Patents by Inventor Denis Wahler

Denis Wahler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230220431
    Abstract: There is provided SHC/HAC derivatives, amino acid sequences comprising the SHC/HAC derivatives, nucleotide sequences encoding the SHC/HAC derivatives, vectors comprising nucleotide sequences encoding the SHC/HAC derivatives, recombinant host cells comprising nucleotide sequences encoding the SHC/HAC derivatives and applications of the recombinant host cells comprising either SHC/HAC derivatives or WT SHC/HAC enzymes in methods to prepare (?)-Ambrox and SHC/HAC enzymes in methods to prepare (?)-Ambrox.
    Type: Application
    Filed: August 31, 2022
    Publication date: July 13, 2023
    Inventors: Eric EICHHORN, Boris SCHILLING, Denis WAHLER, Laurent FOURAGE, Esther LOCHER
  • Patent number: 11466299
    Abstract: There is provided SHC/HAC derivatives, amino acid sequences comprising the SHC/HAC derivatives, nucleotide sequences encoding the SHC/HAC derivatives, vectors comprising nucleotide sequences encoding the SHC/HAC derivatives, recombinant host cells comprising nucleotide sequences encoding the SHC/HAC derivatives and applications of the recombinant host cells comprising either SHC/HAC derivatives or WT SHC/HAC enzymes in methods to prepare (?)-Ambrox and SHC/HAC enzymes in methods to prepare (?)-Ambrox.
    Type: Grant
    Filed: April 26, 2021
    Date of Patent: October 11, 2022
    Assignee: GIVAUDAN S.A.
    Inventors: Eric Eichhorn, Boris Schilling, Denis Wahler, Laurent Fourage, Esther Locher
  • Publication number: 20210254112
    Abstract: There is provided SHC/HAC derivatives, amino acid sequences comprising the SHC/HAC derivatives, nucleotide sequences encoding the SHC/HAC derivatives, vectors comprising nucleotide sequences encoding the SHC/HAC derivatives, recombinant host cells comprising nucleotide sequences encoding the SHC/HAC derivatives and applications of the recombinant host cells comprising either SHC/HAC derivatives or WT SHC/HAC enzymes in methods to prepare (?)-Ambrox and SHC/HAC enzymes in methods to prepare (?)-Ambrox.
    Type: Application
    Filed: April 26, 2021
    Publication date: August 19, 2021
    Inventors: Eric EICHHORN, Boris SCHILLING, Denis WAHLER, Laurent FOURAGE, Esther LOCHER
  • Patent number: 11021722
    Abstract: There is provided SHC/HAC derivatives, amino acid sequences comprising the SHC/HAC derivatives, nucleotide sequences encoding the SHC/HAC derivatives, vectors comprising nucleotide sequences encoding the SHC/HAC derivatives, recombinant host cells comprising nucleotide sequences encoding the SHC/HAC derivatives and applications of the recombinant host cells comprising either SHC/HAC derivatives or WT SHC/HAC enzymes in methods to prepare (?)-Ambrox and SHC/HAC enzymes in methods to prepare (?)-Ambrox.
    Type: Grant
    Filed: October 10, 2019
    Date of Patent: June 1, 2021
    Assignee: GIVAUDAN S.A.
    Inventors: Eric Eichhorn, Boris Schilling, Denis Wahler, Laurent Fourage, Esther Locher
  • Publication number: 20200040369
    Abstract: There is provided SHC/HAC derivatives, amino acid sequences comprising the SHC/HAC derivatives, nucleotide sequences encoding the SHC/HAC derivatives, vectors comprising nucleotide sequences encoding the SHC/HAC derivatives, recombinant host cells comprising nucleotide sequences encoding the SHC/HAC derivatives and applications of the recombinant host cells comprising either SHC/HAC derivatives or WT SHC/HAC enzymes in methods to prepare (?)-Ambrox and SHC/HAC enzymes in methods to prepare (?)-Ambrox.
