Patents by Inventor Demosthenes Fokas

Demosthenes Fokas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Spiro[pyrrolidine-2,3?-oxindole] compounds and method of use
    Patent number: 6358750
    Abstract: The invention provides spiro[pyrrolidine-2,3′-oxindole] compounds and libraries of these compounds produced by the stereo- and regio-selective reaction of variously substituted isatins, &agr;-amino acids, and dipolarophiles (e.g., trans-chalcones, acrylate esters, or vinyl oxindoles). The new libraries can be assayed using any of many known screening procedures for activity, e.g., biological activity. For example, the libraries can be screened for activity as drugs (e.g., anticancer drugs, antibiotics, antiviral drugs, antiinflammatory drugs, analgesics, immunomodulators, neuroleptics, sedatives, stimulants, or diagnostic aids), bioseparation agents, or pesticides (e.g., herbicides, insecticides, or rodenticides).
    Type: Grant
    Filed: March 27, 2000
    Date of Patent: March 19, 2002
    Assignee: ArQule, Inc.
    Inventors: Demosthenes Fokas, David L. Coffen, William J. Ryan
  • Spiro[pyrrolidine-2,3'-oxindole] compounds and methods of use
    Patent number: 6114540
    Abstract: The invention provides spiro[pyrrolidine-2,3'-oxindole] compounds produced by the stereo- and regio-selective reaction of variously substituted isatins, .alpha.-amino acids, and dipolarophiles (e.g., trans-chalcones, acrylate esters, or vinyl oxindoles).
    Type: Grant
    Filed: September 8, 1998
    Date of Patent: September 5, 2000
    Assignee: ArQule, Inc.
    Inventors: Demosthenes Fokas, David L. Coffen, William J. Ryan