Patents by Inventor Denise Maxine Hoekstra
Denise Maxine Hoekstra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9938571Abstract: Manufacturing methods and compositions are described for production of self-contained microfluidic cartridge devices with on-board reagents for molecular biological testing. Sensitive reagents are stored in dry form without lyophilization or freezing, and reconstituted at the point of use with either a biological sample or a sample eluate at the point of use. Manufacturing methods include sheet and roll fabrication processes where the reagents are printed in place and sealed within individual microfluidic cartridges before gel vitrification.Type: GrantFiled: November 26, 2014Date of Patent: April 10, 2018Assignee: Micronics, Inc.Inventors: C. Frederick Battrell, Denise Maxine Hoekstra, Joan Haab, John R. Williford, Sabrina N. Gunderson, Elizabeth R. Leber, Isaac Sprague
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Patent number: 9468894Abstract: Disclosed herein is a device comprising a pair of bellows pumps configured for efficient mixing at a microfluidic scale. By moving a fluid sample and particles in suspension through an aperture between the paired bellows pump mixing chambers, molecular collisions leading to binding between the particles and ligands in the sample are enhanced. Such devices provide an alternative for mixing that does not use a vent and can be used with a variety of particles in suspension such as magnetic beads to capture or purify useful cells and molecules.Type: GrantFiled: May 2, 2011Date of Patent: October 18, 2016Assignee: Micronics, Inc.Inventors: John Clemmens, C. Frederick Battrell, John Gerdes, Denise Maxine Hoekstra
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Publication number: 20150158026Abstract: Microfluidic methods and devices for heterogeneous binding and agglutination assays are disclosed, with improvements relating to mixing and to reagent and sample manipulation in systems designed for safe handling of clinical test samples.Type: ApplicationFiled: January 30, 2015Publication date: June 11, 2015Inventors: C. Frederick Battrell, John Gerdes, Stephen Mordue, Jason Capodanno, Denise Maxine Hoekstra, John R. Williford, John Clemmens
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Publication number: 20150152481Abstract: Manufacturing methods and compositions are described for production of self-contained microfluidic cartridge devices with on-board reagents for molecular biological testing. Sensitive reagents are stored in dry form without lyophilization or freezing, and reconstituted at the point of use with either a biological sample or a sample eluate at the point of use. Manufacturing methods include sheet and roll fabrication processes where the reagents are printed in place and sealed within individual microfluidic cartridges before gel vitrification.Type: ApplicationFiled: November 26, 2014Publication date: June 4, 2015Inventors: C. Frederick Battrell, Denise Maxine Hoekstra, Joan Haab, John R. Williford, Sabrina N. Gates, Elizabeth R. Leber, Isaac Sprague
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Patent number: 8921085Abstract: Manufacturing methods and compositions are described for production of self-contained microfluidic cartridge devices with on-board reagents for molecular biological testing. Sensitive reagents are stored in dry form without lyophilization or freezing, and reconstituted at the point of use with either a biological sample or a sample eluate at the point of use. Manufacturing methods include sheet and roll fabrication processes where the reagents are printed in place and sealed within individual microfluidic cartridges before gel vitrification.Type: GrantFiled: December 12, 2011Date of Patent: December 30, 2014Assignee: Micronics, Inc.Inventors: C. Frederick Battrell, Denise Maxine Hoekstra, Joan Haab, John R. Williford, Sabrina N. Gates, Elizabeth R. Leber, Isaac Sprague
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Patent number: 8835146Abstract: Formulations for dry storage of PCR reagents are described. These formulations find use in manufacture of self-contained microfluidic card devices for PCR clinical testing in which the reagents are reconstituted at the point of testing. In these cards, TAQ polymerase is stored “on-board” in vitrified dry form without lyophilization or freezing, and is reconstituted by either the sample or a sample eluate during the assay.Type: GrantFiled: December 12, 2011Date of Patent: September 16, 2014Assignee: Micronics, Inc.Inventors: C. Frederick Battrell, Denise Maxine Hoekstra, Joan Haab, John R. Williford
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Patent number: 8772017Abstract: Integrated microfluidic cartridges for nucleic acid extraction, amplification, and detection from clinical samples are disclosed. The devices are single-entry, sanitary, and disposable. The devices enable simplex or multiplex nucleic acid target detection, as for example: assay panels for multiple infectious agents, or assay panels for cancerous cell types. Methods for use of microfluidic cartridges in a fully automated, pneumatically controlled apparatus are also disclosed.Type: GrantFiled: June 8, 2012Date of Patent: July 8, 2014Assignee: Micronics, Inc.Inventors: C. Frederick Battrell, John Gerdes, John R. Williford, Denise Maxine Hoekstra, Wayne L. Breidford, Stephen Mordue, John Clemmens, Melud Nabavi, Mark Kokoris
