Patents by Inventor Deirdre Mary Bernadette Hickey

Deirdre Mary Bernadette Hickey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted Diketopiperazines As Oxytocin Antagonists
    Publication number: 20090186867
    Abstract: A method of treating or preventing diseases or conditions mediated through the action of oxytocin which comprises administering to a human in need thereof of an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: March 27, 2009
    Publication date: July 23, 2009
    Inventors: Alan David Borthwick, Richard Jonathan Hatley, Deirdre Mary Bernadette Hickey, John Liddle, David George Hubert Livermore, Andrew McMurtrie Mason, Neil Derek Miller, Fabrizio Nerozzi, Steven Leslie Sollis, Anna Katrin Szardenings, Paul Graham Wyatt
  • 5,6-Trimethylenepyrimidin-4-one compounds
    Publication number: 20090170877
    Abstract: Pyrimidone compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in treating atherosclerosis.
    Type: Application
    Filed: February 18, 2009
    Publication date: July 2, 2009
    Inventors: Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Stephen Allan Smith, Steven James Stanway
  • Piperazinediones as oxytocin receptor antagonists
    Patent number: 7550462
    Abstract: Compounds of formula (I) wherein R1 is 2-indanyl, R2 is 1-methylpropyl, R3 is a group selected from 2,6-dimethyl-3-pyridyl or 4,6-dimethyl-3-pyridyl, R4 represents methyl and R5 represents hydrogen or methyl or, R4 and R5 together with the nitrogen atom to which they are attached represent morpholino and pharmaceutically acceptable derivatives thereof are described, as are processes for their preparation, pharmaceutical compositions containing them and their use in medicine, particularly their use as oxytocin antagonists.
    Type: Grant
    Filed: June 21, 2005
    Date of Patent: June 23, 2009
    Assignee: Glaxo Group Limited
    Inventors: Alan David Borthwick, Deirdre Mary Bernadette Hickey, John Liddle, Andrew McMurtrie Mason
  • Novel Compounds
    Publication number: 20090118313
    Abstract: Pyrimidone compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in treating atherosclerosis.
    Type: Application
    Filed: January 6, 2009
    Publication date: May 7, 2009
    Inventors: Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Stephen Allan Smith, Steven James Stanway
  • Substituted diketopiperazines as oxytocin antagonists
    Patent number: 7514437
    Abstract: A method of treating or preventing diseases or conditions mediated through the action of oxytocin which comprises administering to a mammal in need thereof of an effective amount of a compound of the formula (I) and/or a physiologically acceptable derivative thereof, wherein the substituents have the meaning given in the description. Disclosed are also novel compounds of formula (I) and processes for their preparation.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: April 7, 2009
    Assignee: SmithKline Beecham Corp.
    Inventors: Alan David Borthwick, Richard Jonathan Hatley, Deirdre Mary Bernadette Hickey, John Liddle, David George Hubert Livermore, Andrew McMurtrie Mason, Neil Derek Miller, Fabrizio Nerozzi, Steven Leslie Sollis, Anna Katrin Szardenings, Paul Graham Wyatt
  • Pyrimidinone derivatives and their use in the treatment of atherosclerosis
    Patent number: 7462620
    Abstract: Compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in therapy, in particular for treating atherosclerosis.
    Type: Grant
    Filed: July 7, 2006
    Date of Patent: December 9, 2008
    Assignee: SmithKline Beecham, PLC
    Inventors: Deirdre Mary Bernadette Hickey, Colin Andrew Leach, Ivan Leo Pinto, Stephen Allan Smith
  • Lipoprotein associated phospholipase A2, inhibitors thereof and use of the same in diagnosis and therapy
    Patent number: 7314742
    Abstract: The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.
    Type: Grant
    Filed: April 18, 2005
    Date of Patent: January 1, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Colin Houston MacPhee, David Graham Tew, Christopher Donald Southan, Deirdre Mary Bernadette Hickey, Israel Simon Gloger, Geoffrey Mark Prouse Lawrence, Simon Quentyn John Rice
  • Pyridinone derivatives for treatment of atherosclerosis
    Patent number: 7235566
    Abstract: Compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in therapy, in particular for treating atherosclerosis.
    Type: Grant
    Filed: July 28, 2004
    Date of Patent: June 26, 2007
    Assignee: Smithkline Beecham p.l.c.
