Patents by Inventor Deli ZHUGE

Deli ZHUGE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation method and application of biomimetic nano-protectant for detoxifying dox-induced cardiac and systemic toxicity
    Patent number: 12102690
    Abstract: A preparation method and application of a biomimetic nano-protectant for detoxifying doxorubicin (DOX)-induced cardiac and systemic toxicity are provided. The preparation method comprises the following steps: obtaining and mixing DNA and protamine (Pro) to prepare DNA&Pro nanoparticles; reacting heterofunctional polyethylene glycol DSPE-PEG2000-MAL with PCM/KALA to prepare DSPE-PEG2000-PCM/KALA; inserting DSPE-PEG2000-PCM/KALA into a surface of Red Blood Cell Membrane (RBCM) to prepare PCM/KALA-RBCM; and mixing the RBCM-PCM/KALA with the DNA&Pro nanoparticles to prepare a biomimetic nano-protectant DNA&Pro@RBCM-PCM/KALA. The biomimetic nano-protectant prepared is applied to detoxification of DOX.
    Type: Grant
    Filed: June 27, 2022
    Date of Patent: October 1, 2024
    Assignee: THE SECOND AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIVERSITY
    Inventors: Yijie Chen, Mengchun Chen, Weiliang Xia, Deli Zhuge, Haiyan Zhu, Yingzheng Zhao, Qi Jiang
  • PREPARATION METHOD AND APPLICATION OF BIOMIMETIC NANO-PROTECTANT FOR DETOXIFYING DOX-INDUCED CARDIAC AND SYSTEMIC TOXICITY
    Publication number: 20240207436
    Abstract: A preparation method and application of a biomimetic nano-protectant for detoxifying doxorubicin (DOX)-induced cardiac and systemic toxicity are provided. The preparation method comprises the following steps: obtaining and mixing DNA and protamine (Pro) to prepare DNA&Pro nanoparticles; reacting heterofunctional polyethylene glycol DSPE-PEG2000-MAL with PCM/KALA to prepare DSPE-PEG2000-PCM/KALA; inserting DSPE-PEG2000-PCM/KALA into a surface of Red Blood Cell Membrane (RBCM) to prepare PCM/KALA-RBCM; and mixing the RBCM-PCM/KALA with the DNA&Pro nanoparticles to prepare a biomimetic nano-protectant DNA&Pro@RBCM-PCM/KALA. The biomimetic nano-protectant prepared is applied to detoxification of DOX.
    Type: Application
    Filed: June 27, 2022
    Publication date: June 27, 2024
    Applicant: The Second Affiliated Hospital of Wenzhou Medical University
    Inventors: Yijie CHEN, Mengchun CHEN, Weiliang XIA, Deli ZHUGE, Haiyan ZHU, Yingzheng ZHAO, Qi JIANG