Patents by Inventor Denis Roller
Denis Roller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8070714Abstract: The technical field of the invention is that of needleless pre-filled disposable syringes, operating with a gas generator, and used for intradermal, subcutaneous and intramuscular injections, of a liquid active principle for therapeutic use in human and veterinary medicine. The inventive needleless syringes use a reservoir (5) consisting of a tube (6) closed by an upstream plug-piston (7) and a downstream plug-piston (8) between which is contained the liquid active principle. Said needleless syringes are characterized in that they are capable of injecting a variable amount of liquid active principle (9) by adapting, through displacement of the downstream plug-piston (8) in the tube (6) the volume included between the two plug-pistons (7,8) to the amount of active principle (9) to be injected.Type: GrantFiled: February 29, 2008Date of Patent: December 6, 2011Assignee: CrossjectInventors: Patrick Alexandre, Bernard Brouquieres, Denis Roller
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Patent number: 7798989Abstract: The invention relates to needleless syringe for injecting an active liquid principle. The inventive syringe comprises a container (3) closed by a movable shutter and containing the injectable liquid. Said container is initially insulated from an injector-receptacle provided with a cylinder bore (10) in which a downstream shutter is arranged and which comprises at least one protuberance reducing the section with respect to the upstream opening of the bore. The aim of said invention is to damp and prevent the downstream shutter bounce when it is disposed in the bore (10) of the receptacle.Type: GrantFiled: January 11, 2005Date of Patent: September 21, 2010Assignee: CrossjectInventors: Patrick Alexandre, Georges Baud, Bernard Brouquieres, Laurent D'Emmanuelle, Denis Roller
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Patent number: 7587977Abstract: The invention relates to a microsystem and a method for fabricating a microsystem. The pyrotechnic microsystem (7, 1?) comprises a substrate having at least two separate electrical initiation zones, each of which provides separate electrical initiation of a pyrotechnic material deposited on the substrate. This microsystem (7, 1?) is characterized in that the same pyrotechnic material deposit (721, 721?, 13) covers both initiation zones, said deposit (721, 721?, 13) produced on the substrate having a thickness sufficiently small for the initiation of the pyrotechnic material in the initiation zone to remain localized and not propagate to the other initiation zone, but sufficient to generate a specific gas quantity.Type: GrantFiled: January 20, 2005Date of Patent: September 15, 2009Assignees: Biomerieux, SNPE Materiaux EnergetiquesInventors: Patrick Broyer, Bruno Colin, Denis Roller
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Publication number: 20080214997Abstract: The technical field of the invention is that of pre-filled and disposable needleless syringes, used for intradermal, subcutaneous and intramuscular injections of liquid active principle for therapeutic use in human and veterinary medicine. The inventive syringes (1) are mainly characterized in that they function with a pyrotechnic charge (6) consisting of a mixture of powder with high burning rate and a powder with low burning rate. Indeed, the combustion of the powder with a high burning rate enables to communicate instantly, through a piston (3), a very high speed to the active principle (4), whereas the combustion of the powder with a low burning rate enables to maintain a threshold pressure level to proceed with the injection, so as to ensure that the active principle (4) penetrates through the skin. Thus, the injection is properly and homogeneously without any loss of active liquid (4).Type: ApplicationFiled: March 6, 2008Publication date: September 4, 2008Applicant: CROSSJECTInventors: Patrick Alexandre, Patrick Cognot, Joel Lafforgue, Denis Roller
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Publication number: 20080154189Abstract: The technical field of the invention is that of needleless pre-filled disposable syringes, operating with a gas generator, and used for intradermal, subcutaneous and intramuscular injections, of a liquid active principle for therapeutic use in human and veterinary medicine. The inventive needleless syringes use a reservoir (5) consisting of a tube (6) closed by an upstream plug-piston (7) and a downstream plug-piston (8) between which is contained the liquid active principle. Said needleless syringes are characterized in that they are capable of injecting a variable amount of liquid active principle (9) by adapting, through displacement of the downstream plug-piston (8) in the tube (6) the volume included between the two plug-pistons (7,8) to the amount of active principle (9) to be injected.Type: ApplicationFiled: February 29, 2008Publication date: June 26, 2008Applicant: CROSSJECTInventors: Patrick Alexandre, Bernard Brouquieres, Denis Roller
