Patents by Inventor Denise Gavin

Denise Gavin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Temperature-sensitive regulation of viral vector production
    Patent number: 6627617
    Abstract: The present invention provides temperature-sensitive (ts) adeno-associated virus (AAV) Rep78 and Rep68 proteins. In preferred embodiments, the ts AAV Rep78 and Rep68 proteins have missense mutations at amino acid positions 40, 42 and 44 that confer a temperature-sensitive phenotype. Also provided are nucleotide sequences and vectors encoding the inventive ts Rep proteins. In preferred embodiments, a hybrid adenovirus vector is provided that stably comprises a nucleotide sequence encoding a ts AAV Rep protein according to the invention. The present invention also provides methods of packaging AAV vectors and methods of ex vivo gene delivery using the ts Rep proteins of the invention. Further provided are cells containing the ts AAV Rep proteins, preferably stably integrated into the genome of the cell.
    Type: Grant
    Filed: September 29, 2000
    Date of Patent: September 30, 2003
    Assignee: University of North Carolina at Chapel Hill
    Inventors: Richard Jude Samulski, Denise Gavin, Nicholas Muzyczka, Corinne Abernathy, Daniel Pereira