Patents by Inventor Denis Durand
Denis Durand has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11369595Abstract: The present invention concerns a tryptophan metabolite chosen from kynurenic acid, anthranilic acid, quinolinic acid, picolinic acid, quinaldic acid and the mixtures of same or an enantiomer, diastereoisomer, hydrate, solvate, tautomer, racemic mixture or pharmaceutically acceptable salt of same, for use as a drug intended for increasing and/or maintaining muscle mass and/or strength in a mammal, and in particular intended for treating and/or preventing muscle atrophy in mammals and/or for promoting muscle growth in mammals doing exercise and aiming to increase muscle mass and/or quality and/or strength, for preventing the appearance of symptoms of sarcopenia or for rehabilitation following muscle loss and/or for improving recovery time after an intense physical effort.Type: GrantFiled: September 5, 2017Date of Patent: June 28, 2022Assignee: METABRAIN RESEARCHInventors: Sophie N. Raynal, Annick Audet, Valérie Autier, Christine Charon, Jean-Denis Durand, Micheline Kergoat
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Publication number: 20190247385Abstract: The present invention concerns a tryptophan metabolite chosen from kynurenic acid, anthranilic acid, quinolinic acid, picolinic acid, quinaldic acid and the mixtures of same or an enantiomer, diastereoisomer, hydrate, solvate, tautomer, racemic mixture or pharmaceutically acceptable salt of same, for use as a drug intended for increasing and/or maintaining muscle mass and/or strength in a mammal, and in particular intended for treating and/or preventing muscle atrophy in mammals and/or for promoting muscle growth in mammals doing exercise and aiming to increase muscle mass and/or quality and/or strength, for preventing the appearance of symptoms of sarcopenia or for rehabilitation following muscle loss and/or for improving recovery time after an intense physical effort.Type: ApplicationFiled: September 5, 2017Publication date: August 15, 2019Applicant: METABRAIN RESEARCHInventors: Sophie N. Raynal, Annick Audet, Valérie Autier, Christine Charon, Jean-Denis Durand, Micheline Kergoat
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Patent number: 10350184Abstract: This invention relates to oxime and alkoxy derivatives of the general formula (I), or an enantiomer, diastereoisomer, hydrate, solvate, tautomer, racemic mixture or pharmaceutically acceptable salt thereof for use as a medicament for the treatment and/or prevention of muscle atrophy in mammals and/or for limiting muscular atrophy in mammals and/or to promote muscle growth in exercising mammals aimed at increasing muscle mass and quality, preventing the occurrence of symptoms of sarcopenia related to age or rehabilitation after a muscle loss, age-related muscle atrophy and/or the consequences of drug therapy and/or immobilization and/or cachexia.Type: GrantFiled: April 14, 2016Date of Patent: July 16, 2019Assignee: METABRAIN RESEARCHInventors: Sophie N. Raynal, Micheline R. Kergoat, Valerie Autier, Christine G. Charon, Jean-Denis Durand, Franck F. Lepifre, Annick M. Audet
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Patent number: 10316056Abstract: Chemical compounds and the therapeutic use thereof, in particular for improving muscular quality in mammals. More particularly, a method of improving muscular quality in sarcopenic mammals and treating and/or preventing sarcopenia using the chemical compounds and, in particular, sarcopenic obesity and the associated complications and/or pathologies thereof, such as loss of strength, muscle mass, performance and of physical and movement capacity. Also, a method of improving muscle quality in obese mammals and treating and/or preventing of obesity and associated complications and/or pathologies, advantageously type 2 diabetes and metabolic syndrome, using the chemical compounds.Type: GrantFiled: April 9, 2018Date of Patent: June 11, 2019Assignees: BIOPHYTIS, SORBONNE UNVERSITÉInventors: René Lafont, Waly Dioh, Sophie Raynal, Stanislas Veillet, Franck Lepifre, Jean-Denis Durand
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Publication number: 20180327444Abstract: Chemical compounds and the therapeutic use thereof, in particular for improving muscular quality in mammals. More particularly, a method of improving muscular quality in sarcopenic mammals and treating and/or preventing sarcopenia using the chemical compounds and, in particular, sarcopenic obesity and the associated complications and/or pathologies thereof, such as loss of strength, muscle mass, performance and of physical and movement capacity. Also, a method of improving muscle quality in obese mammals and treating and/or preventing of obesity and associated complications and/or pathologies, advantageously type 2 diabetes and metabolic syndrome, using the chemical compounds.Type: ApplicationFiled: April 9, 2018Publication date: November 15, 2018Inventors: RENÉ LAFONT, WALY DIOH, SOPHIE RAYNAL, STANISLAS VEILLET, FRANCK LEPIFRE, JEAN-DENIS DURAND
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Publication number: 20180312100Abstract: An apparatus for securing an article includes a belt with a first connecting member and a free end. The belt has a lockable portion, which is located between the connecting member and the free end. An elongate resilient strap has a locking member which is located at a strap end and another connecting member is located at the other strap end. The locking member has a lockable end that locks the lockable portion.Type: ApplicationFiled: January 29, 2018Publication date: November 1, 2018Inventor: Denis DURAND