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Patent number: 7357780Abstract: The technical field of the invention is that of pre-filled and disposable needleless syringes, used for intradermal, subcutaneous and intramuscular injections of liquid active principle for therapeutic use in human and veterinary medicine. The inventive syringes (1) are mainly characterized in that they function with a pyrotechnic charge (6) consisting of a mixture of powder with high burning rate and a powder with low burning rate. Indeed, the combustion of the powder with a high burning rate enables to communicate instantly, through a piston (3), a very high speed to the active principle (4), whereas the combustion of the powder with a low burning rate enables to maintain a threshold pressure level to proceed with the injection, so as to ensure that the active principle (4) penetrates through the skin. Thus, the injection is properly and homogeneously without any loss of active liquid (4).Type: GrantFiled: May 24, 2004Date of Patent: April 15, 2008Assignee: CrossjectInventors: Patrick Alexandre, Patrick Cognot, Joel Lafforgue, Denis Roller
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Publication number: 20080041259Abstract: The invention relates to a microsystem and a method for fabricating a microsystem. The pyrotechnic microsystem (7, 1?) comprises a substrate having at least two separate electrical initiation zones, each of which provides separate electrical initiation of a pyrotechnic material deposited on the substrate. This microsystem (7, 1?) is characterized in that the same pyrotechnic material deposit (721, 721?, 13) covers both initiation zones, said deposit (721, 721?, 13) produced on the substrate having a thickness sufficiently small for the initiation of the pyrotechnic material in the initiation zone to remain localized and not propagate to the other initiation zone, but sufficient to generate a specific gas quantity.Type: ApplicationFiled: January 20, 2005Publication date: February 21, 2008Applicants: BIOMERIEUX, SNPE MATERIAUX ENERGETIQUESInventors: Patrick Broyer, Bruno Colin, Denis Roller
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Publication number: 20080039780Abstract: The invention relates to needleless syringe for injecting an active liquid principle. The inventive syringe comprises a container (3) closed by a movable shutter and containing the injectable liquid. Said container is initially insulated from an injector-receptacle provided with a cylinder bore (10) in which a downstream shutter is arranged and which comprises at least one protuberance reducing the section with respect to the upstream opening of the bore. The aim of said invention is to damp and prevent the downstream shutter bounce when it is disposed in the bore (10) of the receptacle.Type: ApplicationFiled: January 11, 2005Publication date: February 14, 2008Applicant: CROSSJECTInventors: Patrick Alexandre, Georges Baud, Bernard Brouquieres, Laurent D'Emmanuelle, Denis Roller
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Patent number: 7270059Abstract: The invention relates to a device for the electrical initiation of at least one pyrotechnic microcharge (3), this device being characterized in that it comprises a support element having at least one conductive finger (6) connected to a first terminal of a central control unit (8), a second terminal of said central control unit (8) being intended to be electrically connected to an electrically conductive support for the pyrotechnic microcharge (3). The invention also relates to a microactuator (1, 1a, . . . , 1h) and a microsystem (1?) that use such an initiation device.Type: GrantFiled: April 9, 2004Date of Patent: September 18, 2007Assignees: SNPE Materiaux Energetiques, bioMerieuxInventors: Denis Roller, Patrick Broyer, Bruno Colin
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Patent number: 7159618Abstract: The invention relates to an electrically-opened micro fluid-valve. The inventive valve comprises: at least one planar support (12); at least one afferent microchannel (14); at least one efferent microchannel (16), said microchannels being arranged in the support (12); such that at least one of the ends (141 and 161) thereof touch the inner face (121) of the support close to one another; at least one deposit (18) of a heat-sensitive material which is disposed on the inner face (121) of the support (12); and at least one heating means (20). According to the invention, the aforementioned deposit (18) of heat-sensitive material at least partially seals the space separating the ends (141 and 161) of the microchannels (14 and 16), thereby preventing same from intercommunicating.Type: GrantFiled: June 15, 2004Date of Patent: January 9, 2007Assignees: Bio{acute over (m)}erieux, SNPE Matériaux EnergétiquesInventors: Patrick Broyer, Bruno Colin, Denis Roller
