Patents by Inventor Denise Barbut

Denise Barbut has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200262864
    Abstract: Described are deuterated forms of aminosterols, or a pharmaceutically acceptable salt thereof, wherein one or more hydrogen atoms at one or more positions selected from C1, C2, C3, C4, C5, C6, C7, C8, C9, C11, C12, C14, C15, C16, C17, C18, C19, C20, C21, C22, C23, C24, C25, C26, and C27, are replaced with deuterium.
    Type: Application
    Filed: February 19, 2020
    Publication date: August 20, 2020
    Applicant: Enterin, Inc.
    Inventors: Denise Barbut, Michael Zasloff, William A. Kinney, Stephen Jones, Scott Ashford, Anton Bieliauskas, Edward Hessler, Tom Fevig, Harold Karnes
  • Publication number: 20200155574
    Abstract: The present application relates generally to methods for treating, preventing and/or slowing the onset or progression of schizophrenia and/or a related symptom. The methods comprise administering at least one aminosterol or a pharmaceutically acceptable salt or derivative thereof to a subject in need.
    Type: Application
    Filed: August 2, 2019
    Publication date: May 21, 2020
    Applicant: Enterin, Inc.
    Inventors: Denise Barbut, Michael Zasloff
  • Publication number: 20200129528
    Abstract: The present application relates generally to compositions and methods for treating, preventing, and/or slowing the onset or progression of high blood pressure or low blood pressure and a variety of symptoms related thereto with aminosterols or pharmaceutically acceptable salts or derivatives thereof.
    Type: Application
    Filed: August 2, 2019
    Publication date: April 30, 2020
    Inventors: Denise Barbut, Michael Zasloff
  • Patent number: 10561527
    Abstract: Devices for cerebral and systemic cooling via a patient's nasopharyngeal cavity are described. Cooling assemblies include at least one elongate tubular member having first and second lumens, a source of liquid coolant, a gas source communicating with the first lumen, and a switch for alternately connecting the liquid coolant source to the second lumen. The first lumen transports a compressed gas and the second lumen transports a volatile liquid. The pressurized fluid may be a perfluorocarbon. The perfluorocarbon may be perfluorohexane, perfluoropentane, or 2-methyl-perfluoropentane. The gas may be air, oxygen, or a combination.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: February 18, 2020
    Assignee: BrainCool AB
    Inventors: Allan Rozenberg, Denise Barbut, John K Hoffman, Thomas H Shaffer
  • Publication number: 20200038415
    Abstract: The present application relates generally to compositions and methods for treating, preventing, and/or slowing the onset or progression of erectile dysfunction (ED) and a variety of symptoms related thereto with amino sterols or pharmaceutically acceptable salts or derivatives thereof.
    Type: Application
    Filed: August 2, 2019
    Publication date: February 6, 2020
    Applicant: Enterin, Inc.
    Inventors: Denise Barbut, Michael Zasloft
  • Publication number: 20200038417
    Abstract: This invention relates to methods of treating, preventing, and/or slowing the onset or progression of cognitive impairment and/or a cognitive impairment related symptom in a subject in need. The methods, which utilize a patient-specific “fixed dose” of an aminosterol, comprise administering a therapeutically effective dose of an aminosterol to a subject in need.
    Type: Application
    Filed: August 2, 2019
    Publication date: February 6, 2020
    Applicant: Enterin, Inc.
    Inventors: Denise Barbut, Michael Zasloff
  • Publication number: 20200038420
    Abstract: The present application relates generally to methods for treating, preventing, and/or slowing the onset or progression of depression and a variety of symptoms related thereto with aminosterols or pharmaceutically acceptable salts or derivatives thereof.
    Type: Application
    Filed: August 2, 2019
    Publication date: February 6, 2020
    Applicant: Enterin, Inc.
    Inventors: Denise Barbut, Michael Zasloff
  • Publication number: 20200038413
    Abstract: The present application relates generally to compositions and methods for treating and/or preventing Parkinson's disease and symptoms related thereto with with compositions comprising at least one aminosterol or a pharmaceutically acceptable salt or derivative thereof.
    Type: Application
    Filed: August 2, 2019
    Publication date: February 6, 2020
    Applicant: Enterin, Inc.
    Inventors: Denise Barbut, Michael Zasloff
  • Publication number: 20200038419
    Abstract: The present application relates generally to compositions and methods for treating, preventing, and/or slowing the onset or progression of multiple system atrophy (MSA) and a variety of symptoms related thereto with aminosterols or pharmaceutically acceptable salts or derivatives thereof.
    Type: Application
    Filed: August 2, 2019
    Publication date: February 6, 2020
    Applicant: Enterin, Inc.
    Inventors: Denise Barbut, Michael Zasloff
  • Publication number: 20200038414
    Abstract: This invention relates to methods of treating constipation and constipation-related symptoms in a subject in need. The methods, which utilize a patient-specific “fixed dose” of an aminosterol, comprise administering a therapeutically effective dose of an aminosterol to a subject in need.
    Type: Application
    Filed: August 2, 2019
    Publication date: February 6, 2020
    Applicant: Enterin, Inc.
    Inventors: Denise Barbut, Michael Zasloff
  • Publication number: 20200038412
    Abstract: The present application relates generally to compositions and methods for treating, preventing, and/or slowing the onset or progression of Alzheimer's disease (AD) and a variety of symptoms related thereto with amino sterols or pharmaceutically acceptable salts or derivatives thereof.
    Type: Application
    Filed: August 2, 2019
    Publication date: February 6, 2020
    Applicant: Enterin, Inc.