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Publication number: 20180303780Abstract: This invention relates to a derivative of the general formula (I), as follows: or an enantiomer, diastereoisomer, hydrate, solvate, tautomer, racemic mixture or pharmaceutically acceptable salt thereof for use as a medicament for the treatment and/or prevention of muscle atrophy in mammals and/or for limiting muscular atrophy in mammals and/or to promote muscle growth in exercising mammals aimed at increasing muscle mass and quality, preventing the occurrence of symptoms of sarcopenia related to age or rehabilitation after a muscle loss, age-related muscle atrophy and/or the consequences of drug therapy and/or immobilization and/or cachexia.Type: ApplicationFiled: April 14, 2016Publication date: October 25, 2018Inventors: Sophie N. RAYNAL, Micheline R. KERGOAT, Valerie AUTIER, Christine G. CHARON, Jean-Denis DURAND, Franck F. LEPIFRE, Annick M. AUDET
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Patent number: 9938315Abstract: Chemical compounds and the therapeutic use thereof, in particular for improving muscular quality in mammals. More particularly, a method of improving muscular quality in sarcopenic mammals and treating and/or preventing sarcopenia using the chemical compounds and, in particular, sarcopenic obesity and the associated complications and/or pathologies thereof, such as loss of strength, muscle mass, performance and of physical and movement capacity. Also, a method of improving muscle quality in obese mammals and treating and/or preventing of obesity and associated complications and/or pathologies, advantageously type 2 diabetes and metabolic syndrome, using the chemical compounds.Type: GrantFiled: May 20, 2015Date of Patent: April 10, 2018Assignees: BIOPHYTIS, UNIVERSITÉ PARIS 6 PIERRE ET MARIE CURIEInventors: René Lafont, Waly Dioh, Sophie Raynal, Stanislas Veillet, Franck Lepifre, Jean-Denis Durand
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Publication number: 20170226151Abstract: Chemical compounds and the therapeutic use thereof, in particular for improving muscular quality in mammals. More particularly, a method of improving muscular quality in sarcopenic mammals and treating and/or preventing sarcopenia using the chemical compounds and, in particular, sarcopenic obesity and the associated complications and/or pathologies thereof, such as loss of strength, muscle mass, performance and of physical and movement capacity. Also, a method of improving muscle quality in obese mammals and treating and/or preventing of obesity and associated complications and/or pathologies, advantageously type 2 diabetes and metabolic syndrome, using the chemical compounds.Type: ApplicationFiled: May 20, 2015Publication date: August 10, 2017Inventors: RENÉ LAFONT, WALY DIOH, SOPHIE RAYNAL, STANISLAS VEILLET, FRANCK LEPIFRE, JEAN-DENIS DURAND
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Patent number: 9365584Abstract: The invention relates to compounds that are direct activators of AMPK (AMP-activated protein kinase) and their use in the treatment of disorders regulated by activation of AMPK. For instance, compounds according to the invention are useful for the treatment of diabetes, metabolic syndrome, obesity, inflammation, cancer and cardiovascular diseases.Type: GrantFiled: December 28, 2010Date of Patent: June 14, 2016Assignee: PoxelInventors: Daniel Cravo, Sophie Hallakou-Bozec, Sébastien Bolze, Franck Lepifre, Laurent Faveriel, Jean-Denis Durand, Christine Charon
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Patent number: 9284329Abstract: Activators of AMPK and therapeutic uses thereof The invention relates to compounds that are direct activators of AMPK (AMP-activated protein kinase) and their use in the treatment of disorders regulated by activation of AMPK. For instance, compounds according to the invention are useful for the treatment of diabetes, metabolic syndrome, obesity, liver disease, hepatic steatosis, non alcoholic fatty liver disease (NAFLD), non alcoholic steato-hepatitis (NASH), liver fibrosis, dyslipidemia, hypertriglyceridemia, hypercholesterolemia, inflammation, cancer, cardiovascular diseases, atherosclerosis, high blood pressure, retinopathies or neuropathies.Type: GrantFiled: June 28, 2013Date of Patent: March 15, 2016Assignee: POXELInventors: Daniel Cravo, Sophie Hallakou-Bozec, Sébastien Bolze, Franck Lepifre, Laurent Faveriel, Jean-Denis Durand, Christine Charon
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Publication number: 20160016502Abstract: The ratchet strap binder includes a main frame and a spool mounted for rotation inside the main frame. In one possible implementation, the spool has an outer surface and includes a first strap-receiving passageway extending inside the spool between opposite first and second openings located on the outer surface of the spool, and a second strap-receiving passageway extending inside the spool from a third opening located on the outer surface of the spool to at least the first passageway. Also disclosed is a method of adjusting a strap in length and a ratchet strap binder including an elongated strap passing inside the at least one strap-receiving passageway, the strap forming a loop to adjust the strap in length. The loop can be pulled using a finger-actuated pull tab attached to the loop or be pulled directly by the user's fingers.Type: ApplicationFiled: September 28, 2015Publication date: January 21, 2016Inventor: Denis DURAND
