Patents by Inventor Demetrios Braddock

Demetrios Braddock has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENPP1 POLYPEPTIDES AND METHODS OF USING SAME
    Publication number: 20250230423
    Abstract: The present disclosure includes ENPP1 mutant polypeptides with improved in vivo half-lives.
    Type: Application
    Filed: August 26, 2024
    Publication date: July 17, 2025
    Inventors: Paul Stabach, Demetrios Braddock
  • ENPP1 polypeptides and methods of using same
    Patent number: 12344868
    Abstract: The present invention includes ENPP1 polypeptides with improved in vivo half-lives. The invention further provides an ENPP1 polypeptide fusion comprising an ENPP1 polypeptide fused to a Fc region of an immunoglobulin, wherein the polypeptide fusion comprises at least one point mutation.
    Type: Grant
    Filed: August 31, 2019
    Date of Patent: July 1, 2025
    Assignee: YALE UNIVERSITY
    Inventors: Paul Stabach, Demetrios Braddock
  • Compositions for treating ectopic calcification disorders, and methods using same
    Patent number: 12234489
    Abstract: The present invention includes compositions and methods for treating disease and disorders associated with pathological calcification or pathological ossification.
    Type: Grant
    Filed: December 19, 2022
    Date of Patent: February 25, 2025
    Assignee: YALE UNIVERSITY
    Inventors: Demetrios Braddock, Enrique De La Cruz
  • Compositions and methods for reducing progression of nephrolithiasis
    Patent number: 12157903
    Abstract: The present invention includes compositions and methods for treating and/or preventing renal and/or kidney stones in a human subject. In certain embodiments, the subject is administered certain ENPP1 polypeptides or ENPP3 polypeptides, mutants, or mutant fragments thereof.
    Type: Grant
    Filed: May 7, 2019
    Date of Patent: December 3, 2024
    Assignee: YALE UNIVERSITY
    Inventors: Demetrios Braddock, Clemens Bergwitz
  • Compositions for treating pathological calcification conditions, and methods using same
    Patent number: 12128087
    Abstract: The present invention includes compositions and methods for treating diseases or disorders associated with pathological calcification or pathological ossification. In certain embodiments, the diseases or disorders are selected from the group consisting of Generalized Arterial Calcification of Infancy (GACI), Idiopathic Infantile Arterial Calcification (IIAC), Ossification of the Posterior Longitudinal Ligament (OPLL), hypophosphatemic rickets, osteoarthritis, calcification of atherosclerotic plaques, PXE, hereditary and non-hereditary forms of osteoarthritis, ankylosing spondylitis, hardening of the arteries occurring with aging, calciphylaxis resulting from end stage renal disease and progeria.
    Type: Grant
    Filed: July 7, 2021
    Date of Patent: October 29, 2024
    Assignee: YALE UNIVERSITY
    Inventors: Demetrios Braddock, Ronald Albright
  • LIVER SPECIFIC PRODUCTION OF ENPP1 OR ENPP3
    Publication number: 20240148907
    Abstract: The present disclosure provides, among other things, vectors for expression of ENPP1 or ENPP3 in vivo and methods for the treatment of diseases of calcification and ossification in a subject.
    Type: Application
    Filed: April 7, 2023
    Publication date: May 9, 2024
    Inventors: Steven Jungles, Demetrios Braddock
  • COMPOSITIONS AND METHODS FOR TREATING, AMELIORATING, AND/OR PREVENTING DISEASES OR DISORDERS CAUSED BY OR ASSOCIATED WITH DNASE1 AND/OR DNASE1L3 DEFICIENCY
    Publication number: 20230416358
    Abstract: The present disclosure includes novel DNAse1 and/or DNAse1L3 constructs with improved in vivo half-lives, enzymatic stability, and/or developability properties.
    Type: Application
    Filed: July 18, 2023
    Publication date: December 28, 2023
    Inventors: Paul Stabach, Demetrios Braddock
  • SOLUBLE ENPP1 PROTEINS AND USES THEREOF
    Publication number: 20230313158
    Abstract: In certain aspects, the present invention provides novel soluble ENPP1 or ENPP3 polypeptides, as well as compositions and methods for using those variants to treat an indication associated an ENPP1 or ENPP3 deficiency. The compositions and methods provided herein are useful in treating diseases associated with an ENPP1 or ENPP3 deficiency such as pathological calcification or pathological ossification.
    Type: Application
    Filed: December 8, 2022
    Publication date: October 5, 2023
    Inventors: Zhiliang Cheng, Demetrios Braddock, Paul Stabach, Steven Jungles
  • COMPOSITIONS AND METHODS FOR TREATING AND/OR PREVENTING COAGULOPATHY AND/OR SEPSIS IN PATIENTS SUFFERING FROM BACTERIAL AND/OR VIRAL INFECTIONS
    Publication number: 20230226158
    Abstract: The present disclosure includes compositions and methods for treating, ameliorating, and/or preventing immune mediated pathology associated with a bacterial and/or viral infection.
    Type: Application
    Filed: June 8, 2021
    Publication date: July 20, 2023
    Inventors: Paul Stabach, Demetrios Braddock
  • COMPOSITIONS FOR TREATING ECTOPIC CALCIFICATION DISORDERS, AND METHODS USING SAME
    Publication number: 20230227800
    Abstract: The present invention includes compositions and methods for treating disease and disorders associated with pathological calcification or pathological ossification.
