Patents by Inventor Denise SABATINO

Denise SABATINO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Expression cassette for packaging and expression of variant factor VIII for the treatment of hemostasis disorders
    Patent number: 11014975
    Abstract: Factor VIII variants and methods of use thereof are disclosed. In particular embodiments, Factor VIII variants are expressed more efficiently by cells over wild-type Factor VIII proteins, are secreted at increased levels by cells over wild-type Factor VIII proteins, exhibit enhanced activity over wild-type Factor VIII proteins and are packaged more efficiently into viral vectors.
    Type: Grant
    Filed: August 13, 2015
    Date of Patent: May 25, 2021
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Denise Sabatino, Katherine A. High, Liron Elkouby
  • AN IMPROVED EXPRESSION CASSETTE FOR PACKAGING AND EXPRESSION OF VARIANT FACTOR VIII FOR THE TREATMENT OF HEMOSTASIS DISORDERS
    Publication number: 20170233456
    Abstract: Factor VIII variants and methods of use thereof are disclosed. In particular embodiments, Factor VIII variants are expressed more efficiently by cells over wild-type Factor VIII proteins, are secreted at increased levels by cells over wild-type Factor VIII proteins, exhibit enhanced activity over wild-type Factor VIII proteins and are packaged more efficiently into viral vectors.
    Type: Application
    Filed: August 13, 2015
    Publication date: August 17, 2017
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Denise SABATINO, Katherine A. HIGH, Liron ELKOUBY