Patents by Inventor Denis John Kertesz

Denis John Kertesz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phenylacetic acid compounds
    Patent number: 7608731
    Abstract: The present invention provides a process for the preparation 6-[3-(hetero)aryloxy-2-fluoro-benzyl]-2H-pyridazin-3-one compounds 1 where R2 is an optionally substituted aryl or an optionally substituted heteroaryl, R6 is NO2, NH2, alkyl, halogen, or a function group readily derived therefrom and R4c is hydrogen or alkyl. There also is provided a process for the preparation of phenylacetic acid compounds 2, wherein R2 and R6 are as defined previously and R5a is hydrogen or alkyl, which are useful for the preparation of pyridazinone compounds.
    Type: Grant
    Filed: October 23, 2007
    Date of Patent: October 27, 2009
    Assignee: Roche Palo Alto LLC
    Inventors: Denis John Kertesz, Michael Martin, Wylie Solang Palmer
  • Process for preparing 3-aryloxy-phenylacetic acid compounds
    Patent number: 7291729
    Abstract: The present invention provides a process for the preparation of phenylacetic acid compounds 2 where R2 is an optionally substituted aryl, R6 is NO2, NH2, alkyl, halogen, or a function group readily derived there from and R4a is hydrogen C1-6 alkyl, tert-butyl or benzyl The compounds of formula 2a are useful intermediates for the preparation of HIV reverse transcriptase inhibitors
    Type: Grant
    Filed: April 14, 2005
    Date of Patent: November 6, 2007
    Assignee: Roche Palo Alto LLC
    Inventors: Denis John Kertesz, Michael Martin, Wylie Solang Palmer
  • Cyclic amine derivatives-CCR-3 receptor antagonists
    Patent number: 6984637
    Abstract: This invention relates to certain cyclic amine derivatives of Formula (I) that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
    Type: Grant
    Filed: November 21, 2003
    Date of Patent: January 10, 2006
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Leyi Gong, Denis John Kertesz, David Bernard Smith, Francisco Xavier Talamas, Robert Stephen Wilhelm
  • Piperidine CCR-3 receptor antagonists
    Patent number: 6977265
    Abstract: The invention provides compounds of Formula (I): wherein: R1-R5, A, L, and X have any of the values defined in the specification that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use, and methods and intermediates useful for preparing them.
    Type: Grant
    Filed: November 29, 2002
    Date of Patent: December 20, 2005
    Assignee: Roche Palo Alto LLC
    Inventors: Daisy Joe Du Bois, Denis John Kertesz, Eric Brian Sjogren, David Bernard Smith, Beihan Wang
  • Piperazine CCR-3 receptor antagonists
    Patent number: 6906073
    Abstract: The invention provides compounds of Formula (I): wherein: R1-R4, A, L, and X have any of the values defined in the specification that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use, and methods and intermediates useful for preparing them.
    Type: Grant
    Filed: November 29, 2002
    Date of Patent: June 14, 2005
    Assignee: Roche Palo Alto LLC
    Inventors: Daisy Joe Du Bois, Denis John Kertesz, Eric Brian Sjogren, David Bernard Smith, Beihan Wang
  • Alkyl urea retinoid agonists
    Patent number: 6844466
    Abstract: The current invention provide novel compounds, methods of treating or preventing emphysema, cancer and dermatological disorders, pharmaceutical compositions suitable for the treatment or prevention of emphysema, cancer and dermatological disorders and methods for delivering formulations into the lung of a mammal suffering from emphysema, cancer and dermatological disorders.
