Patents by Inventor Denis Wirtz

Denis Wirtz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160256404
    Abstract: The invention generally relates to polymeric particles suitable for transporting bioactive agents across mucosal barriers. The invention also relates to methods of making and using those polymeric particles.
    Type: Application
    Filed: February 12, 2015
    Publication date: September 8, 2016
    Inventors: Justin Hanes, Michelle R. Dawson, Denis Wirtz, Jie Fu, Eric M. Krauland
  • Patent number: 9435738
    Abstract: A diagnostic device includes a microscope configured to obtain image data on a plurality of cells and a computing device. The computing device is configured to receive the image data, identify at least a portion of each of the plurality of cells based on the received image data, determine at least one of a value of a morphological parameter for each identified at least a portion of the plurality of cells or a relative organization among the identified at least a portion of the plurality of cells, and calculate statistics for the plurality of cells based on the at least one of the determined values of the morphological parameter or the determined relative organization, the statistics including information suitable for distinguishing metastatic cells from non-metastatic cells. The diagnostic device further includes an output device configured to output the statistics for diagnosis.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: September 6, 2016
    Assignees: The Johns Hopkins University, University of Florida
    Inventors: Denis Wirtz, Pei-Hsun Wu, Shyam B. Khatau, Wei-Chang Chen, Jude M. Phillip, Jr., Zev A. Binder, Yiider Tseng
  • Publication number: 20150093779
    Abstract: A diagnostic device includes a microscope configured to obtain image data on a plurality of cells and a computing device. The computing device is configured to receive the image data, identify at least a portion of each of the plurality of cells based on the received image data, determine at least one of a value of a morphological parameter for each identified at least a portion of the plurality of cells or a relative organization among the identified at least a portion of the plurality of cells, and calculate statistics for the plurality of cells based on the at least one of the determined values of the morphological parameter or the determined relative organization, the statistics including information suitable for distinguishing metastatic cells from non-metastatic cells. The diagnostic device further includes an output device configured to output the statistics for diagnosis.
    Type: Application
    Filed: December 4, 2014
    Publication date: April 2, 2015
    Applicants: The Johns Hopkins University, University of Florida
    Inventors: Denis Wirtz, Pei-Hsun Wu, Shyam B. Khatau, Wei-Chang Chen, Jude M. Phillip, JR., Zev A. Binder, Yiidar Tseng
  • Patent number: 8957034
    Abstract: The invention generally relates to polymeric particles suitable for transporting bioactive agents across mucosal barriers. The invention also relates to methods of making and using those polymeric particles.
    Type: Grant
    Filed: January 28, 2005
    Date of Patent: February 17, 2015
    Assignee: Johns Hopkins University
    Inventors: Justin Hanes, Michelle Rose Dawson, Denis Wirtz, Jie Fu, Eric Mark Krauland
  • Patent number: 8350564
    Abstract: A system and a method for determining the torque imposed on a filament, such as a single DNA strand or macromolecule, using a magnetic probe and an imaging device.
    Type: Grant
    Filed: March 9, 2010
    Date of Patent: January 8, 2013
    Assignee: The Johns Hopkins University
    Inventors: Alfredo A. Celedon, Sean X. Sun, Gregory Bowman, Denis Wirtz, Peter Searson
  • Publication number: 20100253328
    Abstract: A system and a method for determining the torque imposed on a filament, such as a single DNA strand or macromolecule, using a magnetic probe and an imaging device.
    Type: Application
    Filed: March 9, 2010
    Publication date: October 7, 2010
    Applicant: Johns Hopkins University
    Inventors: Alfredo A. Celedon, Sean X. Sun, Gregory Bowman, Denis Wirtz, Peter Searson
  • Publication number: 20080166414
    Abstract: The invention generally relates to polymeric particles suitable for transporting bioactive agents across mucosal barriers. The invention also relates to methods of making and using those polymeric particles.
    Type: Application
    Filed: January 28, 2005
    Publication date: July 10, 2008
    Applicant: Johns Hopkins University
    Inventors: Justin Hanes, Michelle Rose Dawson, Denis Wirtz, Jie Fu, Eric Mark Krauland
  • Publication number: 20070212681
    Abstract: Methods and compositions for the reliable detection of pathogens are presented. The invention uses cells as novel pathogen detection agents, exploiting pathogen-specific pathways and apoptosis.
    Type: Application
    Filed: August 30, 2005
    Publication date: September 13, 2007
    Inventors: Benjamin Shapiro, Pamela Abshire, Elisabeth Smela, Denis Wirtz
  • Publication number: 20040067599
    Abstract: A Repeated Classification Procedure (RCP) for the rapid separation, identification, classification, and quantitation of proteins in a mixture of proteins utilizes general-motif antibodies which typically bind to a plurality of proteins in a mixture which have a common motif or are homologs in some respect. By repeatedly using general-motif antibodies or using general-motif antibodies in conjunction with specific antibodies, a pattern of binding can be produced which uniquely identifies proteins of interest. By using immobilized general-motif antibodies to effect separation, the identification, classification, and quantitation of proteins in a sample can be use to characterize the protein synthesis pattern of disease states. Quantitation of protein in a sample can be determined based on the movement of very small beads with bound protein in a magnetic field, wherein larger quantities of bound protein causes the beads to travel relatively smaller distances or at relatively slower rates.
    Type: Application
    Filed: November 20, 2003
    Publication date: April 8, 2004
    Inventors: Joseph L. Katz, Denis Wirtz