    Inventors: Denise Barbut, Michael Zasloff
  • Publication number: 20200038416
    Abstract: The present application relates generally to compositions and methods for treating, preventing, and/or slowing the onset or progression of cardiac conduction defects (CCDs) and a variety of symptoms related thereto with amino sterols or pharmaceutically acceptable salts or derivatives thereof.
    Type: Application
    Filed: August 2, 2019
    Publication date: February 6, 2020
    Applicant: Enterin, Inc.
    Inventors: Denise Barbut, Michael Zasloff
  • Publication number: 20200038418
    Abstract: The present application relates generally to compositions and methods for treating, preventing, and/or slowing the onset or progression of autism spectrum disorder (ASD) and a variety of symptoms related thereto with aminosterols or pharmaceutically acceptable salts or derivatives thereof.
    Type: Application
    Filed: August 2, 2019
    Publication date: February 6, 2020
    Applicant: Enterin, Inc.
    Inventors: Denise Barbut, Michael Zasloff
  • Publication number: 20190381071
    Abstract: This invention relates to methods of treating and/or preventing the progression and/or onset of age-related neurodegeneration. The invention also relates to methods of reversibly slowing the growth and/or aging of a subject, and/or extending the potential lifespan of the subject, comprising administration of the naturally occurring aminosterol MSI-1436, or derivatives or salts thereof. Also described are methods of treating, preventing or delaying the onset of age-related diseases or conditions comprising administration of Aminosterol 1436, or derivatives or salts thereof.
    Type: Application
    Filed: June 13, 2019
    Publication date: December 19, 2019
    Applicant: Enterin, Inc.
    Inventors: Michael Zasloff, Denise Barbut
  • Publication number: 20190298740
    Abstract: This application relates to methods of treating, preventing and/or slowing the onset or progression of hallucinations and/or related symptoms caused by a variety disorders, with aminosterols or pharmaceutically acceptable salts or derivatives thereof.
    Type: Application
    Filed: March 25, 2019
    Publication date: October 3, 2019
    Applicant: Enterin, Inc.
    Inventors: Denise Barbut, Michael Zasloff
  • Publication number: 20190127416
    Abstract: Provided herein are crystalline solid forms of squalamine phosphate designated as Form 1 and Form 2, compositions containing one or both forms, and methods of their preparation and of their use.
    Type: Application
    Filed: October 26, 2018
    Publication date: May 2, 2019
    Applicant: Enterin, Inc.
    Inventors: Denise Barbut, Michael Zasloff
  • Publication number: 20190091241
    Abstract: This invention relates to methods of treating or preventing a sleep disorder, sleep disturbance, or related symptom in a subject with aminosterols or pharmaceutically acceptable salts or derivatives thereof. In particular, the disclosed methods generally comprise administering an aminosterol to a subject in need, thereby stimulating an aminosterol-induced CNS response to treat and/or prevent a sleep disorder, sleep disturbance, or related symptom.
    Type: Application
    Filed: September 5, 2018
    Publication date: March 28, 2019
    Applicant: Enterin, Inc.
    Inventors: Denise Barbut, Michael Zasloff
  • Publication number: 20180344748
    Abstract: Described are methods of treating or preventing an inflammatory disease or condition caused by excessive expression, secretion, or concentration of alpha synuclein. The methods comprise administering compositions that reduce the effective concentration of alpha-synuclein present in the surrounding tissues. In addition, the invention encompasses methods of inhibiting alpha-synuclein interaction with CD11b, comprising administering an agent that binds to alpha-synuclein to prevent binding productively to the integrin CD11b, or administering an active agent that interacts with CD11b on an immune cell to prevent alpha-synuclein from directing chemotaxis of that cell. In addition, the invention discloses a method of identifying an individual with a condition amenable to treatment targeting alpha-synuclein CD11b interaction.
    Type: Application
    Filed: May 30, 2018
    Publication date: December 6, 2018
    Applicant: ENTERIN LABORATORIES, INC.
    Inventors: Denise Barbut, Ethan Stolzenberg, Michael Zasloff
  • Patent number: 9775741
    Abstract: Methods for cerebral cooling are described. Cooling assemblies include elongate tubular members, a reservoir containing a pressurized fluid, and a manifold connecting the reservoir and elongate tubular members. After insertion of the elongate tubular members into the patient's nostrils, a pressurized fluid is delivered onto a surface of the patient's nasal cavity through a plurality of ports in the elongate tubular members. The delivery of the fluid causes cooling by direct heat transfer through the nasopharynx and hematogenous cooling through the carotids and the Circle of Willis.
    Type: Grant
    Filed: April 30, 2014
    Date of Patent: October 3, 2017
    Assignee: BrainCool AB
    Inventors: Denise Barbut, Alan Rozenberg, John K Hoffman, Thomas H Shaffer
  • Publication number: 20170027745
    Abstract: Devices for cerebral and systemic cooling via a patient's nasopharyngeal cavity are described. Cooling assemblies include at least one elongate tubular member having first and second lumens, a source of liquid coolant, a gas source communicating with the first lumen, and a switch for alternately connecting the liquid coolant source to the second lumen. The first lumen transports a compressed gas and the second lumen transports a volatile liquid. The pressurized fluid may be a perflurocarbon. The perfluorocarbon may be perfluorohexane, perfluoropentane, or 2-methyl-perfluoropentane. The gas may be air, oxygen, or a combination.
    Type: Application
    Filed: June 2, 2016
    Publication date: February 2, 2017
    Inventors: Allan ROZENBERG, Denise BARBUT, John K. HOFFMAN, Thomas H. SHAFFER