Abstract: A method is described for predicting a pain response in a subject suffering from cancer-induced bone pain (CIBP). Data is collected from the subject by querying the subject on personality and/or health traits, and/or performing one or more social learning and/or (bio)physical tests by or on the subject. The data is used in a set of mathematical models to attribute one or more Scoring Factors to the subject. The Scoring Factor is a measure of the propensity of the subject to raise a response to a pain stimulus or a treatment strategy; and/or a measure of the intensity of the response of the subject.