Patents by Inventor Delphine Bregeon

Delphine Bregeon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enzymatic conjugation of antibodies
    Patent number: 10675359
    Abstract: The present application relates to methods for the functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.
    Type: Grant
    Filed: September 12, 2017
    Date of Patent: June 9, 2020
    Assignees: Innate Pharma, Paul Scherrer Institut
    Inventors: Patrick Dennler, Delphine Bregeon, Laurent Gauthier, François Romagné, Christian Belmant, Eliane Fischer, Roger Schibli
  • Solid phase TGase-mediated conjugation of antibodies
    Patent number: 10611824
    Abstract: Some embodiments described herein relate to solid-support based processes for the functionalization of immunoglobulins through the use of transglutaminase. Also provided are solid support compositions with bound antibody. The methods can be used, for example, in manufacturing processes or in drug screening.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: April 7, 2020
    Assignee: Innate Pharma
    Inventor: Delphine Bregeon
  • IMMUNOMODULATORY ANTIBODY DRUG CONJUGATES BINDING TO A HUMAN MICA POLYPEPTIDE
    Publication number: 20200023071
    Abstract: The present invention provides antigen-binding proteins capable of binding to human MICA polypeptides, conjugated to cytotoxic agents. Said conjugates have increased activity in the treatment of disorders characterized by MICA-expressing cells, particularly tumor cells.
    Type: Application
    Filed: February 5, 2018
    Publication date: January 23, 2020
    Inventors: MATHIEU BLERY, DELPHINE BREGEON, LAURENT GAUTHIER, FLORENCE LHOSPICE, LAURENT POUYET
  • Enzymatic conjugation of polypeptides
    Patent number: 10434180
    Abstract: The present application relates to methods for the enzymatic functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.
    Type: Grant
    Filed: July 19, 2016
    Date of Patent: October 8, 2019
    Assignees: INNATE PHARMA, PAUL SCHERRER INSTITUT
    Inventors: Delphine Bregeon, Patrick Dennler, Christian Belmant, Laurent Gauthier, François Romagne, Eliane Fischer, Roger Schibli
  • Screening of conjugated antibodies
    Patent number: 10132799
    Abstract: Provided is a method for the functionalization of immunoglobulins through the use of transglutaminase, including methods for screening functionalized antibodies for characteristics of interest, antibody compositions comprising a plurality of functionalized antibodies, and functionalized antibodies with rodent constant regions.
    Type: Grant
    Filed: July 10, 2013
    Date of Patent: November 20, 2018
    Assignees: INNATE PHARMA, PAUL SCHERRER INSTITUT
    Inventors: Christian Belmant, Delphine Bregeon, Patrick Dennler, Eliane Fischer, François Romagne, Roger Schibli, Laurent Gauthier
  • Enzymatic conjugation of polypeptides
    Patent number: 10071169
    Abstract: One embodiment relates to methods for the enzymatic functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.
    Type: Grant
    Filed: June 20, 2014
    Date of Patent: September 11, 2018
    Assignee: INNATE PHARMA
    Inventor: Delphine Bregeon
  • ENZYMATIC CONJUGATION OF ANTIBODIES
    Publication number: 20180193476
    Abstract: The present application relates to methods for the functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.
    Type: Application
    Filed: September 12, 2017
    Publication date: July 12, 2018
    Inventors: Patrick Dennler, Delphine Bregeon, Laurent Gauthier, François Romagné, Christian Belmant, Eliane Fischer, Roger Schibli
  • ENZYMATIC CONJUGATION OF POLYPEPTIDES
    Publication number: 20180071402
    Abstract: The present application relates to methods for the functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.