    Type: Application
    Filed: October 10, 2019
    Publication date: February 6, 2020
    Inventors: Eric EICHHORN, Boris SCHILLING, Denis WAHLER, Laurent FOURAGE, Esther LOCHER
  • Patent number: 10472655
    Abstract: There is provided SHC/HAC derivatives, amino acid sequences comprising the SHC/HAC derivatives, nucleotide sequences encoding the SHC/HAC derivatives, vectors comprising nucleotide sequences encoding the SHC/HAC derivatives, recombinant host cells comprising nucleotide sequences encoding the SHC/HAC derivatives and applications of the recombinant host cells comprising either SHC/HAC derivatives or WT SHC/HAC enzymes in methods to prepare (?)-Ambrox and SHC/HAC enzymes in methods to prepare (?)-Ambrox.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: November 12, 2019
    Assignee: GIVAUDAN S.A.
    Inventors: Eric Eichhorn, Boris Schilling, Denis Wahler, Laurent Fourage, Esther Locher
  • Publication number: 20180148751
    Abstract: There is provided SHC/HAC derivatives, amino acid sequences comprising the SHC/HAC derivatives, nucleotide sequences encoding the SHC/HAC derivatives, vectors comprising nucleotide sequences encoding the SHC/HAC derivatives, recombinant host cells comprising nucleotide sequences encoding the SHC/HAC derivatives and applications of the recombinant host cells comprising either SHC/HAC derivatives or WT SHC/HAC enzymes in methods to prepare (?)-Ambrox and SHC/HAC enzymes in methods to prepare (?)-Ambrox.
    Type: Application
    Filed: April 22, 2016
    Publication date: May 31, 2018
    Inventors: Eric EICHHORN, Boris SCHILLING, Denis WAHLER, Laurent FOURAGE, Esther LOCHER
  • Patent number: 9145570
    Abstract: The invention relates to an enzymatic acylation method including at least the following steps of: contacting at least one compound having at least one function selected from among the amine, alcohol, or thiol functions, at least one microorganism having an acyl transfer activity and/or an acyl transfer enzyme, and at least one acylphosphonate donor of formula (I), where: R is an alkyl, alkene, alkyne, aryl, or aralkyl radical, or is —ORa, —SRa, —NRaRb, where Ra and Rb are identical or different and are H, an alkyl, alkene, alkyne, aryl or aralkyl radical, the alkyl, alkene, alkyne, aryl or aralkyl radicals being optionally substituted; X is O or S; Y and Z, which are identical or different, are —OR1, —OR2, —SR1, —SR2, —NR?1R?1, —NR?2R?2; R1, R2, R?1, R?2, R?1 and R?2, which are identical or different, are an alkyl, alkene, alkyne, aryl or aralkyl radical, said alkyl, alkene, alkyne, aryl or aralkyl radicals being optionally substituted; and recovering the compound including at least one acyl function, said fu
    Type: Grant
    Filed: July 29, 2011
    Date of Patent: September 29, 2015
    Assignee: PCAS Biosolution
    Inventors: Juliette Martin, Gerard Guillamot, Laurent Fourage, Denis Wahler
  • Patent number: 8951771
    Abstract: Fatty acid 13-hydroperoxide lyase proteins which have been modified with respect to a previously described guava 13-hydroperoxide lyase and the nucleic acid sequences encoding these proteins. Also, recombinant nucleic acid molecules for expressing the modified 13-hydroperoxide lyases and methods of using such lyases in the field of organic synthesis.
    Type: Grant
    Filed: July 26, 2013
    Date of Patent: February 10, 2015
    Assignee: Firmenich SA
    Inventors: Fredi Bruhlmann, Laurent Fourage, Denis Wahler
  • Patent number: 8741593
    Abstract: This invention has as its object a method for releasing a product by subjecting a compound of Formula (II?): R?7R?8(HX)C1-C2(YH)R?9R?10 to a chemical oxidation that cleaves the bond C1-C2 to obtain the product. In the compound of Formula (II?): R?7 to R?10, which are identical or different, correspond to a hydrogen atom, a substituted or unsubstituted alkyl group, or a substituted or unsubstituted functional group; X and Y, which are identical or different, are an oxygen atom, a sulfur atom, or an amine of Formula —NR11R12, wherein R11 is a hydrogen atom, an alkyl group, or a substituted or unsubstituted aryl group, and R12 is not a hydrogen atom. The invention also has as its object a method for releasing a product that comprises, before the chemical oxidation stage, a first step for preparing the compound of Formula (II?). The released product can be a volatile molecule or an active substance or else a specific product.
