Abstract: The present invention relates to a thermoplastic polyurethane (TPU-1) obtained or obtainable by reaction of an isocyanate composition (IZ) comprising MDI with a polyol composition (PZ), wherein the polyol composition (PZ) comprises at least one polyol (P1) and a chain extender (KV1), wherein the polyol (P1) is selected from polytetrahydrofurans having an average molecular weight Mn in the range from 1200 to 2000 g/mol and the chain extender (KV1) is selected from the group consisting of 1,3-propanediol, 1,4-butanediol and 1,6-hexanediol and also to a process for producing a ski shoe or a part of a ski shoe from the thermoplastic polyurethane according to the invention and to the ski shoe or part of a ski shoe per se.

Abstract: The invention relates to a bipolar plate for a fuel cell stack that extends in a vertical plane in the use position, the plate comprising opposed first and second transverse edges, upper and lower longitudinal edges, a central region arranged between the edges, a first opening for a heat transfer fluid inlet, a second opening for heat transfer fluid collection a third opening for an oxidant inlet, a fourth opening for oxidant collection, a fifth opening for the inlet of a fuel, a sixth opening for fuel collection, wherein the first, third and sixth openings are arranged in the first transverse edge and are arranged axially in relation to one another, the second, fourth and fifth openings are arranged in the second transverse edge and are arranged axially in relation to one another, and, in the vertical position of use of the plate: the sixth opening are arranged below the first and third openings, the fourth opening is arranged below the second and fifth openings, and the second opening is arranged above the

Abstract: A composition contains a thermoplastic polyurethane (TPU-1), obtained or obtainable by reaction of an isocyanate composition (IZ) containing MDI with a polyol composition (PZ), and hollow glass microspheres. The polyol composition (PZ) contains at least one polyol (P1) selected from polytetrahydrofurans having an average molecular weight Mn in the range from 900 to 2,000 g/mol. The polyol composition (PZ) also contains a chain extender (KV1), selected from 1,2-ethandiol, 1,3-propanediol, 1,4-butanediol and 1,6-hexanediol. Ski shoes, preferably ski boots, particularly preferably the outer shell of a ski boot, can be based on such a thermoplastic polyurethane. Corresponding processes can be used for producing ski shoes.

Abstract: A composition contains a thermoplastic polyurethane (TPU-1), obtained or obtainable by reaction of an isocyanate composition (IZ) containing MDI with a polyol composition (PZ), and hollow glass microspheres. The polyol composition (PZ) contains at least one polyol (P1) selected from polytetrahydrofurans having an average molecular weight Mn in the range from 900 to 2,000 g/mol. The polyol composition (PZ) also contains a chain extender (KV1), selected from 1,2-ethandiol, 1,3-propanediol, 1,4-butanediol and 1,6-hexanediol. Ski shoes, preferably ski boots, particularly preferably the outer shell of a ski boot, can be based on such a thermoplastic polyurethane. Corresponding processes can be used for producing ski shoes.

Abstract: The present invention relates to a thermoplastic polyurethane (TPU-1) obtained or obtainable by reaction of an isocyanate composition (IZ) comprising MDI with a polyol composition (PZ), wherein the polyol composition (PZ) comprises at least one polyol (P1) and a chain extender (KV1), wherein the polyol (P1) is selected from polytetrahydrofurans having an average molecular weight Mn in the range from 1200 to 2000 g/mol and the chain extender (KV1) is selected from the group consisting of 1,3-propanediol, 1,4-butanediol and 1,6-hexanediol and also to a process for producing a ski shoe or a part of a ski shoe from the thermoplastic polyurethane according to the invention and to the ski shoe or part of a ski shoe per se.

Abstract: The present invention relates to polypeptide fragments comprising an amino-terminal fragment of the PA subunit of a viral RNA-dependent RNA polymerase or variants thereof possessing endonuclease activity, wherein said PA subunit is from a virus belonging to the Orthomyxoviridae family. This invention also relates to (i) crystals of the polypeptide fragments which are suitable for structure determination of said polypeptide fragments using X-ray crystallography and (ii) computational methods using the structural coordinates of said polypeptide to screen for and design compounds that modulate, preferably inhibit the endonucleolytically active site within the polypeptide fragment. In addition, this invention relates to methods identifying compounds that bind to the PA polypeptide fragments possessing endonuclease activity and preferably inhibit said endonucleolytic activity, preferably in a high throughput setting.

Abstract: The present invention relates to polypeptide fragments comprising an amino-terminal fragment of the PA subunit of a viral RNA-dependent RNA polymerase or variants thereof possessing endonuclease activity, wherein said PA subunit is from a virus belonging to the Orthomyxoviridae family. This invention also relates to (i) crystals of the polypeptide fragments which are suitable for structure determination of said polypeptide fragments using X-ray crystallography and (ii) computational methods using the structural coordinates of said polypeptide to screen for and design compounds that modulate, preferably inhibit the endonucleolytically active site within the polypeptide fragment. In addition, this invention relates to methods identifying compounds that bind to the PA polypeptide fragments possessing endonuclease activity and preferably inhibit said endonucleolytic activity, preferably in a high throughput setting.

Abstract: The present invention relates to polypeptide fragments comprising an amino-terminal fragment of the PA subunit of a viral RNA-dependent RNA polymerase or variants thereof possessing endonuclease activity, wherein said PA subunit is from a virus belonging to the Orthomyxoviridae family. This invention also relates to (i) crystals of the polypeptide fragments which are suitable for structure determination of said polypeptide fragments using X-ray crystallography and (ii) computational methods using the structural coordinates of said polypeptide to screen for and design compounds that modulate, preferably inhibit the endonucleolytically active site within the polypeptide fragment. In addition, this invention relates to methods identifying compounds that bind to the PA polypeptide fragments possessing endonuclease activity and preferably inhibit said endonucleolytic activity, preferably in a high throughput setting.

Abstract: The present invention relates to polypeptide fragments comprising an amino-terminal fragment of the PA subunit of a viral RNA-dependent RNA polymerase or variants thereof possessing endonuclease activity, wherein said PA subunit is from a virus belonging to the Orthomyxoviridae family. This invention also relates to (i) crystals of the polypeptide fragments which are suitable for structure determination of said polypeptide fragments using X-ray crystallography and (ii) computational methods using the structural coordinates of said polypeptide to screen for and design compounds that modulate, preferably inhibit the endonucleolytically active site within the polypeptide fragment. In addition, this invention relates to methods identifying compounds that bind to the PA polypeptide fragments possessing endonuclease activity and preferably inhibit said endonucleolytic activity, preferably in a high throughput setting.

Abstract: A process for the production of insulating coatings containing polyurethane groups and/or polyisocyanurate groups for hollow bodies by reaction of a) a polyisocyanate component with b) compounds which contain at least two hydrogen atoms which are active towards isocyanates and c) catalysts, optionally in the presence of d) further auxiliary substances and additives, characterised in that organic or mineral hollow microbeads having an average particle size in the range from 5 to 200 &mgr;m and a density in the range from 0.1 to 0.8 g/cm3 are added to at least one of components a) to d), is described. The use of these insulating coatings for pipes employed in the offshore sector is furthermore described.