Patents by Inventor Dejian Ren
Dejian Ren has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20170164591Abstract: Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper2) are disclosed. The CatSper2 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper2 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper2 activity, methods of genotyping subjects with respect to CatSper2, methods of diagnosing and treating CatSper2-mediated disorders, including infertility, as well as methods of doing business related to CatSper2-mediated disorders.Type: ApplicationFiled: February 28, 2017Publication date: June 15, 2017Inventors: Dejian REN, David CLAPHAM, David L. GARBERS, Timothy A. QUILL
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Publication number: 20170107269Abstract: Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper1) are disclosed. The CatSper1 protein is shown to be specifically expressed in sperm and to be necessary for sperm motility. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper1 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper1 activity, methods of genotyping subjects with respect to CatSper1, and methods of diagnosing and treating CatSper1-mediated disorders, including infertility.Type: ApplicationFiled: August 19, 2016Publication date: April 20, 2017Inventors: David CLAPHAM, Dejian REN
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Patent number: 9618521Abstract: Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper2) are disclosed. The CatSper2 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper2 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper2 activity, methods of genotyping subjects with respect to CatSper2, methods of diagnosing and treating CatSper2-mediated disorders, including infertility, as well as methods of doing business related to CatSper2-mediated disorders.Type: GrantFiled: April 10, 2014Date of Patent: April 11, 2017Assignees: Children's Medical Center Corporation, Board of Regents, The University of Texas SystemInventors: Dejian Ren, David Clapham, David L. Garbers, Timothy A. Quill
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Publication number: 20150219629Abstract: Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper1) are disclosed. The CatSper1 protein is shown to be specifically expressed in sperm and to be necessary for sperm motility. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper1 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper1 activity, methods of genotyping subjects with respect to CatSper1, and methods of diagnosing and treating CatSper1-mediated disorders, including infertility.Type: ApplicationFiled: September 2, 2014Publication date: August 6, 2015Applicant: CHILDREN'S MEDICAL CENTER CORPORATIONInventors: David CLAPHAM, Dejian REN
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Publication number: 20140363813Abstract: Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper2) are disclosed. The CatSper2 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper2 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper2 activity, methods of genotyping subjects with respect to CatSper2, methods of diagnosing and treating CatSper2-mediated disorders, including infertility, as well as methods of doing business related to CatSper2-mediated disorders.Type: ApplicationFiled: April 10, 2014Publication date: December 11, 2014Inventors: Dejian REN, David CLAPHAM, David L. GARBERS, Timothy A. QUILL
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Patent number: 8852860Abstract: Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper1) are disclosed. The CatSper1 protein is shown to be specifically expressed in sperm and to be necessary for sperm motility. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper1 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper1 activity, methods of genotyping subjects with respect to CatSper1, and methods of diagnosing and treating CatSper1-mediated disorders, including infertility.Type: GrantFiled: May 30, 2012Date of Patent: October 7, 2014Assignee: Children's Medical Center CorporationInventors: David Clapham, Dejian Ren
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Patent number: 8729248Abstract: Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper2) are disclosed. The CatSper2 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper2 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper2 activity, methods of genotyping subjects with respect to CatSper2, methods of diagnosing and treating CatSper2-mediated disorders, including infertility, as well as methods of doing business related to CatSper2-mediated disorders.Type: GrantFiled: January 29, 2008Date of Patent: May 20, 2014Assignees: Children's Medical Center Corporation, Board of Regents, The University of Texas SystemInventors: Dejian Ren, David Clapham, David L. Garbers, Timothy A. Quill
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Publication number: 20130102495Abstract: Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper1) are disclosed. The CatSper1 protein is shown to be specifically expressed in sperm and to be necessary for sperm motility. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper1 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper1 activity, methods of genotyping subjects with respect to CatSper1, and methods of diagnosing and treating CatSper1-mediated disorders, including infertility.Type: ApplicationFiled: May 30, 2012Publication date: April 25, 2013Applicant: CHILDREN'S MEDICAL CENTER CORPORATIONInventors: David E. CLAPHAM, Dejian REN
