Abstract: An example system includes a fluid delivery device configured to deliver gas nanobubbles to a target site of a patient from a solution comprising a fluid, supersaturated with a. gas, wherein the fluid delivery' device defines a flow channel configured to flow the solution through the flow channel such that the gas in the supersaturated fluid forms gas nanobubbles as the solution flows through the flow channel towards the target site, and wherein the gas nanobubbles remain in the fluid at least until delivery' to the target site.

Abstract: Systems and methods for applying enhanced guided active compression decompression cardiopulmonary resuscitation are provided. Exemplary systems include a load cell, a handle, an adhesive pad. The handle and the adhesive pad are configured for magnetic coupling.

Abstract: Systems and methods for applying enhanced guided active compression decompression cardiopulmonary resuscitation are provided. Exemplary systems include a load cell, a handle, an adhesive pad. The handle and the adhesive pad are configured for magnetic coupling.

Abstract: Systems, devices, and techniques for controlling a compression unit associated with cardiopulmonary resuscitation (CPR) are described herein. For example, a medical system may include a compression unit configured to apply pressure to a torso region of a patient. The compression unit may be configured to move within space according to at least one degree of freedom. The medical system may further include processing circuitry configured to receive one or more sets of data representative of one or more patient parameters of the patient. Additionally, the medical system may generate, using a deep learning model, an output data set representing a predicted trajectory of at least one patient parameter of the one or more patient parameters, determine a set of control parameters, and control the compression unit to apply the pressure to the torso region of the patient.

Abstract: Gaseous nanobubbles are created and infused into the blood stream to therapeutic effect such as oxygenation. The nanobubbles may be created inside or outside of the patient, either during infusion or prior to infusion. CO2 is extracted from the blood to improve oxygen.

Abstract: Method of treating an individual following a period of ischemia are provided. The methods include administering inhaled agents postconditioning to the individual and optionally simultaneously performing cardiopulmonary resuscitation. The inhaled agents include at least one noble gas.

Abstract: A system includes an outer catheter and an inner catheter. The outer catheter has a proximal end and a distal end. The distal end has a discharge nozzle, a tapered interior wall, and an end orifice. The proximal end is configured to receive a fluid. The discharge nozzle is coupled to the proximal end by a first lumen. The discharge nozzle is configured to direct the fluid in a plurality of discrete streams aligned in a radial fashion about an axis of the first lumen. The interior catheter is configured for placement within the first lumen. A first end of the interior catheter includes an occluder and includes a first temperature sensor. The first temperature sensor is configured to pass through the end orifice. The occluder is configured to engage with the tapered interior wall in a fluid-tight seal. The first temperature sensor includes a sense surface and includes a signal node. The signal node is configured to provide a first signal corresponding to a timewise change in temperature at the sense surface.

Abstract: Systems and methods for applying enhanced guided active compression decompression cardiopulmonary resuscitation are provided. Exemplary systems include a load cell, a handle, an adhesive pad. The handle and the adhesive pad are configured for magnetic coupling.

Abstract: A system includes an outer catheter and an inner catheter. The outer catheter has a proximal end and a distal end. The distal end has a discharge nozzle, a tapered interior wall, and an end orifice. The proximal end is configured to receive a fluid. The discharge nozzle is coupled to the proximal end by a first lumen. The discharge nozzle is configured to direct the fluid in a plurality of discrete streams aligned in a radial fashion about an axis of the first lumen. The interior catheter is configured for placement within the first lumen. A first end of the interior catheter includes an occluder and includes a first temperature sensor. The first temperature sensor is configured to pass through the end orifice. The occluder is configured to engage with the tapered interior wall in a fluid-tight seal. The first temperature sensor includes a sense surface and includes a signal node. The signal node is configured to provide a first signal corresponding to a timewise change in temperature at the sense surface.

Abstract: Method of treating an individual following a period of ischemia are provided. The methods include administering inhaled agents postconditioning to the individual and optionally simultaneously performing cardiopulmonary resuscitation. The inhaled agents include at least one noble gas.

Abstract: Systems and methods for applying enhanced guided active compression decompression cardiopulmonary resuscitation are provided. Exemplary systems include a load cell, a handle, an adhesive pad. The handle and the adhesive pad are configured for magnetic coupling.

Abstract: According to an embodiment, a system for delivering a synthetic surfactant and an anesthetic to an individual to reduce reperfusion injury includes an anesthetic delivery device and a device for administering the synthetic surfactant intravenously or intraosseously. The anesthetic delivery device includes a patient connection mechanism for coupling with an airway of the individual, an intrathoracic pressure regulation (IPR) mechanism that involves changing the pressure in the airway that is coupled with the patient connection mechanism, and an anesthetic delivery mechanism for receiving the anesthetic and for delivering the anesthetic to the individual via the patient connection mechanism.

Abstract: According to one embodiment, a device for delivering an anesthetic to an individual to reduce reperfusion injury during the performance of cardiopulmonary resuscitation (CPR) is provided. The device includes a patient connection mechanism for coupling with an airway of the individual and an anesthetic delivery mechanism for receiving the anesthetic and for delivering the anesthetic to the individual via the patient connection mechanism. In some embodiments, the anesthetic is delivered with the assistance of an intrathoracic pressure regulation (IPR) mechanism or an impedance threshold device (ITD) coupled with the patient connection mechanism. The IPR mechanism may be configured to change a pressure in the airway and a thorax of the individual via application of a vacuum source. The ITD device may be configured to prevent respiratory gases from entering the lungs for at least some time during a decompression or relaxation phase of CPR.

Abstract: A method is provided for non-invasively lowering a person's ICP and increasing cerebral perfusion pressure. The method may include the step of actively lowering the person's intrathoracic pressure. Also, the person's effective circulating blood volume is lowered while the person's intrathoracic pressure is lowered to thereby non-invasively reduce venous blood volume in the brain to treat elevated intracranial pressure.

Abstract: Systems and methods for applying enhanced guided active compression decompression cardiopulmonary resuscitation are provided. Exemplary systems include a load cell, a handle, an adhesive pad. The handle and the adhesive pad are configured for magnetic coupling.

Abstract: A method is provided for resuscitating a patient from cardiac arrest. This may be done by (a) performing chest compressions for a first period of time at a depth of between about 1.5 to about 3 inches, and (b) ceasing chest compressions for a second period of time. Steps (a) and (b) may be repeated at least two times in order to prevent reperfusion injury after cardiac arrest.

Abstract: A method for increasing blood flow to vital organs during cardiopulmonary resuscitation of a person experiencing a cardiac arrest may include performing standard or active compression decompression cardiopulmonary resuscitation on a person to create artificial circulation by repetitively compressing the person's chest such that the person's chest is subject to a compression phase and a relaxation or decompression phase. The method may also include administering one or more vasodilator drugs to the person to improve the artificial circulation created by the cardiopulmonary resuscitation. The method may also include binding at least a portion of the person's abdomen, either manually or with an abdominal compression device. Performing cardiopulmonary resuscitation on a person may include ventilating the person with either an impedance threshold device or a intrathoracic pressure regulator.

Abstract: Systems and methods for enhancing circulation are described. In one particular embodiment, the invention provides a method for enhancing circulation. The method comprises attaching at least one compression device to at least a portion of a person's lower extremity. The person's chest is repetitively compressed so that the chest experiences a compression phase and a recoil phase or decompression. Also, the person's lower extremity is compressed using the compression device during at least some of the recoil phases.