Abstract: Methods for acquiring mass spectral data comprise determining first and second sets of m/z sub-ranges comprising respective first and second m/z sub-ranges. A sample is mass filtered to isolate ions in the first and second sets of m/z sub-ranges using respective mass filters. Mass analysis is performed to obtain first and second partial mass spectral data sets, the first and second mass filters having first and second response profiles having respective relatively high transmission regions and one or more relatively low transmission regions. The first and second sets of m/z sub-ranges are determined such that relatively high transmission regions of the first response profile and the second response profile at least partially overlap.

Abstract: Methods for acquiring mass spectral data of a sample across at least a portion of an m/z range comprise receiving mass spectral data across the m/z range and partitioning the m/z range into one or more sets of m/z sub-ranges, each set comprising one or more m/z sub-ranges, by dividing the m/z range into a plurality of m/z bins, determining an indication of ion abundance for each m/z bin, based on the mass spectral data, and forming an m/z sub-range of the one or more sets of m/z sub-ranges by assigning m/z bins having ion abundances that correspond to at least a threshold degree to the formed m/z sub-range. A mass analysis is performed on the sample for each set of m/z sub-ranges, thereby acquiring one or more partial mass spectral data sets.

Abstract: Methods for acquiring mass spectral data of a sample across at least a portion of an m/z range include receiving mass spectral data of the sample across the m/z range. The m/z range is partitioned into one or more sets of m/z sub-ranges, each set comprising one or more m/z sub-ranges, by dividing the m/z range into a plurality of m/z bins, determining an indication of ion abundance for each m/z bin, based on the mass spectral data, and forming an m/z sub-range of the one or more sets of m/z sub-ranges by assigning m/z bins having ion abundances that correspond to at least a threshold degree to the formed m/z sub-range. A mass analysis is performed on the sample for each set of m/z sub-ranges, thereby acquiring one or more partial mass spectral data sets.

Abstract: The present invention provides an electrode arrangement 10, 10? for an ion trap, ion filter, an ion guide, a reaction cell or an ion analyser. The electrode arrangement 10, 10? comprises an RF electrode 12a, 12b, 12a?, 12b? mechanically coupled to a dielectric material 11. The RF electrode 12a, 12b, 12a?, 12b? is mechanically coupled to the dielectric material 11 by a plurality of separators 13 that are spaced apart and configured to define a gap between the RF electrode 12a, 12b, 12a?, 12b? and the dielectric material 11. Each of the plurality of separators 13 comprises a projecting portion 13b and the dielectric material 11 comprises corresponding receiving portions 11a such that on coupling of the RF electrode 12a, 12b, 12a?, 12b? to the dielectric material 11, the projecting portion 13b of each separator 13 is received within the corresponding receiving portion 11a of the dielectric material 11.

Abstract: The present invention provides an electrode arrangement 10, 10? for an ion trap, ion filter, an ion guide, a reaction cell or an ion analyser. The electrode arrangement 10, 10? comprises an RF electrode 12a, 12b, 12a?, 12b? mechanically coupled to a dielectric material 11. The RF electrode 12a, 12b, 12a?, 12b? is mechanically coupled to the dielectric material 11 by a plurality of separators 13 that are spaced apart and configured to define a gap between the RF electrode 12a, 12b, 12a?, 12b? and the dielectric material 11. Each of the plurality of separators 13 comprises a projecting portion 13b and the dielectric material 11 comprises corresponding receiving portions 11a such that on coupling of the RF electrode 12a, 12b, 12a?, 12b? to the dielectric material 11, the projecting portion 13b of each separator 13 is received within the corresponding receiving portion 11a of the dielectric material 11.

Abstract: The present invention provides a mass spectrometer comprising a first ion trap, a second ion trap, a lens stack for directing ions from the first ion trap to the second ion trap and a housing. The first ion trap is arranged to form a linear or curved potential well and the second ion trap is an electrostatic ion trap, for example, an orbital ion trap, arranged to form an annular potential well. The mass spectrometer further comprises a unitary insert comprising a first cavity which holds the lens stack and a second cavity which holds the second ion trap, wherein the insert is inserted within the housing.

Abstract: The present invention provides an electrode arrangement 10, 10? for an ion trap, ion filter, an ion guide, a reaction cell or an ion analyser. The electrode arrangement 10, 10? comprises an RF electrode 12a, 12b, 12a?, 12b? mechanically coupled to a dielectric material 11 . The RF electrode 12a, 12b, 12a?, 12b? is mechanically coupled to the dielectric material 11 by a plurality of separators 13 that are spaced apart and configured to define a gap between the RF electrode 12a, 12b, 12a?, 12b? and the dielectric material 11. Each of the plurality of separators 13 comprises a projecting portion 13b and the dielectric material 11 comprises corresponding receiving portions 11a such that on coupling of the RF electrode 12a, 12b, 12a?, 12b? to the dielectric material 11, the projecting portion 13b of each separator 13 is received within the corresponding receiving portion 11a of the dielectric material 11.

Abstract: Disclosed herein is an ion supply system, having an ion source emitting ions into a fore vacuum chamber, an ion transport device having stacked electrodes arranged in the fore vacuum chamber, a control system supplying an oscillatory voltage to the electrodes of the ion transport device and a vacuum chamber, arranged downstream from the ion transport device. A vacuum gauge is arranged in the vacuum chamber. The pressure signal of the vacuum gauge is supplied to the control system supplying the oscillatory voltage to electrodes of the ion transport device. The control system adjusts the amplitude of the oscillatory voltage in accordance with the pressure signal.

Abstract: Disclosed herein is an ion supply system, having an ion source emitting ions into a fore vacuum chamber, an ion transport device having stacked electrodes arranged in the fore vacuum chamber, a control system supplying an oscillatory voltage to the electrodes of the ion transport device and a vacuum chamber, arranged downstream from the ion transport device. A vacuum gauge is arranged in the vacuum chamber. The pressure signal of the vacuum gauge is supplied to the control system supplying the oscillatory voltage to electrodes of the ion transport device. The control system adjusts the amplitude of the oscillatory voltage in accordance with the pressure signal.