    Type: Application
    Filed: July 19, 2017
    Publication date: March 15, 2018
    Inventors: Delphine Bregeon, Patrick Dennler, Christian Belmant, Eliane Fischer, Laurent Gauthier, Francois Romagné, Roger Schibli
  • Enzymatic conjugation of antibodies
    Patent number: 9764038
    Abstract: The present application relates to methods for the functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: September 19, 2017
    Assignees: INNATE PHARMA, PAUL SCHERRER INSTITUT
    Inventors: Patrick Dennler, Delphine Bregeon, Laurent Gauthier, François Romagné, Christian Belmant, Eliane Fischer, Roger Schibli
  • Enzymatic conjugation of polypeptides
    Patent number: 9717803
    Abstract: The present application relates to methods for the functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: August 1, 2017
    Assignees: INNATE PHARMA, PAUL SCHERRER INSTITUT
    Inventors: Delphine Bregeon, Patrick Dennler, Christian Belmant, Eliane Fischer, Laurent Gauthier, Francois Romagné, Roger Schibli
  • ENZYMATIC CONJUGATION OF POLYPEPTIDES
    Publication number: 20160331842
    Abstract: The present application relates to methods for the enzymatic functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.
    Type: Application
    Filed: July 19, 2016
    Publication date: November 17, 2016
    Inventors: Delphine Bregeon, Patrick Dennler, Christian Belmant, Laurent Gauthier, François Romagne, Eliane Fischer, Roger Schibli
  • Enzymatic conjugation of polypeptides
    Patent number: 9427478
    Abstract: The present application relates to methods for the enzymatic functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.
    Type: Grant
    Filed: December 23, 2014
    Date of Patent: August 30, 2016
    Assignees: Innate Pharma, Paul Scherrer Institut
    Inventors: Delphine Bregeon, Patrick Dennler, Christian Belmant, Laurent Gauthier, François Romagne, Eliane Fischer, Roger Schibli
  • ENZYMATIC CONJUGATION OF POLYPEPTIDES
    Publication number: 20160114056
    Abstract: One embodiment relates to methods for the enzymatic functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.
    Type: Application
    Filed: June 20, 2014
    Publication date: April 28, 2016
    Inventor: Delphine Bregeon
  • SOLID PHASE TGASE-MEDIATED CONJUGATION OF ANTIBODIES
    Publication number: 20160022833
    Abstract: Some embodiments described herein relate to solid-support based processess for the functionalization of immunoglobulins through the use of transglutaminase. Also provided are solid support compositions with bound antibody. The methods can be used, for example, in manufacturing processes or in drug screening.
    Type: Application
    Filed: March 14, 2014
    Publication date: January 28, 2016
    Inventor: Delphine Bregeon
  • SCREENING OF CONJUGATED ANTIBODIES
    Publication number: 20150346195
    Abstract: Provided is a method for the functionalization of immunoglobulins through the use of transglutaminase, including methods for screening functionalized antibodies for characteristics of interest, antibody compositions comprising a plurality of functionalized antibodies, and functionalized antibodies with rodent constant regions.
    Type: Application
    Filed: July 10, 2013
    Publication date: December 3, 2015
    Inventors: Christian Belmant, Delphine Bregeon, Patrick Dennler, Eliane Fischer, François Romagne, Roger Schibli
  • ENZYMATIC CONJUGATION OF POLYPEPTIDES
    Publication number: 20150165064
    Abstract: The present application relates to methods for the enzymatic functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.
    Type: Application
    Filed: December 23, 2014
    Publication date: June 18, 2015
    Inventors: Delphine Bregeon, Patrick Dennler, Christian Belmant, Laurent Gauthier, François Romagne, Eliane Fischer, Roger Schibli
  • ENZYMATIC CONJUGATION OF ANTIBODIES
    Publication number: 20140356385
    Abstract: The present application relates to methods for the functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.
    Type: Application
    Filed: December 21, 2012
    Publication date: December 4, 2014
    Inventors: Patrick Dennler, Delphine Bregeon, Laurent Gauthier, François Romagné, Christian Belmant, Eliane Fischer, Roger Schibli
  • TLR3 Agonist Compositions
    Publication number: 20110076296
    Abstract: The present invention relates generally to the fields of medicine. More specifically, the present invention relates to improved TLR3 agonists. The present invention provides novel dsRNA such as polyAU composition useful in the treatment of TLR3 related diseases, uses and preparations thereof.
    Type: Application
    Filed: April 22, 2009
    Publication date: March 31, 2011
    Applicant: INNATE PHARMA S.A.
    Inventors: Eric Aubin, Christian Belmant, Laurent Gauthier, Yannis Morel, Carine Paturel, Delphine Bregeon