Patents by Inventor Deling Shi

Deling Shi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for identifying whether porcine heparin is adulterated with heparin from ruminants
    Patent number: 11624736
    Abstract: The present application is related to a method for identifying whether porcine heparin is adulterated with heparin from ruminants, comprising: (1) respectively detecting the contents of trisaccharide(4S) and ?UA2S-GlcNAc6S (?IA) in a sample and at least three batches of porcine heparin standards; (2) calculating a ratio of the trisaccharide(4S) to the ?IA as well as a standard deviation (SD) of the ratio in the porcine heparin standards; when the ratio of the trisaccharide(4S) to the ?IA in the sample exceeds a maximum value of the ratio in the porcine heparin standards+3SD, where the sample is considered to be mixed or adulterated with heparin from ruminants; wherein the detection method used is hydrophilic interaction liquid chromatography-mass spectrometry (HILIC-MS) or multiple reaction monitoring (MRM). The method can distinguish porcine heparin from ovine and bovine heparin based on the structural differences, regardless of the production process the heparin has undergone.
    Type: Grant
    Filed: September 7, 2022
    Date of Patent: April 11, 2023
    Assignees: Shandong University, Shandong Institute for Food and Drug Control
    Inventors: Lianli Chi, Deling Shi, Bin Zhang, Feng Shi, Mengmeng Li, Baojian Hang
  • SEQUENCING METHOD, SYSTEM AND KIT OF LOW MOLECULAR WEIGHT HEPARIN OLIGOSACCHARIDES
    Publication number: 20220404379
    Abstract: A sequencing method, system and kit of low molecular weight heparin (LMWH) oligosaccharides are provided.
    Type: Application
    Filed: January 17, 2022
    Publication date: December 22, 2022
    Applicants: Shandong University, National Institute of Metrology, China
    Inventors: Lianli Chi, Deling Shi, Bing Zhang, Tianji Zhang, Fei Li, Qingqing Chen