    Type: Application
    Filed: December 19, 2022
    Publication date: July 20, 2023
    Inventors: Demetrios Braddock, Enrique DE LA CRUZ
  • CXCR5 Antagonists and Methods of Treating Diseases or Disorders Using Same
    Publication number: 20230146903
    Abstract: The disclosure provides compounds, and compositions comprising such compounds, that can be used to treat CXCR5-expressing cancers, especially angioimmunoblastic T cell lymphoma (AICL) and/or cutaneous T cell lymphoma (CTCL).
    Type: Application
    Filed: March 30, 2021
    Publication date: May 11, 2023
    Inventors: Elias Lolis, Francine Foss, Demetrios Braddock, Yulia Surovtseva, Christopher Fanger, Mark Plummer, Denton Hoyer, Elizabeth Spencer
  • COMPOSITIONS AND METHODS FOR TREATING, AMELIORATING, AND/OR PREVENTING DISEASES OR DISORDERS CAUSED BY OR ASSOCIATED WITH DNASE1 AND/OR DNASE1L3 DEFICIENCY
    Publication number: 20230062096
    Abstract: The present disclosure includes novel DNAse1 and/or DNAse1L3 constructs with improved in vivo half-lives, enzymatic stability, and/or developability properties.
    Type: Application
    Filed: January 11, 2021
    Publication date: March 2, 2023
    Inventors: Paul Stabach, Demetrios Braddock
  • COMPOSITIONS AND METHODS FOR STROKE PREVENTION IN PEDIATRIC SICKLE CELL ANEMIA PATIENTS
    Publication number: 20230038046
    Abstract: The present invention includes compositions and methods for treating stroke in sickle cell anemia (SCA) patients. In certain embodiments, the patient is administered certain ENPP1- or ENNP3-containing polypeptides, mutants, or mutant fragments thereof.
    Type: Application
    Filed: June 10, 2022
    Publication date: February 9, 2023
    Inventor: Demetrios BRADDOCK
  • TREATMENT OF DISEASES INVOLVING DEFICIENCY OF ENPP1 OR ENPP3
    Publication number: 20230031809
    Abstract: The present disclosure provides, among other things, vectors for expression of ENPP1 or ENPP3 in vivo and methods for the treatment of diseases of calcification and ossification in a subject.
    Type: Application
    Filed: August 25, 2022
    Publication date: February 2, 2023
    Inventors: Steven Jungles, Demetrios Braddock
  • Compositions and methods for stroke prevention in pediatric sickle cell anemia patients
    Patent number: 11390859
    Abstract: The present invention includes compositions and methods for treating stroke in sickle cell anemia (SCA) patients. In certain embodiments, the patient is administered certain ENPP1- or ENNP3-containing polypeptides, mutants, or mutant fragments thereof.
    Type: Grant
    Filed: August 3, 2017
    Date of Patent: July 19, 2022
    Assignee: Yale University
    Inventor: Demetrios Braddock
  • ENPP1 POLYPEPTIDES AND METHODS OF USING SAME
    Publication number: 20220195402
    Abstract: The present disclosure includes ENPP1 mutant polypeptides with improved in vivo half-lives.
    Type: Application
    Filed: April 3, 2020
    Publication date: June 23, 2022
    Inventors: Paul Stabach, Demetrios Braddock
  • Compositions and Methods for Treating Pathological Calcification and Ossification
    Publication number: 20220152163
    Abstract: The present invention includes compositions and methods for treating disease and disorders associated with pathological calcification or pathological ossification by modulating the level or activity of NPP1 or a mutant thereof, or a mutant NPP4 modified to exhibit ATP hydrolase activity similar to the hydrolase activity of NPP1.
    Type: Application
    Filed: January 28, 2022
    Publication date: May 19, 2022
    Inventors: Demetrios BRADDOCK, Ronald ALBRIGHT
  • Compositions for Treating Pathological Calcification Conditions, and Methods Using Same
    Publication number: 20220133854
    Abstract: The present invention includes compositions and methods for treating diseases or disorders associated with pathological calcification or pathological ossification. In certain embodiments, the diseases or disorders are selected from the group consisting of Generalized Arterial Calcification of Infancy (GACI), Idiopathic Infantile Arterial Calcification (IIAC), Ossification of the Posterior Longitudinal Ligament (OPLL), hypophosphatemic rickets, osteoarthritis, calcification of atherosclerotic plaques, PXE, hereditary and non-hereditary forms of osteoarthritis, ankylosing spondylitis, hardening of the arteries occurring with aging, calciphylaxis resulting from end stage renal disease and progeria.
    Type: Application
    Filed: July 7, 2021
    Publication date: May 5, 2022
    Inventors: Demetrios BRADDOCK, Ronald ALBRIGHT
  • ENPP1 Polypeptides and Methods of Using Same
    Publication number: 20220119782
    Abstract: The present invention includes ENPP1 polypeptides with improved in vivo half-lives. The invention further provides an ENPP1 polypeptide fusion comprising an ENPP1 polypeptide fused to a Fc region of an immunoglobulin, wherein the polypeptide fusion comprises at least one point mutation.
    Type: Application
    Filed: August 31, 2019
    Publication date: April 21, 2022
    Inventors: Paul Stabach, Demetrios Braddock
  • Compositions and methods for treating pathological calcification and ossification
    Patent number: 11266722
    Abstract: The present invention includes compositions and methods for treating disease and disorders associated with pathological calcification or pathological ossification by modulating the level or activity of NPP1 or a mutant thereof, or a mutant NPP4 modified to exhibit ATP hydrolase activity similar to the hydrolase activity of NPP1.
    Type: Grant
    Filed: March 9, 2020
    Date of Patent: March 8, 2022
    Assignee: Yale University
    Inventors: Demetrios Braddock, Ronald Albright