    Inventors: Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, John Liddle, Ivan Leo Pinto, Stephen Allan Smith, Steven James Stanway
  • Pyrimidinone derivatives and their use in the treatment of atherosclerosis
    Patent number: 7169924
    Abstract: Compound of formula (I): are disclosed in which: R1 is an aryl group, optionally substituted by 1, 2, 3 or 4 substituents which may be the same or different selected from C(1-6)alkyl, C(1-6)alkoxy, C(1-6)alkylthio, hydroxy, halogen, CN, and mono to perfluoro-C(1-4)alkyl; R2 is halogen, C(1-3)alkyl, C(1-3)alkoxy, hydroxyC(1-3)alkyl, C(1-3)alkylthio, C(1-3)alkylsulphinyl, aminoC(1-3)alkyl, mono- or di-C(1-3)alkylaminoC(1-3)alkyl, C(1-3)alkylcarbonylaminoC(1-3)alkyl, C(1-3)alkoxyC(1-3)alkylcarbonylaminoC(1-3)alkyl, C(1-3)alkylsulphonylaminoC(1-3)alkyl, C(1-3)alkylcarboxy, C(1-3)alkylcarboxyC(1-3)alkyl, and R3 is hydrogen, halogen, C(1-3)alkyl, or hydroxyC(1-3)alkcyl; or R2 and R3 together with the pyrimidone ring carbon atoms to which they are attached form a fused 5-or 6-membered carbocyclic ring; or R2 and R3 together with the pyrimidone ring carbon atoms to which they are attached form a fused benzo or heteroaryl ring ring optionally substituted by 1, 2, 3 or 4 substituents which may be the same or dif
    Type: Grant
    Filed: October 5, 2001
    Date of Patent: January 30, 2007
    Assignee: SmithKline Beecham plc
    Inventors: Richard Leonard Elliott, Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Stephen Allan Smith
  • Pyrimidinone compounds
    Patent number: 7115616
    Abstract: Pyrimidinone compounds of formula (10 are inhibitors of the enzyme Lp-PLA2 and of use in therapy, in particular for treating atherosclerosis.
    Type: Grant
    Filed: February 11, 2004
    Date of Patent: October 3, 2006
    Assignee: SmithKline Beecham Plc
    Inventors: Ashley Edward Fenwick, Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Stephen Allan Smith
  • Lipoprotein associated phospholipase A2, inhibitors thereof and use of the same in diagnosis and therapy
    Patent number: 7045329
    Abstract: The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.
    Type: Grant
    Filed: August 3, 2001
    Date of Patent: May 16, 2006
    Assignee: SmithKline Beecham plc
    Inventors: Colin Houston MacPhee, David Graham Tew, Christopher Donald Southan, Deirdre Mary Bernadette Hickey, Israel Simon Gloger, Geoffrey Mark Prouse Lawrence, Simon Quentyn John Rice
  • Pyrimidine compounds
    Patent number: 6953803
    Abstract: Pyrmidinone compounds of formula (I) are inhibitors of the enzyme Lp-PLA2 and of use in therapy, in particular for treating atherosclerosis.
    Type: Grant
    Filed: April 25, 2000
    Date of Patent: October 11, 2005
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Deirdre Mary Bernadette Hickey, Colin Andrew Leach, Stephen Allan Smith
  • Pyrimidinone compounds
    Publication number: 20040167142
    Abstract: Pyrimidinone compounds of formula (I) are inhibitors of the enzyme Lp-PLA2 and of use in therapy, in particular for treating atherosclerosis.
    Type: Application
    Filed: February 11, 2004
    Publication date: August 26, 2004
    Applicant: SmithKline Beecham p.l.c.
    Inventors: Ashley Edward Fenwick, Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Stephen Allan Smith
  • Novel Compounds
    Publication number: 20040097525
    Abstract: Pyrimidone compounds of formula (I): 1
    Type: Application
    Filed: October 27, 2003
    Publication date: May 20, 2004
    Applicant: SmithKline Beecham plc
    Inventors: Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Stephen Allan Smith, Steven James Stanway
  • Pyridinone derivatives for treatment of atherosclerosis
    Publication number: 20040063753
    Abstract: Compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in therapy, in particular for treating atherosclerosis.
    Type: Application
    Filed: September 9, 2003
    Publication date: April 1, 2004
    Inventors: Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, John Liddle, Ivan Leo Pinto, Stephen Allan Smith, Steven James Stanway
  • Pyrimidinone derivatives and their use in the treatment of atherosclerosis
    Publication number: 20040058941
    Abstract: Compounds of formula (I) are inhibitors of the enzyme Lp-PLA2 and are of use in therapy, in particular for treating athereosclerosis.
    Type: Application
    Filed: September 2, 2003
    Publication date: March 25, 2004
    Inventors: Richard Leonard Elliott, Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Stephen Allan Smith
  • Compounds
    Patent number: 6649619
    Abstract: Pyrimidone compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in treating atheroscelerosis.
    Type: Grant
    Filed: February 3, 2003
    Date of Patent: November 18, 2003
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Stephen Allan Smith, Steven James Stanway
  • Lipoprotein associated phospholipase A2, inhibitors thereof and use of the same in diagnosis and therapy
    Publication number: 20020177209
    Abstract: The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.
    Type: Application
    Filed: August 3, 2001
    Publication date: November 28, 2002
    Applicant: SmithKline Beecham plc
    Inventors: Colin Houston MacPhee, David Graham Tew, Christopher Donald Southan, Deirdre Mary Bernadette Hickey, Israel Simon Gloger, Geoffrey Mark Prouse Lawrence, Simon Quentyn John Rice
  • Pyrimidinone compounds and pharmaceutical compositions containing them
    Publication number: 20020120139
    Abstract: A group of novel pyrimidone compounds are inhibitors of the enzyme LDL PLA2 and therefore of use in treating atherosclerosis.
    Type: Application
    Filed: April 2, 2002
    Publication date: August 29, 2002
    Inventors: Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Roderick Alan Porter, Stephen Allan Smith
  • Novel compounds
    Publication number: 20020103213
    Abstract: Pyrimidone compounds of formula (I): 1
    Type: Application
    Filed: February 14, 2001
    Publication date: August 1, 2002
    Inventors: Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Stephen Allan Smith, Steven James Stanway