Patents by Inventor Denise KOTTWITZ

Denise KOTTWITZ has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MULTI-ANALYTE DIAGNOSTIC AND PROGNOSTIC ASSAYS FOR COLORECTAL CANCER AND USES THEREOF
    Publication number: 20260132469
    Abstract: Provided herein are methods, assays and kits for detecting methylated genomic DNA and one or more protein biomarkers in one or more biological samples. In some aspects, the disclosure provides methods, assays and kits for detecting or prognosing a proliferative disease, such as colorectal cancer, in a subject based on the presence of methylated genomic DNA and one or more protein biomarkers in one or more biological samples.
    Type: Application
    Filed: October 3, 2023
    Publication date: May 14, 2026
    Inventors: Andrew A. LUKOWIAK, Stephani D. HERNANDEZ, Denise KOTTWITZ, Jörn LEWIN, Uwe STAUB
  • METHODS FOR DETECTING CPG METHYLATION OF TUMOR-DERIVED DNA IN BLOOD SAMPLES
    Publication number: 20250333796
    Abstract: The present invention relates to the field of pharmacogenomics and in particular to detecting the presence or absence of methylated ANKRD13B and/or FOXF2 DNA derived from a tumor in blood or blood-derived samples or in other body fluids that contain DNA released from a tumor. This detection is useful for a minimally invasive diagnosis of cancers and the invention provides methods and oligonucleotides suitable for this purpose.
    Type: Application
    Filed: November 20, 2024
    Publication date: October 30, 2025
    Inventors: Jörn LEWIN, Denise KOTTWITZ, Selina ESCHE
  • IMPROVED METHODS FOR DETECTING COLORECTAL CANCER
    Publication number: 20250129427
    Abstract: The present invention relates to the field of pharmacogenomics and in particular to detecting the presence or absence of methylated ANKRD13B and/or SEPTIN9 DNA derived from a tumor in blood or blood-derived samples or in other body fluids that contain DNA released from a tumor. This detection is useful for a minimally or non-invasive as well as early and reliable diagnosis of colorectal cancer. The invention provides methods and oligonucleotides suitable for this purpose.
    Type: Application
    Filed: August 8, 2023
    Publication date: April 24, 2025
    Applicant: New Day Diagnostics LLC
    Inventors: Denise KOTTWITZ, Oliver HASINGER, Preeti RATHI, Thomas KÖNIG, Gunter WEISS, Anne SCHLEGEL, Jörn LEWIN
  • Methods for detecting CpG methylation and for diagnosing cancer
    Patent number: 12054786
    Abstract: The present invention relates to the field of pharmacogenomics and in particular to detecting the presence or absence of hypermethylated DNA. The detection of CpG methylation in marker DNA is useful for the diagnosis of cancers and the invention provides improved methods for this purpose. These improved methods allow in particular for a more sensitive detection of methylated marker DNA with high backgrounds of unmethylated marker DNA.
    Type: Grant
    Filed: April 26, 2022
    Date of Patent: August 6, 2024
    Assignee: New Day Diagnostics, LLC
    Inventors: Denise Kottwitz, Jorn Lewin, Anne Schlegel, Reimo Tetzner
  • METHODS FOR DETECTING LIVER CANCER
    Publication number: 20230287509
    Abstract: The present invention relates to the field of pharmacogenomics and in particular to detecting the presence or absence of methylated genomic DNA derived from liver cancer cells in biological samples such as body fluids that contain circulating DNA from the cancer cells. This detection is useful for an early and reliable diagnosis of liver cancer and the invention provides methods and oligonucleotides suitable for this purpose.
    Type: Application
    Filed: July 21, 2021
    Publication date: September 14, 2023
    Inventors: Jörn LEWIN, Denise KOTTWITZ
  • METHODS FOR DETECTING COLORECTAL CANCER
    Publication number: 20220403473
    Abstract: The present invention relates to the field of pharmacogenomics and in particular to detecting the presence or absence of methylated genomic DNA derived from colorectal cancer cells in biological samples such as body fluids that contain circulating DNA from the cancer cells. This detection is useful for an early and reliable diagnosis of colorectal cancer and the invention provides methods and oligonucleotides suitable for this purpose.
    Type: Application
    Filed: December 16, 2020
    Publication date: December 22, 2022
    Inventors: Jörn LEWIN, Denise KOTTWITZ
  • METHODS FOR DETECTING CpG METHYLATION AND FOR DIAGNOSING CANCER
    Publication number: 20220372579
    Abstract: The present invention relates to the field of pharmacogenomics and in particular to detecting the presence or absence of hypermethylated DNA. The detection of CpG methylation in marker DNA is useful for the diagnosis of cancers and the invention provides improved methods for this purpose. These improved methods allow in particular for a more sensitive detection of methylated marker DNA with high backgrounds of unmethylated marker DNA.