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Publication number: 20120329142Abstract: Integrated microfluidic cartridges for nucleic acid extraction, amplification, and detection from clinical samples are disclosed. The devices are single-entry, sanitary, and disposable. The devices enable simplex or multiplex nucleic acid target detection, as for example: assay panels for multiple infectious agents, or assay panels for cancerous cell types. Methods for use of microfluidic cartridges in a fully automated, pneumatically controlled apparatus are also disclosed.Type: ApplicationFiled: June 8, 2012Publication date: December 27, 2012Applicant: MICRONICS, INC.Inventors: C. Frederick BATTRELL, John GERDES, John R. WILLIFORD, Denise Maxine HOEKSTRA, Wayne L. BREIDFORD, Stephen MORDUE, John CLEMMENS, Melud NABAVI, Mark KOKORIS
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Patent number: 8222023Abstract: Integrated microfluidic cartridges for nucleic acid extraction, amplification, and detection from clinical samples are disclosed. The devices are single-entry, sanitary, and disposable. The devices enable simplex or multiplex nucleic acid target detection, as for example: assay panels for multiple infectious agents, or assay panels for cancerous cell types. Methods for use of microfluidic cartridges in a fully automated, pneumatically controlled apparatus are also disclosed.Type: GrantFiled: September 10, 2008Date of Patent: July 17, 2012Assignee: Micronics, Inc.Inventors: C. Frederick Battrell, John Gerdes, John R. Williford, Denise Maxine Hoekstra, Wayne L. Breidford, Stephen Mordue, John Clemmens, Melud Nabavi, Mark Kokoris
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Publication number: 20120164627Abstract: Microfluidic methods and devices for heterogeneous binding and agglutination assays are disclosed, with improvements relating to mixing and to reagent and sample manipulation in systems designed for safe handling of clinical test samples.Type: ApplicationFiled: January 3, 2012Publication date: June 28, 2012Applicant: Micronics, Inc.Inventors: C. Frederick Battrell, John Gerdes, Stephen Mordue, Jason Capodanno, Denise Maxine Hoekstra, John R. Williford, John Clemmens
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Publication number: 20120156750Abstract: Manufacturing methods and compositions are described for production of self-contained microfluidic cartridge devices with on-board reagents for molecular biological testing. Sensitive reagents are stored in dry form without lyophilization or freezing, and reconstituted at the point of use with either a biological sample or a sample eluate at the point of use. Manufacturing methods include sheet and roll fabrication processes where the reagents are printed in place and sealed within individual microfluidic cartridges before gel vitrification.Type: ApplicationFiled: December 12, 2011Publication date: June 21, 2012Applicant: Micronics, Inc.Inventors: C. Frederick Battrell, Denise Maxine Hoekstra, Joan Haab, John R. Williford, Sabrina N. Gates, Elizabeth R. Leber, Isaac Sprague
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Publication number: 20120142070Abstract: Formulations for dry storage of PCR reagents are described. These formulations find use in manufacture of self-contained microfluidic card devices for PCR clinical testing in which the reagents are reconstituted at the point of testing. In these cards, TAQ polymerase is stored “on-board” in vitrified dry form without lyophilization or freezing, and is reconstituted by either the sample or a sample eluate during the assay.Type: ApplicationFiled: December 12, 2011Publication date: June 7, 2012Applicant: Micronics, Inc.Inventors: C. Frederick Battrell, Denise Maxine Hoekstra, Joan Haab, John R. Williford
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Publication number: 20120064597Abstract: Disclosed herein is a device comprising a pair of bellows pumps configured for efficient mixing at a microfluidic scale. By moving a fluid sample and particles in suspension through an aperture between the paired bellows pump mixing chambers, molecular collisions leading to binding between the particles and ligands in the sample are enhanced. Such devices provide an alternative for mixing that does not use a vent and can be used with a variety of particles in suspension such as magnetic beads to capture or purify useful cells and molecules.Type: ApplicationFiled: May 2, 2011Publication date: March 15, 2012Applicant: Micronics, Inc.Inventors: John Clemmens, C. Frederick Battrell, John Gerdes, Denise Maxine Hoekstra
