Patents by Inventor Denise Demarais
Denise Demarais has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20060265014Abstract: Methods and apparatus are provided for bilateral renal neuromodulation, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.Type: ApplicationFiled: March 6, 2006Publication date: November 23, 2006Applicant: Ardian, Inc.Inventors: Denise Demarais, Hanson Gifford, Mark Deem, Douglas Sutton, Howard Levin, Mark Gelfand
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Publication number: 20060235474Abstract: Methods and apparatus are provided for multi-vessel neuromodulation, e.g., via a pulsed electric field. Such multi-vessel neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, the multi-vessel neuromodulation is applied to neural fibers that contribute to renal function. Such multi-vessel neuromodulation optionally may be performed bilaterally.Type: ApplicationFiled: June 12, 2006Publication date: October 19, 2006Applicant: Ardian, Inc.Inventor: Denise Demarais
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Publication number: 20060212078Abstract: Methods and apparatus are provided for treating congestive heart failure, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.Type: ApplicationFiled: March 6, 2006Publication date: September 21, 2006Applicant: Ardian, Inc.Inventors: Denise Demarais, Hanson Gifford, Mark Deem, Douglas Sutton, Howard Levin, Mark Gelfand
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Publication number: 20060212076Abstract: Methods and apparatus are provided for treating end-stage renal disease, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.Type: ApplicationFiled: March 6, 2006Publication date: September 21, 2006Applicant: Ardian, Inc.Inventors: Denise Demarais, Hanson Gifford, Mark Deem, Douglas Sutton, Howard Levin, Mark Gelfand
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Publication number: 20060206150Abstract: Methods and apparatus are provided for treating acute myocardial infarction, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.Type: ApplicationFiled: March 6, 2006Publication date: September 14, 2006Applicant: Ardian, Inc.Inventors: Denise Demarais, Hanson Gifford, Mark Deem, Douglas Sutton, Howard Levin, Mark Gelfand
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Publication number: 20060142801Abstract: Methods and apparatus are provided for intravascularly-induced neuromodulation using a pulsed electric field, e.g., to effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, changes in cytokine upregulation, etc., in target neural fibers. In some embodiments, the intravascular PEF system comprises a catheter having a pair of bipolar electrodes for delivering the PEF, with a first electrode positioned on a first side of an impedance-altering element and a second electrode positioned on an opposing side of the impedance-altering element. A length of the electrodes, as well as a separation distance between the first and second electrodes, may be specified such that, with the impedance-altering element deployed in a manner that locally increases impedance within a patient's vessel, e.g.Type: ApplicationFiled: November 4, 2005Publication date: June 29, 2006Applicant: Ardian, Inc.Inventors: Denise Demarais, Nicolas Zadno, Benjamin Clark, Erik Thai
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Publication number: 20060041277Abstract: Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for extravascular delivery of pulsed electric fields to achieve such neuromodulation.Type: ApplicationFiled: July 25, 2005Publication date: February 23, 2006Inventors: Mark Deem, Denise Demarais, Douglas Sutton, Hanson Gifford, Howard Levin, Mark Gelfand, Benjamin Clark
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Publication number: 20050288764Abstract: Prosthesis delivery devices and methods are provided that enable precise control of prosthesis position during deployment. The prosthesis delivery devices may carry multiple prostheses and include deployment mechanisms for delivery of a selectable number of prostheses. Control mechanisms are provided in the prosthesis delivery devices that control either or both of the axial and rotational positions of the prostheses during deployment. This enables the deployment of multiple prostheses at a target site with precision and predictability, eliminating excessive spacing or overlap between prostheses. In particular embodiments, the prostheses of the invention are deployed in stenotic lesions in coronary or peripheral arteries, or in other vascular locations.Type: ApplicationFiled: September 30, 2004Publication date: December 29, 2005Applicant: Xtent, Inc.Inventors: David Snow, Joseph Karratt, Jeffry Grainger, Denise Demarais
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Publication number: 20050288730Abstract: Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.Type: ApplicationFiled: May 13, 2005Publication date: December 29, 2005Inventors: Mark Deem, Hanson Gifford, Denise Demarais, Douglas Sutton, Erik Thai, Mark Gelfand, Howard Levin