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Patent number: 7134445Abstract: The invention concerns the technical field of micro-actuators used for mechanical, chemical, electrical or thermal functions in microsystems, for microelectronic applications such as chips, or biomedical functions such as microfluidics integrating cards. The invention concerns a micro-actuator comprising a so-called main chamber, made in a solid support and containing a so-called main pyrotechnic charge, the main chamber being sealed and delimited by solid support walls and by a deformable membrane, such that the gases emitted by the combustion of the main pyrotechnic charge, enable the volume of the chamber to be increased by deforming the membrane while maintaining intact the solid walls of the main chamber. The invention is characterized in that it comprises means for evacuating the gases from the main chamber.Type: GrantFiled: November 18, 2003Date of Patent: November 14, 2006Assignees: bioMerieux, SNPE Materiaux EnergetiquesInventors: Patrick Broyer, Bruno Colin, Denis Roller
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Publication number: 20060180223Abstract: The present invention relates to an electrically openable microfluidic valve, which comprises: at least one plane support (12); at least one afferent microchannel (14); at least one efferent microchannel (16); said microchannels being provided in the support, so that at least one of their ends (141) and (161) opens onto the internal face (121) of said support (12), near one another; at least one deposit (18) of a heat-sensitive material laid out on the internal face (121) of the support (12); and at least one heating means (20); so that the deposit (18) of heat-sensitive material at least partly closes off the space separating the ends (141) and (161) of the microchannels (14) and (16), thus preventing the latter from communicating with one another; the increase in temperature by the heating means (20) resulting in a modification of the structure of the heat-sensitive material, thus at least partially clearing the ends of the microchannels and the space between the latter, so as to allow communicatiType: ApplicationFiled: June 15, 2004Publication date: August 17, 2006Applicants: bioMerieux, SNPE Materiaux EnergetiquesInventors: Patrick Broyer, Bruno Colin, Denis Roller
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Publication number: 20060096486Abstract: The invention relates to a device for the electrical initiation of at least one pyrotechnic microcharge (3), this device being characterized in that it comprises a support element having at least one conductive finger (6) connected to a first terminal of a central control unit (8), a second terminal of said central control unit (8) being intended to be electrically connected to an electrically conductive support for the pyrotechnic microcharge (3). The invention also relates to a microactuator (1, 1a, . . . , 1h) and a microsystem (1?) that use such an initiation device.Type: ApplicationFiled: April 9, 2004Publication date: May 11, 2006Applicants: SNPE Materiaux Energetiques, bioMerieuxInventors: Denis Roller, Patrick Broyer, Bruno Colin
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Patent number: 6994030Abstract: The technical field of the invention is that of microactuators designed for mechanical, chemical, electrical or thermal functions in microsystems, for microelectronic applications such as chips, or biomedical applications such as cards incorporating microfluidics. The invention concerns a microactuator comprising a chamber machined in a solid support and containing a pyrotechnic charge. Said microactuator is essentially characterised in that the chamber is partly delimited by a deformable membrane, such that the gases emitted by combustion of the pyrotechnic charge enable to increase the volume of said chamber by deforming said membrane while maintaining intact the solid walls of the chamber.Type: GrantFiled: April 23, 2002Date of Patent: February 7, 2006Assignee: SNPE Materlaux EnergetiquesInventors: Christian Perut, Denis Roller
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Publication number: 20050257829Abstract: The invention concerns the technical field of micro-actuators used for mechanical, chemical, electrical or thermal functions in microsystems, for microelectronic applications such as chips, or biomedical functions such as microfluidics integrating cards. the invention concerns a micro-actuator comprising a so-called main chamber, made in a solid support and containing a so-called main pyrotechnic charge, said main chamber being sealed and delimited by solid support walls and by a deformable membrane, such that the gases emitted by the combustion of the main pyrotechnic charge, enable the volume of said chamber to be increased by deforming said membrane while maintaining intact the solid walls of the main chamber. The invention is characterized in that it comprises means for evacuating the gases from the main chamber.Type: ApplicationFiled: November 18, 2003Publication date: November 24, 2005Applicant: BiomerieuxInventors: Patrick Broyer, Bruno Colin, Denis Roller
