Patents by Inventor Dengmin Feng

Dengmin Feng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hemostatic paste and methods of making thereof
    Patent number: 11819384
    Abstract: The present invention is directed to a flowable hemostatic paste comprising a crosslinked carboxymethyl cellulose and at least one non-toxic dispersant. More specifically the present invention relates to a hemostatic paste containing citric acid cross-linked CMC, which is suspended or dispersed as a powder in a mixture of a first non-toxic glycerol-containing hygroscopic dispersant and a second non-toxic alcohol functionalized dispersant comprising propylene glycol or 1,3-butanediol.
    Type: Grant
    Filed: March 21, 2022
    Date of Patent: November 21, 2023
    Assignees: Guangzhou Bioseal Co., Ltd., Johnson & Johnson China Ltd., Ethicon, Inc.
    Inventors: Dengmin Feng, Ling Teng, Yanhui Zhang, Guojun Ni, Yufu Li, Xiang Wan
  • HEMOSTATIC PASTE AND USES THEREOF
    Publication number: 20230001048
    Abstract: Disclosed herein is a non-flowable and deformable hemostatic compositions comprised of a xerogel crosslinked powdered polysaccharide dispersed within a substantially anhydrous blend of: glycerol, and polyethylene glycol (PEG), wherein the PEG and glycerol are present in a ratio ranging from higher than 1:1.3: to below 1:2.7 by weight, respectively, and wherein the powder content in the composition is above 50%, by weight. Methods of making the non-flowable compositions, and uses of the compositions in methods for treating a wound or a bleeding tissue, such as bone tissue, are further disclosed.
    Type: Application
    Filed: December 25, 2019
    Publication date: January 5, 2023
    Inventors: LING TENG, TINGWAN XIE, YUAN TIAN, DENGMIN FENG, PEIQIU WANG
  • FLOWABLE FIBRINOGEN THROMBIN PASTE
    Publication number: 20220409705
    Abstract: Compositions comprised of: (i) a blend of fibrinogen, thrombin, wherein the blend is in the form of a plurality of particles, and (ii) a hydrophobic dispersant, wherein the composition is in the form of a paste at at-least one temperature in the range of 10° C., to 37° C., are disclosed herein. Methods for preparing a fibrin adhesive sealant in/on an injured tissue are further disclosed.
    Type: Application
    Filed: December 1, 2020
    Publication date: December 29, 2022
    Inventors: YUAN TIAN, HAI LI, DENGMIN FENG, LING TENG, YALIN WANG, YINGHUA CAI, PEIQIU WANG, TINGWAN XIE
  • Hemostatic paste and methods of making thereof
    Patent number: 11413192
    Abstract: The present invention is directed to a flowable hemostatic paste comprising a crosslinked carboxymethyl cellulose and at least one non-toxic dispersant. More specifically the present invention relates to a hemostatic paste containing citric acid cross-linked CMC, which is suspended or dispersed as a powder in a mixture of a first non-toxic glycerol-containing hygroscopic dispersant and a second non-toxic alcohol functionalized dispersant comprising propylene glycol or 1,3-butanediol.
    Type: Grant
    Filed: June 25, 2020
    Date of Patent: August 16, 2022
    Assignees: Guangzhou Bioseal Co., Ltd., Johnson & Johnson China Ltd., Ethicon Inc.
    Inventors: Dengmin Feng, Ling Teng, Yanhui Zhang, Guojun Ni, Yufu Li, Xiang Wan
  • HEMOSTATIC PASTE AND METHODS OF MAKING THEREOF
    Publication number: 20220202619
    Abstract: The present invention is directed to a flowable hemostatic paste comprising a crosslinked carboxymethyl cellulose and at least one non-toxic dispersant. More specifically the present invention relates to a hemostatic paste containing citric acid cross-linked CMC, which is suspended or dispersed as a powder in a mixture of a first non-toxic glycerol-containing hygroscopic dispersant and a second non-toxic alcohol functionalized dispersant comprising propylene glycol or 1,3-butanediol.