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Publication number: 20050261672Abstract: Methods and apparatus are provided for selective denervation of conduction pathways in the heart for the treatment of dysrhythmias, including one or more ablation or electroporation catheters having electrodes for stimulating, targeting, and ablating fat pad tissue and other cardiac tissue to selectively denervate heart tissue.Type: ApplicationFiled: May 18, 2005Publication date: November 24, 2005Inventors: Mark Deem, Hanson Gifford, Denise Demarais
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Publication number: 20050228504Abstract: Methods and devices for simulating a gastric bypass and reducing the volume of the stomach involve placing a tubular liner along the lesser curve of the stomach cavity. Also, methods and devices for slowing gastric emptying involve placing valves within the stomach cavity near the gastrointestinal junction and/or the pylorus. These methods and devices may prevent a patient from drinking and eating large volumes at one time and from eating slowly all day.Type: ApplicationFiled: March 25, 2005Publication date: October 13, 2005Inventor: Denise Demarais
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Patent number: 6945977Abstract: Thrombectomy and other treatments are achieved using a catheter having a positioning cage and a macerator within the positioning cage. The catheter is introduced to a target body lumen, typically a blood vessel, and a positioning cage deployed at a treatment site. The macerator is then operated to disrupt thrombus, clot, or other occlusive materials at the treatment site, and the catheter is used to collect and remove the disruptive materials from the body lumen. In particular examples, the macerator may be radially expansible and optionally rotated and/or axially translated within the positioning cage to effect disruption of the occlusive material.Type: GrantFiled: October 6, 2003Date of Patent: September 20, 2005Assignee: Bacchus Vascular, Inc.Inventors: Denise Demarais, Michael A. Evans, Stephen A. Leeflang, Christian S. Eversull
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Publication number: 20050192599Abstract: Methods and devices for providing a minimally-invasive placement of a mechanical structure for reducing the volume of a hollow body organ. Anchors may be secured within the hollow body organ and then cinched together using a tensioning member to form a stricture within the hollow body organ. In another embodiment a tensioning member may be threaded along the hollow body organ and then cinched to reduce the volume. The strictures may be placed anywhere within the hollow body organ, and more than one stricture may be formed within the hollow body organ.Type: ApplicationFiled: February 11, 2005Publication date: September 1, 2005Inventor: Denise Demarais
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Publication number: 20050192601Abstract: Methods and devices for providing a minimally-invasive placement of a mechanical structure for reducing the volume of a hollow body organ. Intragastric bands may be secured within the hollow body organ and then reduced in diameter to form a stricture within the hollow body organ. The strictures may be placed anywhere within the hollow body organ, and more than one stricture may be formed within the hollow body organ.Type: ApplicationFiled: February 25, 2005Publication date: September 1, 2005Inventor: Denise Demarais
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Patent number: 6929633Abstract: Clot disruption and dissolution are achieved using a catheter having the ability to infuse a thrombolytic agent, agitate the clot and agent, and aspirate broken-up clot from the blood vessel. A flow resistor in the catheter provides for infusion and/or aspiration to be concentrated primarily at a clot treatment area in a blood vessel while also providing optional infusion and/or aspiration distal to the treatment area. In some embodiments, infusion, aspiration and guidewire passage occur through a common lumen. The thrombolytic agent, such as tPA, streptokinase, or urokinase, is directly released into the clot at the point where the agitator is engaging the clot. In this way, the thrombolytic activity of the agent is enhanced and the dissolution of the clot is improved.Type: GrantFiled: October 21, 2002Date of Patent: August 16, 2005Assignee: Bacchus Vascular, Inc.Inventors: Michael A. Evans, Denise Demarais, Dino De Cicco, Kelvin Ning, Alexander Khairkhahan, Tyler Jon Strang, Jody Maria Cimbalo, Stephen Leeflang