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Patent number: 6942645Abstract: A needleless syringe for injecting a liquid active principle. The syringe improves bioavailability by providing injection at two speed levels. The syringe includes a reservoir contained between an injector and push means subjected to the action of a gas generator. The push means including an end, directed towards the active principle, which forms a delivery head whereof the cross-section is smaller than the powering head cross-section, and the powering travel in the power cylinder is less than the height of the active principle reservoir.Type: GrantFiled: February 23, 2001Date of Patent: September 13, 2005Assignee: CrossjectInventors: Patrick Alexandre, Bernard Brouquieres, Philippe Gautier, Denis Roller
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Patent number: 6913593Abstract: The invention relates to a needleless syringe (1), comprising the following' successively: a gas generator, a gas expansion chamber (3), a means for retaining particles of the active agent and a tube (6) for ejecting said particles. The main characteristic of the inventive syringe is that the gas generator is a pyrotechnic generator (2), comprising a pyrotechnic charge (10) which generates gas, a gas generator and an initiation device. The invention is also characterized in that the retaining means comprise at least one lid (8), which is fixed to the ejection tube and is configured to break under the influence of the gases generated by the combustion of said charge (10).Type: GrantFiled: November 23, 2000Date of Patent: July 5, 2005Assignee: CrossjectInventors: Patrick Alexandre, Guy Delannoy, Philippe Gautier, Denis Roller
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Patent number: 6911015Abstract: The invention concerns a needleless syringe (1) comprising a trigger, a gas generator (2) prolonged by a gas expansion chamber (3), a system for retaining particles and an ejection tube (4). The invention is characterised in that the particles are housed outside the ejection tube conduit (4) and the gases cause the particles to reach inside said tube (4) by displacing a plunger (13), prior to speeding them up by wave shock inside the tube (4).Type: GrantFiled: December 18, 2000Date of Patent: June 28, 2005Assignee: CrossjectInventors: Patrick Alexandre, Georges Baud, Guy Delannoy, Denis Roller
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Publication number: 20050010167Abstract: The technical field of the invention is that of pre-filled and disposable needleless syringes, used for intradermal, subcutaneous and intramuscular injections of liquid active principle for therapeutic use in human and veterinary medicine. The inventive syringes (1) are mainly characterized in that they function with a pyrotechnic charge (6) consisting of a mixture of powder with high burning rate and a powder with low burning rate. Indeed, the combustion of the powder with a high burning rate enables to communicate instantly, through a piston (3), a very high speed to the active principle (4), whereas the combustion of the powder with a low burning rate enables to maintain a threshold pressure level to proceed with the injection, so as to ensure that the active principle (4) penetrates through the skin. Thus, the injection is properly and homogeneously without any loss of active liquid (4).Type: ApplicationFiled: May 24, 2004Publication date: January 13, 2005Applicant: CrossjectInventors: Patrick Alexandre, Patrick Cognot, Joel Lafforgue, Denis Roller
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Patent number: 6835187Abstract: The technical field of the invention is that of needleless syringes used for injecting active principles in powder form for therapeutic purposes. The invention concerns a needleless syringe (1) comprising successively a gas generator (2), a gas expanding chamber (3), means for retaining active particles and an ejection tube (4). The invention is characterised in that the particle retaining means consists of an inner seal (14) having at least a cavity (15), the inner seal (14) serves both to contain the active principle and to generate a shock wave when it is ruptured.Type: GrantFiled: September 4, 2002Date of Patent: December 28, 2004Assignee: CrossjectInventors: Patrick Alexandre, Georges Baud, Philippe Gautier, Denis Roller