Abstract: The present invention discloses a compound shown in formula I or a stereoisomer, pharmaceutically acceptable salt, crystal form, solvate or isotopologue thereof. The compound of the present invention shows excellent inhibition activity against histone deacetylases, has remarkable inhibition effects on cancer cells, and provides a new choice of drugs used for the clinic treatment and diseases related to the abnormal activity of histone deacetylases.

Abstract: The invention provides a whole-granulation steel slag pavement base course material for a heavy-load pavement, which is prepared by uniformly mixing dry materials with water. The dry materials include a binder and a steel slag aggregate. The percentages in total mass of the binder and the steel slag aggregate are as follows: the binder is 3.4% to 5.0%, and the steel slag aggregate is 95.0% to 96.6%. The binder is prepared by mixing cement with steel slag micropowder according to a certain proportion, wherein the mass percentages of the cement and the steel slag micropowder are as follows: the cement is 70% to 90%, and the steel slag micropowder is 10% to 30%. The water accounts for 5% to 6% of the total mass of the dry materials.

Abstract: This invention relates a high pressure tube for hydraulic transmission consisting of the silicon rubber tube, the knitted fiber layer and the protective layer, the knitted fiber layer is fixed between the silicon rubber tube and the protective layer, which is characterized in that the material of the said silicon rubber tube is silicon rubber material KE581U; the said knitted layer is made by the knitting of terylene wire; the material of the said protective layer is silicon resin KR-166. The advantages summed up for this invention are in features of anti-ageing, anti-corrosion, withstanding high temperature, pliability, low shrinking ratio and environmental friendly, the said tube can be used for hydraulic transmission system in cases of very high pressure, the minimum explosive pressure reaches 15.5 MPa and the pressure under normal operation is 10 MPa at temperature of 20° C.