Abstract: This invention is directed to compositions including IRAK4 inhibitors useful for the treatment of dermatological disorders or conditions characterized by inflammation. This invention is also directed to methods for treating the dermatological disorders or conditions.

Abstract: The present disclosure is directed to use of ROR?t inhibitors in the treatment of autoimmune disorders, e.g., autoimmune disorders of the skin. This invention is also directed to pharmaceutical compositions comprising an ROR?t inhibitor and a pharmaceutically acceptable carrier for topical administration.

Abstract: Applicators for topical administration of anticholinergic compounds to a subject in need thereof include, in embodiments, a roll-on applicator, and a bottle that attaches to the roll-on applicator. Also disclosed herein are methods of treating conditions in a subject in need thereof by administering therapeutically effective anticholinergic compounds to the skin of the subject with an applicator disclosed herein.

Abstract: A system for transdermal delivery of risperidone to an individual. The system has a high risperidone loading with suitable permeation enhancers to effect therapeutic flux rate. Acrylate polymeric reservoir with the high risperidone and permeation enhancers dissolved therein provides desirable adhesive characteristics and effective transdermal therapeutic properties.

Abstract: A transdermal galantamine delivery system to an individual. The system has a high galantamine loading with suitable permeation enhancers to effect therapeutic flux rate. Acrylate polymeric reservoir with the high galantamine and permeation enhancers dissolved therein provides desirable adhesive characteristics and effective transdermal therapeutic properties for multiple-day delivery.

Abstract: A system for transdermal delivery of norelgestromin (NGMN) to an individual. The system has a high NGMN loading with suitable permeation enhancers to effect therapeutic flux rate. Polyacrylate drug reservoir with the NGMN and high loading of one or more of permeation enhancers and NGMN dissolved therein provides desirable adhesive characteristics and effective transdermal therapeutic properties. Estrogen can be delivered with the NGMN.

Abstract: A flexible test device and a method for irritation testing of formulations on skin. The test device includes a flexible substrate, a group of formulations secured on the flexible patch for application on the skin of an animal such that the test device conforms to the skin for the formulations to contact the skin, and adhesive for attaching the test device to the skin for a predetermined period of time.

Abstract: A new design for a static diffusion cell for use in a diffusion sampling apparatus to be used in conjunction with automated or manual sampling is disclosed. The diffusion cell of present invention provides to an improved and efficient diffusion assay system.