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Patent number: 8110392Abstract: Microfluidic methods and devices for heterogeneous binding and agglutination assays are disclosed, with improvements relating to mixing and to reagent and sample manipulation in systems designed for safe handling of clinical test samples.Type: GrantFiled: December 22, 2008Date of Patent: February 7, 2012Assignee: Micronics, Inc.Inventors: C Frederick Battrell, John Gerdes, Stephen Mordue, Jason Capodanno, Denise Maxine Hoekstra, John R Williford, John Clemmens
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Patent number: 7955836Abstract: Disclosed herein is a device comprising a pair of bellows pumps configured for efficient mixing at a microfluidic scale. By moving a fluid sample and particles in suspension through an aperture between the paired bellows pump mixing chambers, molecular collisions leading to binding between the particles and ligands in the sample are enhanced. Such devices provide an alternative for mixing that does not use a vent and can be used with a variety of particles in suspension such as magnetic beads to capture or purify useful cells and molecules.Type: GrantFiled: January 11, 2010Date of Patent: June 7, 2011Assignee: Micronics, Inc.Inventors: John Clemmens, C. Frederick Battrell, John Gerdes, Denise Maxine Hoekstra
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Patent number: 7763453Abstract: Disclosed herein is a device comprising a pair of bellows pumps configured for efficient mixing at a microfluidic scale. By moving a fluid sample and particles in suspension through an aperture between the paired bellows pump mixing chambers, molecular collisions leading to binding between the particles and ligands in the sample are enhanced. Such devices provide an alternative for mixing that does not use a vent and can be used with a variety of particles in suspension such as magnetic beads to capture or purify useful cells and molecules.Type: GrantFiled: November 22, 2006Date of Patent: July 27, 2010Assignee: Micronics, Inc.Inventors: John Clemmens, C. Frederick Battrell, John Gerdes, Denise Maxine Hoekstra
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Publication number: 20100167384Abstract: Disclosed herein is a device comprising a pair of bellows pumps configured for efficient mixing at a microfluidic scale. By moving a fluid sample and particles in suspension through an aperture between the paired bellows pump mixing chambers, molecular collisions leading to binding between the particles and ligands in the sample are enhanced. Such devices provide an alternative for mixing that does not use a vent and can be used with a variety of particles in suspension such as magnetic beads to capture or purify useful cells and molecules.Type: ApplicationFiled: January 11, 2010Publication date: July 1, 2010Applicant: Micronics, Inc,Inventors: John Clemmens, C. Frederick Battrell, John Gerdes, Denise Maxine Hoekstra
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Publication number: 20090325276Abstract: Combinations of microfluidic diagnostic testing modules for simultaneous evaluations of serological and molecular biological targets are provided, and include panel testing for both antibodies (or antigens) and nucleic acid targets in one single-use device. These improvements are directed to evaluating the overall progress and activity of a pathogenic process in real time, at the point of care, not merely the presence or absence of a particular diagnostic marker, which can often be incomplete or misleading.Type: ApplicationFiled: March 25, 2009Publication date: December 31, 2009Applicant: Micronics, Inc.Inventors: C. Frederick Battrell, John Gerdes, Wayne L. Breidford, Jason Capodanno, Stephen Mordue, John Clemmens, Denise Maxine Hoekstra, Christy A. Lancaster, John R. Williford, Patrick Maloney, Joan Haab
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Publication number: 20090181411Abstract: Microfluidic methods and devices for heterogeneous binding and agglutination assays are disclosed, with improvements relating to mixing and to reagent and sample manipulation in systems designed for safe handling of clinical test samples.Type: ApplicationFiled: December 22, 2008Publication date: July 16, 2009Applicant: Micronics, Inc.Inventors: C. Frederick Battrell, John Gerdes, Stephen Mordue, Jason Capodanno, Denise Maxine Hoekstra, John R. Williford, John Clemmens
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Publication number: 20090148933Abstract: Integrated microfluidic cartridges for nucleic acid extraction, amplification, and detection from clinical samples are disclosed. The devices are single-entry, sanitary, and disposable. The devices enable simplex or multiplex nucleic acid target detection, as for example: assay panels for multiple infectious agents, or assay panels for cancerous cell types. Methods for use of microfluidic cartridges in a fully automated, pneumatically controlled apparatus are also disclosed.Type: ApplicationFiled: September 10, 2008Publication date: June 11, 2009Applicant: Micronics, Inc.Inventors: C. Frederick Battrell, John Gerdes, John R. Williford, Denise Maxine Hoekstra, Wayne L. Breidford, Stephen Mordue, John Clemmens, Melud Nabavi, Mark Kokoris