    Type: Grant
    Filed: November 20, 2006
    Date of Patent: June 3, 2014
    Assignee: Proteus
    Inventors: Jean-Louis Reymond, Denis Wahler, Frabrizzio Badalassi, Hong-Khanh Nguyen
  • Publication number: 20140024092
    Abstract: Fatty acid 13-hydroperoxide lyase proteins which have been modified with respect to a previously described guava 13-hydroperoxide lyase and the nucleic acid sequences encoding these proteins. Also, recombinant nucleic acid molecules for expressing the modified 13-hydroperoxide lyases and methods of using such lyases in the field of organic synthesis.
    Type: Application
    Filed: July 26, 2013
    Publication date: January 23, 2014
    Inventors: Fredi Bruhlmann, Laurent Fourage, Denis Wahler
  • Patent number: 8501452
    Abstract: Fatty acid 13-hydroperoxide lyase proteins which have been modified with respect to a previously described guava 13-hydroperoxide lyase and the nucleic acid sequences encoding these proteins. Also, recombinant nucleic acid molecules for expressing the modified 13-hydroperoxide lyases and methods of using such lyases in the field of organic synthesis.
    Type: Grant
    Filed: June 25, 2008
    Date of Patent: August 6, 2013
    Assignee: Firmenich, SA
    Inventors: Fredi Brühlmann, Laurent Fourage, Denis Wahler
  • Publication number: 20130130337
    Abstract: The invention relates to an enzymatic acylation method including at least the following steps of: contacting at least one compound having at least one function selected from among the amine, alcohol, or thiol functions, at least one microorganism having an acyl transfer activity and/or an acyl transfer enzyme, and at least one acylphosphonate donor of formula (I), where: R is an alkyl, alkene, uikyne, aryl, or aralkyl radical, or is —ORa, —SRa, —NRaRb, where Ra and Rb are identical or different and are H, an alkyl, alkene, alkyne, aryl or aralkyl radical, the alkyl, alkene, alkyne, aryl or aralkyl radicals being optionally substituted; X is O or S; Y and Z, which are identical or different, are —OR1, —OR2, —SR1, —SR2, —NR?1R?1, —NR?2R?2; R1, R2, R?1, R?2, R?1 and R?2, which are identical or different, are an alkyl, alkene, alkyne, aryl or aralkyl radical, said alkyl, alkene, alkyne, aryl or aralkyl radicals being optionally substituted; and recovering the compound including at least one acyl function, said fu
    Type: Application
    Filed: July 29, 2011
    Publication date: May 23, 2013
    Applicant: PCAS BIOSOLUTION
    Inventors: Juliette Martin, Gerard Guillamot, Laurent Fourage, Denis Wahler
  • Publication number: 20100203586
    Abstract: Fatty acid 13-hydroperoxide lyase proteins which have been modified with respect to a previously described guava 13-hydroperoxide lyase and the nucleic acid sequences encoding these proteins. Also, recombinant nucleic acid molecules for expressing the modified 13-hydroperoxide lyases and methods of using such lyases in the field of organic synthesis.
    Type: Application
    Filed: June 25, 2008
    Publication date: August 12, 2010
    Inventors: Fredi Brühlmann, Laurent Fourage, Denis Wahler
  • Publication number: 20070264680
    Abstract: The present invention provides methods and test-kits for rapidly detecting and/or quantifying a group of organism, cultivable or not cultivable, sharing the same enzymatic activity. In particular, the methods and kits can be used for example in the field of cosmetics, where the activities of (microbial) enzymes, which are responsible for malodor or dandruff, are detected as an indicator for the presence of particular groups of microorganisms. Furthermore, the effect on substances acting on the causative microbes can be determined rapidly, easily and at low cost.
