Abstract: A device for measuring finger dexterity, comprising a thumb portion configured to be releasably secured to a thumb, a finger portion configured to be releasably secured to an finger, wherein the finger portion and the thumb portion are connected by a flexible connector: a first rotatable element: a rotation sensor configured to sense rotation of the rotatable element, a microprocessor, wherein the microprocessor is in communication with the rotation sensor, and a transmitter configured for wireless communication with a computing device, wherein the rotatable element is configured to rotate when the finger portion and thumb portion move relative to each other, and wherein the microprocessor is configured to generate rotation data in response to rotation of the rotatable element, wherein the transmitter is configured to transmit the rotation data to the computing device.

Abstract: A method for screening a distressed neonate for risk of having or developing HIE comprises the steps of assaying a biological sample obtained from the distressed neonate, the mother of the neonate, or from the umbilical cord or placenta, for an abundance of miR-374a in the sample, and comparing the abundance of miR-374a in the sample with a reference abundance of miR-374a, wherein a reduced abundance of miR-374a in the sample compared with the reference abundance of miR-374a is indicative of the distressed neonate being at risk of having or developing HIE. Risk of severe HIE can be determined by assaying a biological sample from the distressed neonate identified as being at risk of HIE for an abundance of a plurality of metabolites including succinate, glycerol, acetone and 3-hydroxybutyrate, providing the sum of glycerol and succinate abundance and the sum of acetone and 3-hydroxybutyrate; and correlating the sums with risk of severe HIE.