Patents by Inventor Denise O'Keefe

Denise O'Keefe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD OF DETERMINING THE PROGNOSIS OF HUMAN CANCER
    Publication number: 20080044832
    Abstract: The invention provides methods and kits of diagnosing or determining the prognosis of a cancer in a mammal comprising determining the methylation status of the (15)-Lipoxygenase type 1 (15-LO-1) promoter in the mammal's tissue, specifically, the methylation status of the 10th CpG dinucleotide of the 15-LO-1 promoter as defined by nucleotides 727-728 of SEQ ID NO:1 in the tissue sample. The methods can include detecting the methylation status of DNA in a tissue sample, or by measuring the expression level of 15-LO-1 protein or mRNA.
    Type: Application
    Filed: April 19, 2007
    Publication date: February 21, 2008
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Uddhav Kelavkar, Rajiv Dhir, Denise O'Keefe
  • DNA encoding the prostate-specific membrane antigen-like gene and uses thereof
    Patent number: 6897062
    Abstract: The present invention discloses a new gene, termed PSMA-like, that is very similar to the prostate-specific membrane antigen (PSMA) gene and cross-reacts with current detection methods for PSMA. The present invention also provides for a method of distinguishing the PSMA and PSMA-like mRNAs and/or proteins for diagnostic and therapeutic strategies that desire specific targeting of either the PSMA or PSMA-like gene.
    Type: Grant
    Filed: October 9, 2001
    Date of Patent: May 24, 2005
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Warren Heston, Denise O'Keefe
  • DNA encoding the prostate-specific membrane antigen-like gene and uses thereof
    Publication number: 20050064504
    Abstract: The present invention discloses a new gene, termed PSMA-like, that is very similar to the prostate-specific membrane antigen (PSMA) gene and cross-reacts with current detection methods for PSMA. The present invention also provides for a method of distinguishing the PSMA and PSMA-like mRNAs and/or proteins for diagnostic and therapeutic strategies that desire specific targeting of either the PSMA or PSMA-like gene.
    Type: Application
    Filed: November 17, 2004
    Publication date: March 24, 2005
    Inventors: Warren Heston, Denise O'Keefe