Patents by Inventor Denis Pauze

Denis Pauze has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing and isolating 9-deoxo-9 (Z)-hydroxyiminoerythromycin A
    Patent number: 6590084
    Abstract: The present invention relates to a process for preparing 9-deoxo-9(Z)-hydroxyiminoerythromycin A corresponding to formula (I) below: from 9-deoxo-9(E)-hydroxyiminoerythromycin A by reaction with a base in water or in a mixture of water/solvent of dialkyl ketone type capable of forming a crystallizable solvate with the desired 9(Z)-oxime; acidification of the reaction mixture to a pH of between 9 and 11; addition to the said mixture of an organic solvent; optionally concentration under vacuum of the resulting organic phase; and isolation of the desired 9(Z)-erythromycin oxime.
    Type: Grant
    Filed: April 23, 2001
    Date of Patent: July 8, 2003
    Assignee: Merial
    Inventors: François Basset, Thierry Durand, Ronan Guevel, Patrick Leon, Frédéric Lhermitte, Gilles Oddon, Denis Pauze
  • Process for the preparation of 9-deoxo-8a-aza-(8a-alkyl)-8a-homoerythromycin A derivatives from 9-deoxo-9 (Z)-hydroxyiminoerythromycin A
    Patent number: 6482931
    Abstract: The invention provides a process for the preparation of 9-deoxo-8a-aza-8a-homoerythromycin A and of its 8a-alkylated derivatives from 9-deoxo-9(Z)-hydroxyiminoerythromycin A via a stereospecific Beckmann rearrangement in a reaction mixture using pyridine as main solvent, resulting in imidate intermediates which are not isolated from said mixture and which are employed directly in a reduction stage using a sufficient amount of borohydride, after extraction of the pyridine with a hydrocarbon which is miscible with the latter and in which said imidates are insoluble. The compound V can be directly N-alkylated at the 8a-position using an aldehyde without being isolated from the reduction mixture.
    Type: Grant
    Filed: March 22, 2001
    Date of Patent: November 19, 2002
    Assignee: Merial
    Inventors: Patrick Leon, Frederic Lhermitte, Gilles Oddon, Denis Pauze
  • Process of use in converting the 4?(S)-OH functional group of the cladinose unit of an azamacrolide to 4?(R)-NH2
    Patent number: 6353096
    Abstract: The subject-matter of the invention is a process for the stereoselective preparation of a compound of general formula I by stereoselective displacement by a nitrogenous nucleophilic compound of the activated alcohol functional group present at this 4″ position in a corresponding derivative of formula II.
    Type: Grant
    Filed: January 18, 2000
    Date of Patent: March 5, 2002
    Assignee: Merial
    Inventors: Patrick Leon, Frederic Lhermitte, Ronan Guevel, Denis Pauze, Laurent Garel, Gilles Oddon
  • Process for the preparation of 9-deoxo-8a-aza-(8a-alkyl)-8a-homoerythromycin A derivatives from 9-deoxo-9 (Z)-hydroxyiminoerythromycin A
    Publication number: 20010047088
    Abstract: The invention provides a process for the preparation of 9-deoxo-8a-aza-8a-homoerythromycin A 1
    Type: Application
    Filed: March 22, 2001
    Publication date: November 29, 2001
    Inventors: Patrick Leon, Frederic Lhermitte, Gilles Oddon, Denis Pauze
  • Process for preparing and isolating 9-deoxo-9 (Z)-hydroxyiminoerythromycin A
    Publication number: 20010034434
    Abstract: The present invention relates to a process for preparing 9-deoxo-9(Z)-hydroxyiminoerythromycin A corresponding to formula (I) below: 1
    Type: Application
    Filed: April 23, 2001
    Publication date: October 25, 2001
    Inventors: Francois Basset, Thierry Durand, Ronan Guevel, Patrick Leon, Frederic Lhermitte, Gilles Oddon, Denis Pauze
  • Process for preparing derivatives of the taxoid family
    Patent number: 5962705
    Abstract: The present invention relates to a novel process for preparing dialkoxy derivatives of the taxoid family by direct alkylation of the two positions 7 and 10 of deacetylbaccatin or derivatives thereof which are esterified in position 13.
    Type: Grant
    Filed: November 17, 1998
    Date of Patent: October 5, 1999
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Eric Didier, Gilles Oddon, Denis Pauze, Patrick Leon, Didier Riguet
  • Process of use in converting the 4?(S)-OH functional group of the cladinose unit of an azamacrolide to 4?(R)-NH2
    Patent number: RE40040
    Abstract: The subject-matter of the invention is a process for the stereoselective preparation of a compound of general formula I by stereoselective displacement by a nitrogenous nucleophilic compound of the activated alcohol functional group present at this 4? position in a corresponding derivative of formula II.
    Type: Grant
    Filed: September 9, 2005
    Date of Patent: January 29, 2008
    Assignee: Merial Limited
    Inventors: Patrick Leon, Frederic Lhermitte, Ronan Guevel, Denis Pauze, Laurent Garel, Gilles Oddon