Patents by Inventor Delwood C. Collins

Delwood C. Collins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phosphonated agents and their antiangiogenic and antitumorigenic use
    Patent number: 6160166
    Abstract: Phosphonic acid agents are synthesized and characterized which are potent inhibitors of angiogenesis, tumorigenesis and metalloproteinase activity. Their method of use for the inhibition of angiogenesis and metalloproteinase and the treatment of tumors is also shown.
    Type: Grant
    Filed: July 21, 1999
    Date of Patent: December 12, 2000
    Assignee: The University of Kentucky Research Foundation
    Inventors: Delwood C. Collins, Antonio R. Gagliardi, Peter Nickel
  • Phosphonated agents and their antiangiogenic and antitumorigenic use
    Patent number: 6096730
    Abstract: Phosphonic acid agents are synthesized and characterized which are potent inhibitors of angiogenesis, tumorigenesis and metalloproteinase activity. Their method of use for the inhibition of angiogenesis and metalloproteinase and the treatment of tumors is also shown.
    Type: Grant
    Filed: July 23, 1998
    Date of Patent: August 1, 2000
    Assignee: University of Kentucky Research Foundation
    Inventors: Delwood C. Collins, Antonio R. Gagliardi, Peter Nickel
  • Method for treating infection using steroid based pharmaceutical compositions
    Patent number: 5733899
    Abstract: A method of treating a bacterial or fungal infection in a patient by administering an effective amount of a compound of Formula (III): ##STR1## wherein, the substituents are as defined in the specification.
    Type: Grant
    Filed: April 20, 1995
    Date of Patent: March 31, 1998
    Assignee: Magainin Pharmaceuticals Inc.
    Inventors: Leah L. Frye, Michael A. Zasloff, William A. Kinney, Robert Moriarty, Delwood C. Collins
  • Method for inhibiting angiogenesis using squalamine and squalamine steroid derivatives
    Patent number: 5721226
    Abstract: A method of inhibiting angiogenesis in a patient includes administering to the patient an effective amount of squalamine or a pharmaceutically acceptable salt of squalamine. Alternatively, a compound according to the following Formula (III) (or a pharmaceutically acceptable salt thereof) can be administered: ##STR1## wherein Z.sub.5 is .alpha.-H or .beta.-H; each of the substituents Z.sub.7 is selected from the group of --H, --OH, --SH, --NH.sub.2, --F, --(C.sub.1 -C.sub.3)-alkyl, and --(C.sub.1 -C.sub.3)-alkoxy; and one of the substituents Z.sub.12 is --H and the other is --H or --OH. X' is a polyamine side chain of the formula --X.sub.1 --(CH.sub.2).sub.p --X.sub.2 --(CH.sub.2).sub.q --N(R.sup.II)(R.sup.III), wherein one of X.sub.1 and X.sub.2 is --N(R.sup.IV) and the other is selected from the group of --N(R.sup.V), --O, --S, and --CH.sub.2. R.sup.IV and R.sup.V are each --H or --(C.sub.1 -C.sub.3)-alkyl, p and q are each an integer of from 0 to 5 (but both are not 0). R.sup.II and R.sup.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 24, 1998
    Assignee: Magainin Pharmaceuticals Inc.
    Inventors: Leah L. Frye, Michael A. Zasloff, William A. Kinney, Robert Moriarty, Delwood C. Collins
  • Method for inhibiting angiogenesis with aurintricarboxylic acid, its analogues or salts
    Patent number: 5434185
    Abstract: Aurintricarboxylic acid has potent anti-angiogenic activity and may be used for new therapeutic approaches for diseases of neovascularization including the treatment of solid tumors, diabetic retinopathy and arthritis, among others.
    Type: Grant
    Filed: May 17, 1993
    Date of Patent: July 18, 1995
    Assignee: The University of Kentucky Research Foundation
    Inventors: Delwood C. Collins, Antonio Gagliardi, Anjan Bhattacharyya