Patents by Inventor Dejin FU

Dejin FU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for enzymatic preparation of fludarabine phosphate
    Patent number: 11421255
    Abstract: A method for enzymatic preparation of fludarabine phosphate, comprising reaction of fludarabine with a high-energy phosphate compound under the action of deoxyribonucleic acid kinase. According to said method, acetate kinase and acetyl phosphate free acid or acetyl phosphate are also added. The technical problems present in the existing processes are successfully addressed by employing the enzymatic process to prepare the fludarabine phosphate. The usage of the high-energy phosphate compound is reduced by means of adding acetate kinase to recycle and regenerate a small amount of the high-energy phosphate compound, thereby reducing the generation of by-products having similar structures to the fludarabine phosphate, enhancing the operation convenience of purification steps in the industrial production of the fludarabine phosphate. The process is environment friendly, the reaction conditions are moderate, the cost is low, and the yield and the purity of the product obtained are high.
    Type: Grant
    Filed: January 20, 2016
    Date of Patent: August 23, 2022
    Assignee: Zhejiang Hisun Pharmaceutical Co., Ltd.
    Inventors: Dejin Fu, Yong Yang, Wei Yan, Weijiang Wen, Xiande Gu, Hua Chen, Xiaojun Ma, Ling Zhang, Kaijun Wang
  • Crystal form of fludarabine phosphate, preparation method therefor, and application thereof
    Patent number: 10669302
    Abstract: Provided are a new crystal form of fludarabine phosphate, a preparation method therefor, a pharmaceutical composition containing same, and an application thereof in preparing medicine. Crystal forms I and II of the fludarabine phosphate have excellent properties in terms of solubleness, dissolution rate, chemical stability, and processing adaptability.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: June 2, 2020
    Assignee: ZHEJIANF HISUN PHARMACEUTICAL CO., LTD.
    Inventors: Zhiqing Yang, Liang Zhang, Xiangyang Zhang, Zhenjuan Shi, Di Su, Hongying Luo, Dejin Fu
  • CRYSTAL FORM OF FLUDARABINE PHOSPHATE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
    Publication number: 20190112327
    Abstract: Provided are a new crystal form of fludarabine phosphate, a preparation method therefor, a pharmaceutical composition containing same, and an application thereof in preparing medicine. Crystal forms I and II of the fludarabine phosphate have excellent properties in terms of solubleness, dissolution rate, chemical stability, and processing adaptability.
    Type: Application
    Filed: August 26, 2016
    Publication date: April 18, 2019
    Inventors: Zhiqing YANG, Liang ZHANG, Xiangyang ZHANG, Zhenjuan SHI, Di SU, Hongying LUO, Dejin FU
  • CRYSTAL FORM OF FLUDARABINE PHOSPHATE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
    Publication number: 20180244711
    Abstract: Provided are a new crystal form of fludarabine phosphate, a preparation method therefor, a pharmaceutical composition containing same, and an application thereof in preparing medicine. Crystal forms I and II of the fludarabine phosphate have excellent properties in terms of solubleness, dissolution rate, chemical stability, and processing adaptability.
    Type: Application
    Filed: August 26, 2016
    Publication date: August 30, 2018
    Inventors: Zhiqing YANG, Liang ZHANG, Xiangyang ZHANG, Zhenjuan SHI, Di SU, Hongying LUO, Dejin FU