Patents by Inventor Denise Blum

Denise Blum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2,3-Oxidosqualene-lanosterol cyclase inhibitors
    Patent number: 7335687
    Abstract: The present invention relates to aminocyclohexanol derivatives useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
    Type: Grant
    Filed: December 15, 2004
    Date of Patent: February 26, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jean Ackermann, Johannes Aebi, Denise Blum, Alexander Chucholowski, Henrietta Dehmlow, Hans-Peter Maerki, Olivier Morand, Rene Trussardi, Elisabeth von der Mark, Sabine Wallbaum, Thomas Weller
  • 2,3-Oxidosqualene-lanosterol cyclase inhibitors
    Publication number: 20050176766
    Abstract: The present invention relates to aminocyclohexanol derivatives useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
    Type: Application
    Filed: December 15, 2004
    Publication date: August 11, 2005
    Inventors: Jean Ackermann, Johannes Aebi, Denise Blum, Alexander Chucholowski, Henrietta Dehmlow, Hans-Peter Maerki, Olivier Morand, Rene Trussardi, Elisabeth von der Mark, Sabine Wallbaum, Thomas Weller
  • 2,3-oxidosqualene-lanosterol cyclase inhibitors
    Patent number: 6858651
    Abstract: The present invention relates to aminocyclohexanol derivatives useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
    Type: Grant
    Filed: August 9, 2001
    Date of Patent: February 22, 2005
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jean Ackermann, Johannes Aebi, Denise Blum, Alexander Chucholowski, Henrietta Dehmlow, Hans-Peter Maerki, Olivier Morand, Rene Trussardi, Elisabeth von der Mark, Sabine Wallbaum, Thomas Weller
  • Pyrrolidine derivatives
    Patent number: 6541638
    Abstract: The present invention relates to pyrrolidine derivatives and dimeric forms and/or pharmaceutically acceptable esters, and/or salts thereof. The compounds are useful as inhibitors of metalloproteases, e.g. zinc proteases, particularly zinc hydrolases, and which are effective in treating disease states are associated with vasoconstriction of increasing occurrences.
    Type: Grant
    Filed: July 17, 2001
    Date of Patent: April 1, 2003
    Assignee: Hoffman-La Roche Inc.
    Inventors: Johannes Aebi, Denise Blum, Daniel Bur, Alexander Chucholowski, Henrietta Dehmlow, Eric Argirios Kitas, Bernd Michael Loeffler, Ulrike Obst, Sabine Wallbaum
  • Pyrrolidine derivatives
    Publication number: 20020049243
    Abstract: The present invention relates to pyrrolidine derivatives and dimeric forms and/or pharmaceutically acceptable esters, and/or salts thereof. The compounds are useful as inhibitors of metalloproteases, e.g. zinc proteases, particularly zinc hydrolases, and which are effective in treating disease states are associated with vasoconstriction of increasing occurrences.
    Type: Application
    Filed: July 17, 2001
    Publication date: April 25, 2002
    Inventors: Johannes Aebi, Denise Blum, Daniel Bur, Alexander Chucholowski, Henrietta Dehmlow, Eric Argirios Kitas, Bernd Michael Loeffler, Ulrike Obst, Sabine Wallbaum
  • 2,3-oxidosqualene-lanosterol cyclase inhibitors
    Publication number: 20020045777
    Abstract: The present invention relates to aminocyclohexanol derivatives useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
    Type: Application
    Filed: August 9, 2001
    Publication date: April 18, 2002
    Inventors: Jean Ackermann, Johannes Aebi, Denise Blum, Alexander Chucholowski, Henrietta Dehmlow, Hans-Peter Maerki, Olivier Morand, Rene Trussardi, Elisabeth von der Mark, Sabine Wallbaum, Thomas Weller