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Publication number: 20040098033Abstract: An apparatus includes a jet housing including an inlet and an outlet, and a nozzle within the jet housing for injecting fluid towards the outlet. A filter element is disposed on the inlet, the filter element including openings for preventing particulate larger than a predetermined size from entering the inlet. The jet housing is positioned within a blood vessel, and fluid is injected from the nozzle towards the outlet to create a vacuum at the inlet, thereby causing fluid downstream of the outlet to flow retrograde through the vessel around the jet housing into the inlet. The filter element prevents particulate from entering the inlet, thereby effectively capturing the particulate, which may be aspirated. Alternatively, a filter element is used to filter particulate during a procedure. The filter element everts from a tubular to an everted configuration for capturing particulate.Type: ApplicationFiled: October 1, 2003Publication date: May 20, 2004Applicant: BACCHUS VASCULAR, INC.Inventors: Stephen A. Leeflang, Denise DeMarais, Michael A. Evans
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Publication number: 20040082962Abstract: Thrombectomy and other treatments are achieved using a catheter having a positioning cage and a macerator within the positioning cage. The catheter is introduced to a target body lumen, typically a blood vessel, and a positioning cage deployed at a treatment site. The macerator is then operated to disrupt thrombus, clot, or other occlusive materials at the treatment site, and the catheter is used to collect and remove the disruptive materials from the body lumen. In particular examples, the macerator may be radially expansible and optionally rotated and/or axially translated within the positioning cage to effect disruption of the occlusive material.Type: ApplicationFiled: October 6, 2003Publication date: April 29, 2004Applicant: BACCHUS VASCULAR, INC.Inventors: Denise Demarais, Michael A. Evans, Stephen A. Leeflang, Christian S. Eversull
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Publication number: 20040006306Abstract: An apparatus for treating an occlusive region of a blood vessel includes a catheter including a first lumen extending from an end port to a first side port, and a second lumen extending from a proximal end of the catheter to a second side port. A balloon is mounted on the catheter between the first and second side ports. During use, a guidewire is placed into an occlusive region, and the guidewire is backloaded through the first and second lumens. The catheter is advanced over the guidewire, and the balloon is expanded to isolate the occlusive region. The guidewire is removed, and an agitator is advanced through the second lumen. After the agitator is agitated to dislodge occlusive material from the occlusive region, the agitator is removed, and the loose occlusive material is aspirated via the second side port.Type: ApplicationFiled: May 13, 2003Publication date: January 8, 2004Applicant: BACCHUS VASCULAR INC.Inventors: Michael A. Evans, Denise Demarais, Alexander Khairkhahan, Dino Decicco
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Patent number: 6660014Abstract: Thrombectomy and other treatments are achieved using a catheter having a positioning cage and a macerator within the positioning cage. The catheter is introduced to a target body lumen, typically a blood vessel, and a positioning cage deployed at a treatment site. The macerator is then operated to disrupt thrombus, clot, or other occlusive materials at the treatment site, and the catheter is used to collect and remove the disruptive materials from the body lumen. In particular examples, the macerator may be radially expansible and optionally rotated and/or axially translated within the positioning cage to effect disruption of the occlusive material.Type: GrantFiled: June 3, 2002Date of Patent: December 9, 2003Assignee: Bacchus Vascular, Inc.Inventors: Denise Demarais, Michael A. Evans, Stephen A. Leeflang, Christian S. Eversull
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Patent number: 6635070Abstract: An apparatus includes a jet housing including an inlet and an outlet, and a nozzle within the jet housing for injecting fluid towards the outlet. A filter element is disposed on the inlet, the filter element including openings for preventing particulate larger than a predetermined size from entering the inlet. The jet housing is positioned within a blood vessel, and fluid is injected from the nozzle towards the outlet to create a vacuum at the inlet, thereby causing fluid downstream of the outlet to flow retrograde through the vessel around the jet housing into the inlet. The filter element prevents particulate from entering the inlet, thereby effectively capturing the particulate, which may be aspirated. Alternatively, a filter element is used to filter particulate during a procedure. The filter element everts from a tubular to an everted configuration for capturing particulate.Type: GrantFiled: May 21, 2001Date of Patent: October 21, 2003Assignee: Bacchus Vascular, Inc.Inventors: Stephen Leeflang, Denise DeMarais, Michael Evans