Abstract: A method for inhibiting rejection by a recipient animal of a transplanted tissue, said method comprising modifying, eliminating, or masking an antigen which, when present on the surface of a cell of said tissue, is capable of causing a T-lymphocyte-mediated response in said animal, to inhibit antigen-mediated interaction between said cell and a T-lymphocyte of said animal without causing lysis of said cell.

Abstract: Described are methods for determining the predisposition of a mammal for developing an autoimmune disease that is characterized by defective presentation of self antigens on the surface of antigen presenting cells. The methods involve identifying defects in the processing, transport, or presentation of self peptides by MHC class I molecules. Defects in or deletions of components of these processes result in decreased levels of normal MHC class I expression on the surface of mammalian antigen presenting cells. Identification of these defects or deletions, or observation of such a decreased level of MHC class I expression, is indicative of a predisposition for an individual developing an autoimmune disease characterized by improper self antigen presentation.

Abstract: A method for inhibiting rejection by a recipient animal of a transplanted tissue, said method comprising modifying, eliminating, or masking an antigen which, when present on the surface of a cell of said tissue, is capable of causing a T-lymphocyte-mediated response in said animal, to inhibit antigen-mediated interaction between said cell and a T-lymphocyte of said animal without causing lysis of said cell.

Abstract: Disclosed is a method for treating insulin resistance in a patient which involves isolating a skeletal muscle cell from an insulin-sensitive donor and transplanting the skeletal muscle cell into the skeletal muscle tissue of the insulin-resistant patient. The transplanted cell may be a muscle precursor cell, e.g., a myoblast or it may be derived from whole skeletal muscle tissue.