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Patent number: 8211666Abstract: Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper1) are disclosed. The CatSper1 protein is shown to be specifically expressed in sperm and to be necessary for sperm motility. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper1 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper1 activity, methods of genotyping subjects with respect to CatSper1, and methods of diagnosing and treating CatSper1-mediated disorders, including infertility.Type: GrantFiled: October 30, 2003Date of Patent: July 3, 2012Assignee: Children's Medical Center CorporationInventors: David E. Clapham, Dejian Ren
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Patent number: 7790845Abstract: The present invention relates to a functionally expressed bacterial voltage-sensitive ion-selective channel. The novel channel can be used in conjunction with mammalian ion channel pore-containing regions in assays for screening for compounds that modulate activity of the channel. One bacterial ion channel of the present invention, called NaChBac, is derived from Bacillus halodurans (GenBank#BAB05220 (8)).Type: GrantFiled: November 5, 2002Date of Patent: September 7, 2010Assignee: Children's Medical Center CorporationInventors: David Clapham, Dejian Ren
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Publication number: 20090104604Abstract: Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper2) are disclosed. The CatSper2 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper2 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper2 activity, methods of genotyping subjects with respect to CatSper2, methods of diagnosing and treating CatSper2-mediated disorders, including infertility, as well as methods of doing business related to CatSper2-mediated disorders.Type: ApplicationFiled: January 29, 2008Publication date: April 23, 2009Applicants: CHILDREN'S MEDICAL CENTER CORPORATION, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: Dejian REN, David CLAPHAM, David L. GARBERS, Timothy A. QUILL
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Publication number: 20050142566Abstract: Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper2) are disclosed. The CatSper2 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper2 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper2 activity, methods of genotyping subjects with respect to CatSper2, methods of diagnosing and treating CatSper2-mediated disorders, including infertility, as well as methods of doing business related to CatSper2-mediated disorders.Type: ApplicationFiled: April 21, 2004Publication date: June 30, 2005Applicants: Children's Medical Center Corporation, Board of Regents, The University of Texas SystemInventors: Dejian Ren, David Clapham, David Garbers, Timothy Quill
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Publication number: 20050101767Abstract: The present invention relates to a functionally expressed bacterial voltage-sensitive ion-selective channel. The novel channel can be used in conjunction with mammalian ion channel pore-containing regions in assays for screening for compounds that modulate activity of the channel. One bacterial ion channel of the present invention, called NaChBac, is derived from Bacillus halodurans (GenBank#BAB05220 (8)).Type: ApplicationFiled: November 5, 2002Publication date: May 12, 2005Inventors: David Clapham, Dejian Ren
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Publication number: 20040157292Abstract: Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper1) are disclosed. The CatSper1 protein is shown to be specifically expressed in sperm and to be necessary for sperm motility. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper1 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper1 activity, methods of genotyping subjects with respect to CatSper1, and methods of diagnosing and treating CatSper1-mediated disorders, including infertility.Type: ApplicationFiled: October 30, 2003Publication date: August 12, 2004Applicant: Children's Medical CenterInventors: David E. Clapham, Dejian Ren
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Patent number: 6207410Abstract: The present invention provides for the isolation and characterization of an invertebrate calcium channel subunit gene.Type: GrantFiled: July 16, 1997Date of Patent: March 27, 2001Assignee: The Research Foundation of State University of New YorkInventors: Linda M. Hall, Dejian Ren, Wei Zheng, Manuel Marcel Paul Dubald
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Patent number: 6027912Abstract: The present invention provides for the isolation and characterization of a calcium channel al subunit gene cloned from Drosophila melanogaster, and designated "DmcalD".Type: GrantFiled: January 19, 1995Date of Patent: February 22, 2000Assignee: The Research Foundation of State University of New YorkInventors: Linda M. Hall, Dejian Ren, Wei Zheng, Manuel Marcel Paul Dubald