    Type: Application
    Filed: March 21, 2022
    Publication date: June 30, 2022
    Inventors: Dengmin Feng, Ling Teng, Yanhui Zhang, Guojun Ni, Yufu Li, Xiang Wan
  • HEMOSTATIC COMPOSITIONS AND METHODS OF MAKING THEREOF
    Publication number: 20220096708
    Abstract: The present invention is directed to hemostatic compositions comprising at least partially integrated agglomerated ORC fibers, fibrinogen, and thrombin and methods of forming a powdered hemostatic composition, comprising the steps of: forming a suspension of a mixture comprising particles of fibrinogen, thrombin, ORC fibers in a non-aqueous low boiling solvent; spraying the suspension through a nozzle onto a substrate, allowing the non-aqueous solvent to evaporate; separating from the substrate and sieving the composition.
    Type: Application
    Filed: December 13, 2021
    Publication date: March 31, 2022
    Inventors: Shuang Chen, Yufu Li, Dengmin Feng, Xiang Wan
  • METHODS AND COMPOSITIONS FOR MODIFIED FACTOR IX PROTEINS
    Publication number: 20220073894
    Abstract: Factor IX proteins are described with an increase in the number of glycosylation sites and other modifications to provide Factor IX proteins that have higher specific activity and a longer useful clotting function relative to wild type or non-modified Factor IX protein.
    Type: Application
    Filed: April 16, 2021
    Publication date: March 10, 2022
    Inventors: Darrel W. Stafford, Dengmin Feng
  • Hemostatic compositions and methods of making thereof
    Patent number: 11229720
    Abstract: The present invention is directed to hemostatic compositions comprising at least partially integrated agglomerated oxidized regenerated cellulose (ORC) fibers, fibrinogen, and thrombin and methods of forming a powdered hemostatic composition, comprising the steps of: forming a suspension of a mixture comprising particles of fibrinogen, thrombin, ORC fibers in a non-aqueous low boiling solvent; spraying the suspension through a nozzle onto a substrate, allowing the non-aqueous solvent to evaporate; separating from the substrate and sieving the composition.
    Type: Grant
    Filed: September 7, 2016
    Date of Patent: January 25, 2022
    Assignee: Guangzhou Bioseal Biotech Co., Ltd.
    Inventors: Shuang Chen, Yufu Li, Dengmin Feng, Xiang Wan
  • METHODS AND COMPOSITIONS FOR MODIFIED FACTOR IX PROTEINS
    Publication number: 20200362328
    Abstract: Factor IX proteins are described with an increase in the number of glycosylation sites and other modifications to provide Factor IX proteins that have higher specific activity and a longer useful clotting function relative to wild type or non-modified Factor IX protein.
    Type: Application
    Filed: December 17, 2019
    Publication date: November 19, 2020
    Inventors: Darrel W. Stafford, Dengmin Feng
  • HEMOSTATIC PASTE AND METHODS OF MAKING THEREOF
    Publication number: 20200323690
    Abstract: The present invention is directed to a flowable hemostatic paste comprising a crosslinked carboxymethyl cellulose and at least one non-toxic dispersant. More specifically the present invention relates to a hemostatic paste containing citric acid cross-linked CMC, which is suspended or dispersed as a powder in a mixture of a first non-toxic glycerol-containing hygroscopic dispersant and a second non-toxic alcohol functionalized dispersant comprising propylene glycol or 1,3-butanediol.
    Type: Application
    Filed: June 25, 2020
    Publication date: October 15, 2020
    Inventors: Dengmin Feng, Ling Teng, Yanhui Zhang, Guojun Ni, Yufu Li, Xiang Wan
  • Hemostatic paste and methods of making thereof
    Patent number: 10736786
    Abstract: The present invention is directed to a flowable hemostatic paste comprising a crosslinked carboxymethyl cellulose and at least one non-toxic dispersant. More specifically the present invention relates to a hemostatic paste containing citric acid cross-linked CMC, which is suspended or dispersed as a powder in a mixture of a first non-toxic glycerol-containing hygroscopic dispersant and a second non-toxic alcohol functionalized dispersant comprising propylene glycol or 1,3-butanediol.
    Type: Grant
    Filed: August 6, 2018
    Date of Patent: August 11, 2020
    Assignees: Guangzhou Bioseal Biotech Co., Ltd., Johnson & Johnson China Ltd., Ethicon, Inc.
    Inventors: Dengmin Feng, Ling Teng, Yanhui Zhang, Guojun Ni, Yufu Li, Xiang Wan
  • METHODS AND COMPOSITIONS FOR MODIFIED FACTOR IX PROTEINS
    Publication number: 20200095565
    Abstract: Factor IX proteins are described with an increase in the number of glycosylation sites and other modifications to provide Factor IX proteins that have higher specific activity and a longer useful clotting function relative to wild type or non-modified Factor IX protein.
