Patents by Inventor Denis Migliorini

Denis Migliorini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USE OF INHIBITORY CHIMERIC RECEPTORS TO PREVENT T CELL-INDUCED BLOOD BRAIN BARRIER DAMAGE
    Publication number: 20210230246
    Abstract: Neurotoxicity associated with CD19-targeted CAR-T therapy is reduced by including an inhibitory CAR (iCAR) in the CAR-T cell, wherein the iCAR specifically recognizes an antigen specific for or associated with neurovascular mural cells (e.g. pericytes or vSMC).
    Type: Application
    Filed: January 14, 2021
    Publication date: July 29, 2021
    Inventors: Avery Posey, Carl H. June, Denis Migliorini, Howard Chang, Ansuman Satpathy, Kevin Parker