    Type: Application
    Filed: April 26, 2022
    Publication date: November 24, 2022
    Inventors: Denise KOTTWITZ, Jörn LEWIN, Anne SCHLEGEL, Reimo TETZNER
  • Methods for detecting CpG methylation and for diagnosing cancer
    Patent number: 11345966
    Abstract: The present invention relates to the field of pharmacogenomics and in particular to detecting the presence or absence of hypermethylated DNA. The detection of CpG methylation in marker DNA is useful for the diagnosis of cancers and the invention provides improved methods for this purpose. These improved methods allow in particular for a more sensitive detection of methylated marker DNA with high backgrounds of unmethylated marker DNA.
    Type: Grant
    Filed: March 8, 2018
    Date of Patent: May 31, 2022
    Assignee: EPIGENOMICS AG
    Inventors: Denise Kottwitz, Jörn Lewin, Anne Schlegel, Reimo Tetzner
  • METHODS FOR DETECTING HEAD AND NECK CANCER
    Publication number: 20200299779
    Abstract: The present invention relates to the field of pharmacogenomics and in particular to detecting the presence or absence of methylated genomic DNA derived from head and neck cancer cells in biological samples such as body fluids that contain circulating DNA from the cancer cells. This detection is useful for an early and reliable diagnosis of head and neck cancer and the invention provides methods and oligonucleotides suitable for this purpose.
    Type: Application
    Filed: February 12, 2020
    Publication date: September 24, 2020
    Inventors: Jörn LEWIN, Denise KOTTWITZ
  • METHODS FOR DETECTING CPG METHYLATION OF TUMOR-DERIVED DNA IN BLOOD SAMPLES
    Publication number: 20190032148
    Abstract: The present invention relates to the field of pharmacogenomics and in particular to detecting the presence or absence of methylated ANKRD13B and/or FOXF2 DNA derived from a tumor in blood or blood-derived samples or in other body fluids that contain DNA released from a tumor. This detection is useful for a minimally invasive diagnosis of cancers and the invention provides methods and oligonucleotides suitable for this purpose.
    Type: Application
    Filed: January 27, 2017
    Publication date: January 31, 2019
    Applicant: EPIGENOMICS AG
    Inventors: Jörn LEWIN, Denise KOTTWITZ, Selina ESCHE
  • METHODS FOR DETECTING CpG METHYLATION AND FOR DIAGNOSING CANCER
    Publication number: 20180202006
    Abstract: The present invention relates to the field of pharmacogenomics and in particular to detecting the presence or absence of hypermethylated DNA. The detection of CpG methylation in marker DNA is useful for the diagnosis of cancers and the invention provides improved methods for this purpose. These improved methods allow in particular for a more sensitive detection of methylated marker DNA with high backgrounds of unmethylated marker DNA.
    Type: Application
    Filed: March 8, 2018
    Publication date: July 19, 2018
    Inventors: Denise KOTTWITZ, Jörn LEWIN, Anne SCHLEGEL, Reimo TETZNER
  • Methods for detecting CpG methylation and for diagnosing cancer
    Patent number: 9957575
    Abstract: The present invention relates to the field of pharmacogenomics and in particular to detecting the presence or absence of hypermethylated DNA. The detection of CpG methylation in marker DNA is useful for the diagnosis of cancers and the invention provides improved methods for this purpose. These improved methods allow in particular for a more sensitive detection of methylated marker DNA with high backgrounds of unmethylated marker DNA.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: May 1, 2018
    Assignee: EPIGENOMICS AG
    Inventors: Denise Kottwitz, Jörn Lewin, Anne Schlegel, Reimo Tetzner
  • METHODS FOR DETECTING CpG METHYLATION AND FOR DIAGNOSING CANCER
    Publication number: 20170233820
    Abstract: The present invention relates to the field of pharmacogenomics and in particular to detecting the presence or absence of hypermethylated DNA. The detection of CpG methylation in marker DNA is useful for the diagnosis of cancers and the invention provides improved methods for this purpose. These improved methods allow in particular for a more sensitive detection of methylated marker DNA with high backgrounds of unmethylated marker DNA.
    Type: Application
    Filed: February 17, 2017
    Publication date: August 17, 2017
    Inventors: Denise KOTTWITZ, Jörn LEWIN, Anne SCHLEGEL, Reimo TETZNER