Patents by Inventor Denise John

Denise John has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA)
    Patent number: 11932854
    Abstract: The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity, and/or modulate a gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against target gene expression.
    Type: Grant
    Filed: October 25, 2021
    Date of Patent: March 19, 2024
    Assignee: Sirna Therapeutics, Inc.
    Inventors: Mark Cancilla, James John Cunningham, William Michael Flanagan, Henry J. Haringsma, Denise M. Kenski, Matthew G. Stanton, Steven M. Stirdivant, Aarron T. Willingham
  • Drill bit
    Patent number: 9869131
    Abstract: A drill bit comprises at least one blade, comprising a plurality of cutting elements in the form of polycrystalline diamond cutters disposed on a leading edge of the blade, at least one diamond impregnated cutting region, disposed behind the leading edge of the blade, and wherein at least one of the cutters disposed on the leading, edge is an off-tip cutting element, arranged so that it does not engage with the formation during drilling until bit wear has taken place.
    Type: Grant
    Filed: January 8, 2014
    Date of Patent: January 16, 2018
    Assignee: NOV Downhole Eurasia Limited
    Inventors: Stephen Williams, Denise John, Ryan Graham
  • Drill Bit
    Publication number: 20150345228
    Abstract: A drill bit comprises at least one blade, comprising a plurality of cutting elements in the form of polycrystalline diamond cutters disposed on a leading edge of the blade, at least one diamond impregnated cutting region, disposed behind the leading edge of the blade, and wherein at least one of the cutters disposed on the leading, edge is an off-tip cutting element, arranged so that it does not engage with the formation during drilling until bit wear has taken place.
    Type: Application
    Filed: January 8, 2014
    Publication date: December 3, 2015
    Applicant: NOV DOWNHOLE EURASIA LIMITED
    Inventors: Stephen Williams, Denise John, Ryan Graham