    Type: Application
    Filed: March 21, 2005
    Publication date: November 15, 2007
    Applicant: PROTEUS S.A.
    Inventors: Petra Allef, Burghard Gruning, Gilles Ravot, Denis Wahler
  • Patent number: 7258972
    Abstract: This invention has as its object a process for generating the idiosyncratic catalytic imprint of a sample, characterized in that it comprises the following stages: the sample that is likely to have the catalytic activity is brought into contact with a group of substrates; the signals that are generated after said contact are captured in some way. Advantageously, after the signals are captured, a processing of the latter that consists of assigning to each signal a digital value constituting a component of a graphic display, for example a color display, of the idiosyncratic imprint is carried out.
    Type: Grant
    Filed: May 10, 2004
    Date of Patent: August 21, 2007
    Assignees: Proteus, Universite de Berne
    Inventors: Jean-Louis Reymond, Denis Wahler
  • Patent number: 7238483
    Abstract: This invention has as its object a method for detecting catalytic activity of a sample, characterized in that it comprises: the incubation of a substrate (S) with the sample that may have the catalytic activity that it is desired to detect, the addition of a reagent (X) that can react either with a chemical group of unconsumed substrate (S) or with a chemical group of product (P) that is formed after an incubation period with the sample, the addition of a developer (R) that can react with reagent (X), and the detection of the transformation of developer (R).
    Type: Grant
    Filed: May 28, 2004
    Date of Patent: July 3, 2007
    Assignees: Proteus SA, Universite de Berne
    Inventors: Jean-Louis Reymond, Denis Wahler
  • Publication number: 20070099257
    Abstract: This invention has as its object a method for releasing a product by subjecting a compound of Formula (II?): R?7R?8(HX)C1-C2(YH)R?9R?10 to a chemical oxidation that cleaves the bond C1-C2 to obtain the product. In the compound of Formula (II?): R?7 to R?10, which are identical or different, correspond to a hydrogen atom, a substituted or unsubstituted alkyl group, or a substituted or unsubstituted functional group; X and Y, which are identical or different, are an oxygen atom, a sulfur atom, or an amine of Formula —NR11R12, wherein R11 is a hydrogen atom, an alkyl group, or a substituted or unsubstituted aryl group, and R12 is not a hydrogen atom. The invention also has as its object a method for releasing a product that comprises, before the chemical oxidation stage, a first step for preparing the compound of Formula (II?). The released product can be a volatile molecule or an active substance or else a specific product.
    Type: Application
    Filed: November 20, 2006
    Publication date: May 3, 2007
    Applicants: Proteus, Universite de Berne
    Inventors: Jean-Louis Reymond, Denis Wahler, Frabrizzio Badalassi, Hong-Khanh Nguyen
  • Publication number: 20050014212
    Abstract: This invention has as its object a method for detecting catalytic activity of a sample, characterized in that it comprises: the incubation of a substrate (S) with the sample that may have the catalytic activity that it is desired to detect, the addition of a reagent (X) that can react either with a chemical group of unconsumed substrate (S) or with a chemical group of product (P) that is formed after an incubation period with the sample, the addition of a developer (R) that can react with reagent (X), and the detection of the transformation of developer (R).
    Type: Application
    Filed: May 28, 2004
    Publication date: January 20, 2005
    Applicants: PROTEUS, UNIVERSITY OF BERNE
    Inventors: Jean-Louis Reymond, Denis Wahler
  • Publication number: 20050009098
    Abstract: This invention has as its object a process for generating the idiosyncratic catalytic imprint of a sample, characterized in that it comprises the following stages: the sample that is likely to have the catalytic activity is brought into contact with a group of substrates; the signals that are generated after said contact are captured in some way. Advantageously, after the signals are captured, a processing of the latter that consists of assigning to each signal a digital value constituting a component of a graphic display, for example a color display, of the idiosyncratic imprint is carried out.
    Type: Application
    Filed: May 10, 2004
    Publication date: January 13, 2005
    Applicant: PROTEUS
    Inventors: Jean-Louis Reymond, Denis Wahler