Patents by Inventor Denis M. Callewaert

Denis M. Callewaert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10161928
    Abstract: A panel for monitoring levels of biomarkers, including an assay having at least one inflammation monitoring test, at least one oxidative stress monitoring test, and at least one antioxidant activity monitoring test. A method of monitoring an individual's health, by collecting a sample from the individual, applying the sample to an assay panel, performing at least one inflammation monitoring test, at least one oxidative stress monitoring test, and at least one antioxidant activity monitoring test in the panel, and determining levels of biomarkers related to inflammation, oxidative stress, and antioxidant activity and therefore providing information regarding the individual's relative health and/or risk of developing one or more diseases.
    Type: Grant
    Filed: July 21, 2011
    Date of Patent: December 25, 2018
    Assignee: Wellmetris, LLC
    Inventors: Andrew A. Dahl, Denis M. Callewaert
  • Patent number: 9486005
    Abstract: A method of treating hypercholesterolemia in mammals, by administering an effective amount of a microbial fermentation product, and regulating genes involved in lipoprotein metabolism. A method of regulating cholesterol levels in a patient by administering an effective amount of a composition chosen from the group consisting of PAZ, specific components isolated from PAZ, chemically synthesized analogs of the components of PAZ, and regulating genes involved in lipoprotein metabolism. A method of treating high cholesterol levels in an individual by administering an effective amount of a microbial fermentation product, up-regulating the expression of at least one of the genes that encode ABCA1, ApoA1, and SRB1, and down-regulating the gene that encodes CETP. A method of preventing the onset of high cholesterol levels and/or a deleterious lipoprotein profile in an individual.
    Type: Grant
    Filed: February 22, 2011
    Date of Patent: November 8, 2016
    Inventors: Smiti Vaid Gupta, Enrique Martinez, II, Fazlul H. Sarkar, Denis M. Callewaert, Andreea Geamanu, Kevin Michael Patrie, Tiffany Capri Thomas, Andrew A. Dahl
  • Publication number: 20130122518
    Abstract: A panel for monitoring levels of biomarkers, including an assay having at least one inflammation monitoring test, at least one oxidative stress monitoring test, and at least one antioxidant activity monitoring test. A method of monitoring an individual's health, by collecting a sample from the individual, applying the sample to an assay panel, performing at least one inflammation monitoring test, at least one oxidative stress monitoring test, and at least one antioxidant activity monitoring test in the panel, and determining levels of biomarkers related to inflammation, oxidative stress, and antioxidant activity and therefore providing information regarding the individual's relative health and/or risk of developing one or more diseases.
    Type: Application
    Filed: July 21, 2011
    Publication date: May 16, 2013
    Applicant: WELLNESS INDICATORS, INC.
    Inventors: Denis M. Callewaert, Andrew A. Dahl
  • Publication number: 20120328598
    Abstract: A method of treating hypercholesterolemia in mammals, by administering an effective amount of a microbial fermentation product, and regulating genes involved in lipoprotein metabolism. A method of regulating cholesterol levels in a patient by administering an effective amount of a composition chosen from the group consisting of PAZ, specific components isolated from PAZ, chemically synthesized analogues of the components of PAZ, and regulating genes involved in lipoprotein metabolism. A method of treating high cholesterol levels in an individual by administering an effective amount of a microbial fermentation product, up-regulating the expression of at least one of the genes that encode ABCA1, ApoA1, and SRB1, and down-regulating the gene that encodes CETP. A method of preventing the onset of high cholesterol levels and/or a deleterious lipoprotein profile in an individual.
    Type: Application
    Filed: February 22, 2011
    Publication date: December 27, 2012
    Inventors: Smiti Vaid Gupta, Enrique Martinez, Fazlul H. Sarkar, Denis M. Callewaert, Andreea Geamanu, Kevin Michael Patrie, Tiffany Capri Thomas, Andrew A. Dahl
  • Publication number: 20110117122
    Abstract: The present invention discloses a composition and method for effecting various cytokines and NF-?B by administering an effective amount of a phyto-percolate composition to an individual. In various exemplary embodiments, the composition is claimed to be useful for the effective treatment of inflammation, cancer, and/or various infections including HIV by regulation of various interleukins, such as IL-10 and IL-2, and of transcription factors including NF-?B.
    Type: Application
    Filed: November 16, 2010
    Publication date: May 19, 2011
    Inventors: Tiffany Thomas, Fazlul Sarkar, Denis M. Callewaert, Andrew Dahl, Enrique Martinez
  • Patent number: 5891622
    Abstract: A method to assess oxidative stress in vivo by measuring the amount of free, esterified and glucuronidated forms of isoprostanes (8EPGF2) in a biological sample which contains the isoprostanes is disclosed. The method further includes determining the amount of total isoprostanes present in the sample. This amount is compared with a control sample. The oxidative stress is determined through the comparison wherein the amount of isoprostanes increase in the sample isolated from an organism undergoing oxidative stress compared to the control. Alternatively the method of the present invention provides for only the measurement of the glucuronidated form wherein the amount of glucuronidated isoprostanes increase in the sample isolated from an organism undergoing oxidative stress compared to the control.
    Type: Grant
    Filed: February 24, 1998
    Date of Patent: April 6, 1999
    Assignees: Oxford Biomedical Research, Inc., Vanderbilt University
    Inventors: Jason D. Morrow, Hyesook Kim, L. Jackson Roberts, II, Denis M. Callewaert
  • Patent number: 4604357
    Abstract: The invention relates to disinfectant urinal block means useful for collection of pooled urine and method of using the block means to provide in service release, of an antimicrobial agent component from the block means into the pool for effective inhibition of bacterial growth and consequent enzymatic degradation of wanted proteins contained in the pool.
    Type: Grant
    Filed: April 13, 1984
    Date of Patent: August 5, 1986
    Assignee: Enzymes of America
    Inventors: Denis M. Callewaert, Earl J. Braxton
  • Patent number: 4557863
    Abstract: The invention relates to a device useful when installed in a urinal for collection of urinary proteins. The adsorbent means includes a conduit for gravity feed passage of urine streams. The conduit has permeable layers in series containing a slow releasing antimicrobial agent and an adsorbent for urinary proteins such that for collection puropses wanted proteins are adsorbed without odor or loss due to bacterial degradation.
    Type: Grant
    Filed: April 13, 1984
    Date of Patent: December 10, 1985
    Inventors: Denis M. Callewaert, Earl J. Braxton