Abstract: Biological sample processing system comprising an imaging unit comprising a digital image processing system and at least one microscope including at least one lens, a sample processing station comprising a handling platform including a support and a displacement mechanism for moving the support, and a sample processing unit mounted on the handling platform. The sample processing unit comprises a tissue slide holder for mounting thereon a tissue slide with a biological sample fixed thereon and a microfluidic cartridge holder for mounting a microfluidic cartridge thereon. The tissue slide holder is coupled to the microfluidic cartridge holder via a coupling allowing the microfluidic cartridge and the tissue support to be mounted and removed from the sample processing unit in an opened position, and in a closed position for the tissue support to be in sealing contact with the microfluidic cartridge.

Abstract: Biological sample processing system comprising an imaging unit (2) comprising a digital image processing system and at least one microscope including at least one lens (14), a sample processing station (3) comprising a handling platform (3) including a support (17) and a displacement mechanism for moving the support (17), and a sample processing unit (7) mounted on the handling platform (5). The sample processing unit (7) comprises a tissue slide holder (11) for mounting thereon a tissue slide (34) with a biological sample (36) fixed thereon and a microfluidic cartridge holder (9) for mounting a microfluidic cartridge (4) thereon. The tissue slide holder (11) is coupled to the microfluidic cartridge holder (9) via a coupling (13) allowing the microfluidic cartridge and the tissue support to be mounted and removed from the sample processing unit in an opened position, and in a closed position for the tissue support (34) to be in sealing contact with the microfluidic cartridge (4).

Abstract: Biological sample processing system comprising an imaging unit (2) comprising a digital image processing system and at least one microscope including at least one lens (14), a sample processing station (3) comprising a handling platform (3) including a support (17) and a displacement mechanism for moving the support (17), and a sample processing unit (7) mounted on the handling platform (5). The sample processing unit (7) comprises a tissue slide holder (11) for mounting thereon a tissue slide (34) with a biological sample (36) fixed thereon and a microfluidic cartridge holder (9) for mounting a microfluidic cartridge (4) thereon. The tissue slide holder (11) is coupled to the microfluidic cartridge holder (9) via a coupling (13) allowing the microfluidic cartridge and the tissue support to be mounted and removed from the sample processing unit in an opened position, and in a closed position for the tissue support (34) to be in sealing contact with the microfluidic cartridge (4).

Abstract: Microfluidic cartridge (10) comprising a sampling device (30) having a sealing ring (32) arranged to form a microfluidic chamber (31) when a support containing a biological sample is brought into contact with the sealing ring, and a microfluidic network device (13) configured to supply reagents to the microfluidic chamber. The sampling device further comprises inlet and outlet distribution networks (33a, 33b) in fluid communication with the microfluidic chamber and a slide holder (35) to guide and position said support containing a biological sample on the sampling device. The microfluidic network device comprises a plurality of reagent inlet channels (18) fluidly connectable to reagent sources, at least one reagent outlet channel (22) fluidly connected to the sampling device inlet distribution network (33a), and a plurality of valves (25) operable to selectively connect the inlet channels to the at least one outlet channel.

Abstract: Microfluidic cartridge (10) comprising a sampling device (30) having a sealing ring (32) arranged to form a microfluidic chamber (31) when a support containing a biological sample is brought into contact with the sealing ring, and a microfluidic network device (13) configured to supply reagents to the microfluidic chamber. The sampling device further comprises inlet and outlet distribution networks (33a, 33b) in fluid communication with the microfluidic chamber and a slide holder (35) to guide and position said support containing a biological sample on the sampling device. The microfluidic network device comprises a plurality of reagent inlet channels (18) fluidly connectable to reagent sources, at least one reagent outlet channel (22) fluidly connected to the sampling device inlet distribution network (33a), and a plurality of valves (25) operable to selectively connect the inlet channels to the at least one outlet channel.