Patents by Inventor Dennis A. Carson

Dennis A. Carson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7129262
    Abstract: The present invention provides novel indole derivatives useful to inhibit cancer or sensitize cancer cells to chemotherapeutic agents, radiation or other anti-cancer treatments.
    Type: Grant
    Filed: December 16, 2004
    Date of Patent: October 31, 2006
    Assignee: The Regents of The University of California
    Inventors: Dennis A. Carson, Howard B. Cottam, Lorenzo M. Leoni
  • Patent number: 7105560
    Abstract: A method of treating multiple myeloma (MM) is provided comprising administering an amount of etodolac to a subject afflicted with MM that is effective to selectively reduce the viability of and/or to sensitize the cancer cells to an anti-cancer agent.
    Type: Grant
    Filed: June 7, 2000
    Date of Patent: September 12, 2006
    Assignee: The Regents of The University of California
    Inventors: Dennis A. Carson, Howard B. Cottam, Souchi Adachi, Lorenzo M. Leoni
  • Patent number: 7105561
    Abstract: A method of treating cancer is provided comprising administering an amount of etodolac to a subject afflicted with cancer that is effective to reduce the viability and/or to sensitize the cancer to an anti-cancer agent.
    Type: Grant
    Filed: September 5, 2002
    Date of Patent: September 12, 2006
    Assignee: The Regents of The University of California
    Inventors: Dennis A. Carson, Howard B. Cottam, Souchi Adachi, Lorenzo M. Leoni
  • Patent number: 7098216
    Abstract: The invention provides derivatives of thiazolo[4,5-d1]pyrimidine and their use as inhibitors of proinflammatory cytokines.
    Type: Grant
    Filed: September 28, 2004
    Date of Patent: August 29, 2006
    Assignee: The Regents of the University of California
    Inventors: Dennis A. Carson, Howard B. Cottam, Lynn Deng
  • Patent number: 7094597
    Abstract: Vaccine compositions useful in inducing immune protection in a host against arthritogenic peptides involved in the pathogenesis of rheumatoid arthritis are disclosed. Each vaccine composition provides antigenic dnaJp1 peptide (by including the peptide or a polynucleotide which encodes the peptide) and, optionally, other peptide fragments of the microbial dnaJ protein and/or human homologs thereof. Methods for identifying persons who are predisposed to develop rheumatoid arthritis and methods for use of the inventive vaccines are also disclosed.
    Type: Grant
    Filed: July 14, 2000
    Date of Patent: August 22, 2006
    Assignee: The Regents of the University of California
    Inventors: Dennis A. Carson, Salvatore Albani
  • Patent number: 6951845
    Abstract: The invention is directed to a method for treating both the early and late phases of allergic asthma by introducing naked polynucleotides which operatively encode for the asthma-initiating antigen into the host. The antigen-encoding polynucleotides are administered to host tissues which contain a high concentration of antigen presenting cells (e.g., skin and mucosa) relative to other host tissues. Expression of the asthma-initiating antigen encoding polynucleotides of the invention inside of antigen presenting cells (without substantial secretion therefrom) induces antigen tolerance while suppressing IgE antibody formation in the early phase of the disease, and also suppresses cytokine-mediated eosinophil accumulation in the late phase of the disease. Devices and compositions for use in the methods of the invention are also described.
    Type: Grant
    Filed: May 13, 2002
    Date of Patent: October 4, 2005
    Assignee: The Regents of the University of California
    Inventors: Dennis A. Carson, Eyal Raz
  • Patent number: 6946132
    Abstract: Vaccine compositions useful in inducing immune protection in a host against arthritogenic peptides involved in the pathogenesis of rheumatoid arthritis are disclosed. Each vaccine composition provides antigenic dnaJp1 peptide (by including the peptide or a polynucleotide which encodes the peptide) and, optionally, other peptide fragments of the microbial dnaJ protein and/or human homologs thereof. Methods for identifying persons who are predisposed to develop rheumatoid arthritis and methods for use of the inventive vaccines are also disclosed.
    Type: Grant
    Filed: November 18, 2002
    Date of Patent: September 20, 2005
    Assignee: The Regents of the University of California
    Inventors: Dennis A. Carson, Salvatore Albani
  • Patent number: 6930101
    Abstract: The invention provides derivatives of thiazolo[4,5-dl]pyrimidine and their use as inhibitors of proinflammatory cytokines.
