Patents by Inventor Denis Furling

Denis Furling has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NUCLEIC ACID SEQUENCE FOR REGULATION OF TRANSGENE EXPRESSION
    Publication number: 20220313843
    Abstract: The present invention relates to the field of gene therapy. In particular, the invention relates to a nucleic acid molecule comprising a nucleic acid sequence able to regulate the expression of a transgene of interest, to a vector or a cell comprising said nucleic acid molecule, and uses thereof.
    Type: Application
    Filed: September 11, 2020
    Publication date: October 6, 2022
    Inventors: DENIS FURLING, LUDOVIC ARANDEL, MAGDALENA MATLOKA, ALAIN SUREAU, MICHEL NEY
  • CONJUGATE AND USES THEREOF
    Publication number: 20220275372
    Abstract: The present invention relates to conjugates formed from a cell-penetrating peptide carrier linked to a therapeutic molecule, wherein the peptide carrier is defined by specific domains and the therapeutic molecule is a nucleic acid formed of trinucleotide repeats. The present invention further relates to the use of such a conjugate in methods of treatment or as a medicament, especially in the treatment of trinucleotide repeat disorders such as myotonic dystrophy (DM1).
    Type: Application
    Filed: August 7, 2020
    Publication date: September 1, 2022
    Applicants: OXFORD UNIVERSITY INNOVATION LIMITED, UNITED KINGDOM RESEARCH AND INNOVATION, ASSOCIATION INSTITUT DE MYOLOGIE, INSERM (INSTITUT NATONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), SORBONNE UNIVERSITE
    Inventors: Matthew Wood, Miguel Varela, Ashling Holland, Richard Raz, Denis Furling, Arnaud Klein, Michael Gait
  • TREATMENT OF MYOTONIC DYSTROPHY
    Publication number: 20210024597
    Abstract: The present invention relates to compositions and methods for treating myotonic dystrophy.
    Type: Application
    Filed: September 30, 2020
    Publication date: January 28, 2021
    Inventors: DENIS FURLING, NICOLAS SERGEANT, MARIE-LAURE CAILLET-BOUDIN, LUDOVIC ARANDEL
  • Treatment of myotonic dystrophy
    Patent number: 10799556
    Abstract: The present invention relates to compositions and methods for treating myotonic dystrophy.
    Type: Grant
    Filed: April 14, 2015
    Date of Patent: October 13, 2020
    Assignees: ASSOCIATION INSTITUT DE MYOLOGIE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
    Inventors: Denis Furling, Nicolas Sergeant, Marie-Laure Caillet-Boudin, Ludovic Arandel
  • Tricyclo-DNA antisense oligonucleotides, compositions, and methods for the treatment of disease
    Patent number: 10465191
    Abstract: Provided are tricyclo-DNA (tc-DNA) AON and methods employing tc-DNA AON for modifying splicing events that occur during pre-mRNA processing. Tricyclo-DNA (tc-DNA) AON are described that may be used to facilitate exon skipping or to mask intronic silencer sequences and/or terminal stein-loop sequences during pre-mRNA processing and to target RNase-mediated destruction of processed mRNA.
    Type: Grant
    Filed: February 9, 2017
    Date of Patent: November 5, 2019
    Assignees: ASSOCIATION INSTITUT DE MYOLOGIE, SORBONNE UNIVERSITE, UNIVERSITAT BERN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
    Inventors: Daniel Schumperli, Christian Leumann, Denis Furling, Luis Garcia, Thomas Voit
  • TRICYCLO-DNA ANTISENSE OLIGONUCLEOTIDES, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF DISEASE
    Publication number: 20170260524
    Abstract: Provided are tricyclo-DNA (tc-DNA) AON and methods employing tc-DNA AON for modifying splicing events that occur during pre-mRNA processing. Tricyclo-DNA (tc-DNA) AON are described that may be used to facilitate exon skipping or to mask intronic silencer sequences and/or terminal stein-loop sequences during pre-mRNA processing and to target RNase-mediated destruction of processed mRNA.
    Type: Application
    Filed: February 9, 2017
    Publication date: September 14, 2017
    Inventors: Daniel SCHUMPERLI, Christian LEUMANN, Denis FURLING, Luis GARCIA, Thomas VOIT
  • TREATMENT OF MYOTONIC DYSTROPHY
    Publication number: 20170035841
    Abstract: The present invention relates to compositions and methods for treating myotonic dystrophy.
    Type: Application
    Filed: April 14, 2015
    Publication date: February 9, 2017
    Inventors: DENIS FURLING, NICOLAS SERGEANT, MARIE-LAURE CAILLET-BOUDIN, LUDOVIC ARANDEL
  • Modified U7 snRNAs for treatment of neuromuscular diseases
    Patent number: 9080170
    Abstract: The present invention relates to a method to improve the activity of engineered U7 snRNAs used in the context of RNA-based therapeutics; particularly in exon skipping, exon inclusion, and mRNA eradication strategies. The resulting modified U7 snRNAs are useful for treating neuromuscular diseases, in particular Duchenne neuromuscular dystrophy, myotonic dystrophy DM1 and spinal muscular atrophy.
    Type: Grant
    Filed: March 17, 2011
    Date of Patent: July 14, 2015
    Assignee: ASSOCIATION INSTITUT DE MYOLOGIE
    Inventors: Luis Garcia, Denis Furling, Cyriaque Beley, Thomas Voit
  • MODIFIED U7 SNRNAS FOR TREATMENT OF NEUROMUSCULAR DISEASES
    Publication number: 20130045538
    Abstract: The present invention relates to a method to improve the activity of engineered U7 snRNAs used in the context of RNA-based therapeutics; particularly in exon skipping, exon inclusion, and mRNA eradication strategies. The resulting modified snRNAs are useful for treating neuromuscular diseases, in particular Duchenne neuromuscular dystrophy, myotonic dystrophy DM1 and spinal muscular atrophy.
    Type: Application
    Filed: March 17, 2011
    Publication date: February 21, 2013
    Applicant: ASSOCIATION INSTITUT DE MYOLOGIE
    Inventors: Luis Garcia, Denis Furling, Cyriaque Beley, Thomas Voit
  • TRICYCLO-DNA ANTISENSE OLIGONUCLEOTIDES, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF DISEASE
    Publication number: 20120149756
    Abstract: Provided are tricyclo-DNA (tc-DNA) AON and methods employing tc-DNA AON for modifying splicing events that occur during pre-mRNA processing. Tricyclo-DNA (tc-DNA) AON are described that may be used to facilitate exon skipping or to mask intronic silencer sequences and/or terminal stem-loop sequences during pre-mRNA processing and to target RNase-mediated destruction of processed mRNA.
    Type: Application
    Filed: April 9, 2010
    Publication date: June 14, 2012
    Applicants: Associatin Institut de Myologie, Centre National De La Recherche Scientifique, Universitât Bern, Universite Pierre et Marie Curie
    Inventors: Daniel Schümperli, Christian Leumann, Denis Furling, Luis Garcia, Thomas Voit