    Type: Grant
    Filed: September 17, 2002
    Date of Patent: January 18, 2005
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Paula Nanette Belloni, Denis John Kertesz, Michael Klaus, Jean-Marc Lapierre
  • Cyclic amine derivatives-CCR-3 receptor antagonists
    Publication number: 20040266782
    Abstract: This invention relates to certain cyclic amine derivatives of Formula (I) 1
    Type: Application
    Filed: November 21, 2003
    Publication date: December 30, 2004
    Inventors: Leyi Gong, Denis John Kertesz, David Bernard Smith, Francisco Xavier Talamas, Robert Stephen Wilhelm
  • Cyclic amine derivatives-CCR-3 receptor antagonists
    Patent number: 6770650
    Abstract: This invention relates to certain cyclic amine derivatives of Formula (I) that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
    Type: Grant
    Filed: August 29, 2001
    Date of Patent: August 3, 2004
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Leyi Gong, Donald Roy Hirschfeld, Denis John Kertesz, David Bernard Smith, Francisco Xavier Talamas, Robert Stephen Wilhelm
  • Cyclic amine derivatives-CCR-3 receptor antagonists
    Patent number: 6683074
    Abstract: This invention relates to certain cyclic amine derivatives of Formula (I) that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
    Type: Grant
    Filed: September 26, 2001
    Date of Patent: January 27, 2004
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Leyi Gong, Denis John Kertesz, David Bernard Smith, Francisco Xavier Talamas, Robert Stephen Wilhelm
  • Piperidine CCR-3 receptor antagonists
    Publication number: 20030229121
    Abstract: The invention provides compounds of Formula (I): 1
    Type: Application
    Filed: November 29, 2002
    Publication date: December 11, 2003
    Applicant: Syntex (U.S.A.) LLC
    Inventors: Daisy Joe Du Bois, Denis John Kertesz, Eric Brian Sjogren, David Bernard Smith, Beihan Wang
  • 2,4-substituted pyrrolidine derivatives-CCR-3 receptor antagonists
    Publication number: 20030199532
    Abstract: This invention relates to certain 2,4-substituted pyrrolidine derivatives that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
    Type: Application
    Filed: February 18, 2003
    Publication date: October 23, 2003
    Inventors: Denis John Kertesz, Michael Garret Roepel
  • Piperazine CCR-3 receptor antagonists
    Publication number: 20030176441
    Abstract: The invention provides compounds of Formula (I): 1
    Type: Application
    Filed: November 29, 2002
    Publication date: September 18, 2003
    Inventors: Daisy Joe Du Bois, Denis John Kertesz, Eric Brian Sjogren, David Bernard Smith, Beihan Wang
  • Alkyl urea retinoid agonists
    Publication number: 20030158226
    Abstract: The current invention provide novel compounds, methods of treating or preventing emphysema, cancer and dermatological disorders, pharmaceutical compositions suitable for the treatment or prevention of emphysema, cancer and dermatological disorders and methods for delivering formulations into the lung of a mammal suffering from emphysema, cancer and dermatological disorders.
    Type: Application
    Filed: September 17, 2002
    Publication date: August 21, 2003
    Applicant: Roche Bioscience, a division of Syntex (U.S.A.) LLC
    Inventors: Paula Nanette Belloni, Denis John Kertesz, Michael Klaus, Jean-Marc Lapierre
  • Cyclic amine derivatives-CCR-3 receptor antagonists
    Publication number: 20030153577
    Abstract: This invention relates to certain cyclic amine derivatives of Formula (I) 1
    Type: Application
    Filed: August 29, 2001
    Publication date: August 14, 2003
    Applicant: Roche Bioscience
    Inventors: Leyi Gong, Donald Roy Hirschfeld, Denis John Kertesz, David Bernard Smith, Francisco Xavier Talamas, Robert Stephen Wilhelm
  • 2,4-substituted pyrrolidine derivatives-CCR-3 receptor antagonists
    Patent number: 6552028
    Abstract: This invention relates to certain 2,4-substituted pyrrolidine derivatives that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
    Type: Grant
    Filed: December 19, 2001
    Date of Patent: April 22, 2003
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Denis John Kertesz, Michael Garret Roepel
  • 2,4-substituted pyrrolidine derivatives-CCR-3 receptor antagonists
    Publication number: 20020198255
    Abstract: This invention relates to certain 2,4-substituted pyrrolidine derivatives that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
    Type: Application
    Filed: December 19, 2001
    Publication date: December 26, 2002
    Inventors: Denis John Kertesz, Michael Garret Roepel
  • Piperidine quaternary salts- CCR- 3 receptor antagonists
    Patent number: 6342509
    Abstract: This invention relates to certain piperidine quatemrwy salts of Formula (I): that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
    Type: Grant
    Filed: November 18, 1999
    Date of Patent: January 29, 2002
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Donald Roy Hirschfeld, Denis John Kertesz, David Berard Smith
  • Cyclic amine derivatives-CCR-3 receptor antagonists
    Patent number: 6339087
    Abstract: This invention relates to certain cyclic amine derivatives of Formula (I) that are CCR-3 receptor antagonist, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
    Type: Grant
    Filed: November 20, 1998
    Date of Patent: January 15, 2002
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Leyi Gong, Denis John Kertesz, David Bernard Smith, Francisco Xavier Talamas, Robert Stephen Wilhelm
  • Cyclic amine derivatives- CCR-3 receptor antagonists
    Patent number: 6323223
    Abstract: This invention relates to certain cyclic amine derivatives of Formula (I) that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
    Type: Grant
    Filed: August 14, 1998
    Date of Patent: November 27, 2001
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Leyi Gong, Denis John Kertesz, David Bernard Smith, Francisco Xavier Talamas, Robert Stephen Wilhelm
  • 4-aroylpiperidine derivatives-CCR-3 receptor antagonists
    Patent number: 6140344
    Abstract: This invention relates to certain piperidine quaternary salts of Formula (I) ##STR1## that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
    Type: Grant
    Filed: November 17, 1999
    Date of Patent: October 31, 2000
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Leyi Gong, Denis John Kertesz, David Berard Smith, Robert Stephen Wilhelm