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Patent number: 9162605Abstract: The ratchet strap binder includes a main frame and a spool mounted for rotation inside the main frame. In one possible implementation, the spool has an outer surface and includes a first strap-receiving passageway extending inside the spool between opposite first and second openings located on the outer surface of the spool, and a second strap-receiving passageway extending inside the spool from a third opening located on the outer surface of the spool to at least the first passageway. Also disclosed is a method of adjusting a strap in length and a ratchet strap binder including an elongated strap passing inside the at least one strap-receiving passageway, the strap forming a loop to adjust the strap in length. The loop can be pulled using a finger-actuated pull tab attached to the loop or be pulled directly by the user's fingers.Type: GrantFiled: August 16, 2013Date of Patent: October 20, 2015Assignee: 9269-1096 QUEBEC INC.Inventor: Denis Durand
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Publication number: 20150166566Abstract: Activators of AMPK and therapeutic uses thereof The invention relates to compounds that are direct activators of AMPK (AMP-activated protein kinase) and their use in the treatment of disorders regulated by activation of AMPK. For instance, compounds according to the invention are useful for the treatment of diabetes, metabolic syndrome, obesity, liver disease, hepatic steatosis, non alcoholic fatty liver disease (NAFLD), non alcoholic steato-hepatitis (NASH), liver fibrosis, dyslipidemia, hypertriglyceridemia, hypercholesterolemia, inflammation, cancer, cardiovascular diseases, atherosclerosis, high blood pressure, retinopathies or neuropathies.Type: ApplicationFiled: June 28, 2013Publication date: June 18, 2015Inventors: Daniel Cravo, Sophie Hallakou-Bozec, Sébastien Bolze, Franck Lepifre, Laurent Faveriel, Jean-Denis Durand, Christine Charon
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Publication number: 20130333169Abstract: The ratchet strap binder includes a main frame and a spool mounted for rotation inside the main frame. In one possible implementation, the spool has an outer surface and includes a first strap-receiving passageway extending inside the spool between opposite first and second openings located on the outer surface of the spool, and a second strap-receiving passageway extending inside the spool from a third opening located on the outer surface of the spool to at least the first passageway. Also disclosed is a method of adjusting a strap in length and a ratchet strap binder including an elongated strap passing inside the at least one strap-receiving passageway, the strap forming a loop to adjust the strap in length. The loop can be pulled using a finger-actuated pull tab attached to the loop or be pulled directly by the user's fingers.Type: ApplicationFiled: August 16, 2013Publication date: December 19, 2013Applicant: 9269-1096 QUEBEC INC.Inventor: Denis DURAND
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Patent number: 8480149Abstract: A hitch attached extension for over sized cargo has a longitudinally extending frame member adapted to be removably attached to a trailer hitch of a motor vehicle. The longitudinally extending frame member including a draw bar located at a distal end adapted to be connected with the trailer hitch, a pivot member adjacent the draw bar forming a pivot axis adapted to allow the longitudinally extending frame member to be pivoted between a horizontal position and a vertical stowing position with respect to the trailer hitch.Type: GrantFiled: February 7, 2011Date of Patent: July 9, 2013Assignee: 9269-1096 Quebec Inc.Inventor: Denis Durand
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Publication number: 20130053401Abstract: The invention relates to compounds that are direct activators of AMPK (AMP-activated protein kinase) and their use in the treatment of disorders regulated by activation of AMPK. For instance, compounds according to the invention are useful for the treatment of diabetes, metabolic syndrome, obesity, inflammation, cancer and cardiovascular diseases.Type: ApplicationFiled: December 28, 2010Publication date: February 28, 2013Inventors: Daniel Cravo, Sophie Hallakou-Bozec, Sébastien Bolze, Franck Lepifre, Laurent Faveriel, Jean-Denis Durand, Christine Charon
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Publication number: 20110193319Abstract: A hitch attached extension for over sized cargo has a longitudinally extending frame member adapted to be removably attached to a trailer hitch of a motor vehicle. The longitudinally extending frame member including a draw bar located at a distal end adapted to be connected with the trailer hitch, a pivot member adjacent the draw bar forming a pivot axis adapted to allow the longitudinally extending frame member to be pivoted between a horizontal position and a vertical stowing position with respect to the trailer hitch.Type: ApplicationFiled: February 7, 2011Publication date: August 11, 2011Inventor: Denis Durand