    Type: Application
    Filed: May 2, 2019
    Publication date: March 26, 2020
    Inventors: Darrel W. Stafford, Dengmin Feng
  • HEMOSTATIC PASTE AND METHODS OF MAKING THEREOF
    Publication number: 20200022843
    Abstract: The present invention is directed to a flowable hemostatic paste comprising a crosslinked carboxymethyl cellulose and at least one non-toxic dispersant. More specifically the present invention relates to a hemostatic paste containing citric acid cross-linked CMC, which is suspended or dispersed as a powder in a mixture of a first non-toxic glycerol-containing hygroscopic dispersant and a second non-toxic alcohol functionalized dispersant comprising propylene glycol or 1,3-butanediol.
    Type: Application
    Filed: August 6, 2018
    Publication date: January 23, 2020
    Inventors: Dengmin Feng, Ling Teng, Yanhui Zhang, Guojun Ni, Yufu Li, Xiang Wan
  • METHODS AND COMPOSITIONS FOR MODIFIED FACTOR IX PROTEINS
    Publication number: 20190249164
    Abstract: Factor IX proteins are described with an increase in the number of glycosylation sites and other modifications to provide Factor IX proteins that have higher specific activity and a longer useful clotting function relative to wild type or non-modified Factor IX protein.
    Type: Application
    Filed: September 20, 2018
    Publication date: August 15, 2019
    Inventors: Darrel W. Stafford, Dengmin Feng
  • HEMOSTATIC COMPOSITIONS AND METHODS OF MAKING THEREOF
    Publication number: 20180043054
    Abstract: The present invention is directed to hemostatic compositions comprising at least partially integrated agglomerated ORC fibers, fibrinogen, and thrombin and methods of forming a powdered hemostatic composition, comprising the steps of: forming a suspension of a mixture comprising particles of fibrinogen, thrombin, ORC fibers in a non-aqueous low boiling solvent; spraying the suspension through a nozzle onto a substrate, allowing the non-aqueous solvent to evaporate; separating from the substrate and sieving the composition.
    Type: Application
    Filed: September 7, 2016
    Publication date: February 15, 2018
    Inventors: Shuang Chen, Yufu Li, Dengmin Feng, Xiang Wan
  • Chimeric factor VII molecules
    Patent number: 9238060
    Abstract: The present invention relates to chimeric Factor VII polypeptides and methods of using the same.
    Type: Grant
    Filed: February 10, 2014
    Date of Patent: January 19, 2016
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Darrel W. Stafford, Dengmin Feng
  • METHODS AND COMPOSITIONS FOR MODIFIED FACTOR IX PROTEINS
    Publication number: 20150307863
    Abstract: Factor IX proteins are described with an increase in the number of glycosylation sites and other modifications to provide Factor IX proteins that have higher specific activity and a longer useful clotting function relative to wild type or non-modified Factor IX protein.
    Type: Application
    Filed: November 20, 2013
    Publication date: October 29, 2015
    Inventors: Darrel W. Stafford, Dengmin Feng
  • CHIMERIC FACTOR VII MOLECULES
    Publication number: 20140302005
    Abstract: The present invention relates to chimeric Factor VII polypeptides and methods of using the same.
    Type: Application
    Filed: February 10, 2014
    Publication date: October 9, 2014
    Applicant: The University of North Carolina at Chapel Hill
    Inventors: Darrel W. Stafford, Dengmin Feng
  • Chimeric factor VII molecules
    Patent number: 8647620
    Abstract: The present invention relates to chimeric Factor VII polypeptides and methods of using the same.
    Type: Grant
    Filed: June 25, 2010
    Date of Patent: February 11, 2014
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Darrel W. Stafford, Dengmin Feng
  • CHIMERIC FACTOR VII MOLECULES WITH ENHANCED HALF LIFE AND METHODS OF USE
    Publication number: 20120064075
    Abstract: The present invention relates to novel proteins and methods of using chimeric Factor VIIa polypeptides.
    Type: Application
    Filed: April 29, 2011
    Publication date: March 15, 2012
    Inventors: Darrel W. Stafford, Dengmin Feng, David M. Mann