Abstract: The present invention relates to the field of rock mechanics technology, and provides a three-dimensional water absorption swelling multifunctional experimental machine and method for chemical swelling rock, comprising a triaxial high-temperature and high-pressure reaction chamber, the triaxial high-temperature and high-pressure reaction chamber is respectively connected with a confining pressure loading controller, a water pressure loading controller, a temperature controller, an axial pressure loading controller, a pH value monitor and a data acquisition and analyzer; the triaxial high-temperature and high-pressure reaction chamber includes a set of internal cavity and an external cavity, a sealing liner sleeve is provided between the internal cavity and the external cavity, a rock sample is provided in the internal cavity, a water-permeable pressure hoop is provided outside the rock sample, and the sealing liner sleeve is connected with a circumferential stress-strain sensor through a displacement structur

Abstract: A compound with broad-spectrum antibacterial activity and its antibacterial composition are provided. The compound with broad-spectrum antibacterial activity has formula (I), which are antibacterial drug source compounds with a broad antibacterial spectrum, good antibacterial activity, suitable in vivo pharmacokinetics, and significant in vivo therapeutic effects. Preferred compound BAB159 has good antibacterial activity against Staphylococcus, Clostridium perfringens, Enterococcus, Bacillus, Streptococcus, Haemophilus, Candida krusei, Aspergillus niger, and Trichophyton, which is comparable or better than the listed drugs. The combination of preferred compound BAB159 and polymyxin E exhibits significantly enhanced synergistic antibacterial activity, especially against multidrug-resistant strains.

Abstract: This disclosure provides a lock having a rotating component, the rotation of which drives the retractable movement of a latch bolt, and the rotating component is equipped with a trigger component; a first sensing component, fixedly set or arranged at the first position of the lock, where the first position is the position indicated by a knob fixedly connected to the rotating component when the lock is in the unlocked state, and when the trigger component is at the first position, the first sensing component generates a first trigger signal; a second sensing component is fixedly set or arranged at the second position of the lock, where the second position is the position indicated by the knob when the lock is in the locked state, and when the trigger component is at the second position, the second sensing component generates a second trigger signal.

Abstract: A charging compartment system and relates to a technical field of charging device, the charging compartment system includes a charging module for charging a low-power battery; a driving module for moving a battery out of or into the charging compartment; a controller electrically connected with both the charging module and the driving module. The charging compartment system further includes a detection module for detecting whether a fully charged battery is picked by a user after being moved out of the charging compartment for a period of time, if the fully charged battery is not picked, the driving module moves the fully charged battery into the charging compartment, and if the fully charged battery is picked, the controller prompts that the charging compartment is an empty charging compartment. The disclosure has technical effect that the charged battery can be ejected, and users can save time and labor when picking the battery.

Abstract: A charging cabinet system includes a power supply system, a controlling and displaying system, and a plurality of charging compartments. The power supply system is connected with the controlling and displaying system. The charging compartment is connected with both the power supply system and the controlling and displaying system. The charging compartment includes: a charging module for charging a low-power battery; a driving module for moving the battery out of the charging compartment or moving the battery into the charging compartment; a detection module for detecting whether a fully charged battery is picked by a user after being moved out of the charging compartment for a period of time; and a controller connected with the charging module, the driving module and the detection module, and connected with the controlling and displaying system. The technical effect of the disclosure is that it can effectively prevent the battery from being lost.

Abstract: The present disclosure provides methods of preparing cholic acid, deoxycholic acid, or chenodeoxycholic acid, an ester thereof, or a pharmaceutically or cosmetically acceptable salt thereof, and novel and useful synthetic intermediates, for example, as described for methods 1, 1A, 1B, 2, 3, 3A, and 4. The method can start with a plant derived steroid as a starting material, such as dehydroepiandrosterone (DHEA) or Acetyl-dehydroepiandrosterone (Ac-DHEA). Also provided are pharmaceutical or cosmetic compositions and uses thereof, which comprise one or more of cholic acid, deoxycholic acid, or chenodeoxycholic acid, an ester thereof, or a pharmaceutically or cosmetically acceptable salt thereof, which is of high purity, for example, free of animal derived impurities.

Abstract: The present disclosure provides methods of preparing cholic acid, deoxycholic acid, or chenodeoxycholic acid, an ester thereof, or a pharmaceutically or cosmetically acceptable salt thereof, and novel and useful synthetic intermediates, for example, as described for methods 1, 1A, 1B, 2, 3, 3A, and 4. The method can start with a plant derived steroid as a starting material, such as dehydroepiandrosterone (DHEA) or Acetyl-dehydroepiandrosterone (Ac-DHEA). Also provided are pharmaceutical or cosmetic compositions and uses thereof, which comprise one or more of cholic acid, deoxycholic acid, or chenodeoxycholic acid, an ester thereof, or a pharmaceutically or cosmetically acceptable salt thereof, which is of high purity, for example, free of animal derived impurities.

Abstract: The present disclosure provides methods of preparing cholic acid, deoxycholic acid, or chenodeoxycholic acid, an ester thereof, or a pharmaceutically or cosmetically acceptable salt thereof, and novel and useful synthetic intermediates, for example, as described for methods 1, 1A, 1B, 2, 3, 3A, and 4. The method can start with a plant derived steroid as a starting material, such as dehydroepiandrosterone (DHEA) or Acetyl-dehydroepiandrosterone (Ac-DHEA). Also provided are pharmaceutical or cosmetic compositions and uses thereof, which comprise one or more of cholic acid, deoxycholic acid, or chenodeoxycholic acid, an ester thereof, or a pharmaceutically or cosmetically acceptable salt thereof, which is of high purity, for example, free of animal derived impurities.

Abstract: The present invention is directed to novel phenylpyridone derivative compounds. The compounds act as a melanin concentrating hormone receptor antagonists, and can be useful in preventing, treating or acting as a remedial agent for various circular system diseases, nervous system diseases, metabolic diseases, genital diseases, respiratory diseases and digestive diseases.