Research Foundation
    Inventor: Dehua Pei
  • Publication number: 20050026821
    Abstract: A macrocyclic peptide deformylase (PDF) inhibitor comprising a peptide or peptide mimetic having three residues, P1?, P2?, and P3?, wherein P2? connects P1? and P3?,wherein P1? and P3? each have a side chain, and wherein the side chains on P1? and P3? are crosslinked to form the macrocyclic PDF inhibitor. The side chains of P1? and P3? interact with the PDF active site, and preferably, P2? has a side chain that interacts with a solvent. Also provided are methods of inhibiting the growth of a bacterium, the methods comprising contacting the bacterium with an anti-bacterial effective amount of the inventive macrocyclic PDF inhibitor. Additionally, a method of treating a bacterial infection in a subject comprising administering an effective amount of a macrocyclic PDF inhibitor to a subject in need of treatment.
    Type: Application
    Filed: July 26, 2004
    Publication date: February 3, 2005
    Inventor: Dehua Pei
  • Publication number: 20040009956
    Abstract: Methods of inhibiting protein tyrosine phosphatases (PTPs) and Src homology 2 domains (SH2) using neutral phosphotyrosine (pY) mimetics (PTP inhibitors) are provided. Neutral pY mimetics, or PTP inhibitors comprising an aldehyde or mono-ketone substituted aryl group are also provided. Substituents on the aryl groups of the PTP inhibitors provide further affinity for particular PTPs. PTP inhibitors comprising a reactive tripeptide substituent are also provided. Methods of using the neutral, reversible inhibitors as probes for studying the physiological functions of PTPs and SH2 domains are also provided. Methods of treating type II diabetes and obesity by administering a neutral pY mimetic that selectively and reversibly binds with PTP1B are also provided.
    Type: Application
    Filed: April 29, 2003
    Publication date: January 15, 2004
    Inventors: Dehua Pei, Junguk Park, Hua Fu