    Type: Grant
    Filed: May 17, 1999
    Date of Patent: August 16, 2005
    Assignee: The Regents of the University of California
    Inventors: Dennis A. Carson, Howard B. Cottam, Lynn Deng
  • Patent number: 6911309
    Abstract: A method for detecting whether methyladenosine phosphatase (MTAse) is present in a cell sample. In one respect, the method comprises adding oligonucleotide probes to the sample, which probes are capable of specifically hybridizing to any MTAse encoding nucleic acid in the sample under conditions favoring that hybridization. Absence of MTAse in a sample is considered to be indicative of malignancy. Polynucleotides encoding MTAse, MTAse peptides and antibodies to MTAse, as well as kits for performing the methods of the invention, are provided.
    Type: Grant
    Filed: February 9, 2001
    Date of Patent: June 28, 2005
    Assignee: The Regents of the University of Californnia
    Inventors: Tsutomu Nobori, Dennis A. Carson, Kenji Takabayashi
  • Patent number: 6867195
    Abstract: A method for delivering an isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of an isolated polynucleotide into a tissue of the vertebrate where the polynucleotide is taken up by the cells of the tissue and exerts a therapeutic effect on the vertebrate. The method can be used to deliver a therapeutic polypeptide to the cells of the vertebrate, to provide an immune response upon in vivo translation of the polynucleotide, to deliver antisense polynucleotides, to deliver receptors to the cells of the vertebrate, or to provide transitory gene therapy.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 15, 2005
    Assignee: Vical Incorporated
    Inventors: Philip L. Felgner, Jon Asher Wolff, Gary H. Rhodes, Robert Wallace Malone, Dennis A. Carson
  • Publication number: 20040203003
    Abstract: The diverse receptor-ligand pairs of the Wnt and frizzled (Fzd) families play important roles during embryonic development, and thus may be overexpressed in cancers that arise from immature cells. The mRNA levels and expression levels of 5 Wnt (Wnt-1, 5a, 7a, 10b, 13) and 2 Fzd (Fzd-2, 5) genes in 10 head and neck squamous carcinoma cell lines (HNSCC) were investigated. In addition, anti-Wnt-1 antibodies were used to study the Wnt/Fzd signalling pathway. These results indicate that HNSCC cell lines overexpress one or more Wnt and Fzd genes, and the growth and survival of a subset of HNSCC may depend on the Wnt/Fzd pathway. Therefore, The Wnt and Fzd receptors may be useful targets for immunotherapy of this common cancer.
    Type: Application
    Filed: March 5, 2004
    Publication date: October 14, 2004
    Inventors: Chae-Seo Rhee, Malini Sen, Christina Wu, Lorenzo M Leoni, Maripat Corr, Dennis A Carson
  • Publication number: 20040152672
    Abstract: The present invention provides a method for treating a cancer in a mammal comprising administering an effective amount of an indole compound, in combination with an alkylating agent; to a mammal afflicted with cancer.
    Type: Application
    Filed: October 9, 2003
    Publication date: August 5, 2004
    Inventors: Dennis A. Carson, Lorenzo M. Leoni, Howard B. Cottam
  • Publication number: 20040147582
    Abstract: A method of treating cancer is provided comprising administering an amount of etodolac or analog theteof to a subject afflicted with leukemia that is effective to reduce the viability and/or to sensitize leukemia cells to an anti-cancer agent.
    Type: Application
    Filed: January 8, 2004
    Publication date: July 29, 2004
    Applicant: University of California Regents
    Inventors: Dennis A. Carson, Howard B. Cottam, Souchi Adachi, Lorenzo M. Leoni
  • Publication number: 20040132683
    Abstract: A method for delivering a naked or isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of a naked polynucleotide into a tissue of the vertebrate where the polynucleotide is taken up by the cells of the tissue and exerts a therapeutic effect on the vertebrate. The method can be used to deliver a therapeutic polypeptide to the cells of the vertebrate, to provide an immune response upon in vivo translation of the polynucleotide, to deliver antisense polynucleotides, to deliver receptors to the cells of the vertebrate, or to provide transitory gene therapy.
    Type: Application
    Filed: December 11, 2003
    Publication date: July 8, 2004
    Applicant: Vical Incorporated
    Inventors: Philip L. Felgner, Jon Asher Wolff, Gary H. Rhodes, Robert Wallace Malone, Dennis A. Carson
  • Publication number: 20040127431
    Abstract: The present invention provides a therapeutic method to treat non-malignant diseases characterized by the excessive tissue growth, e.g., hyperplastic diseases, comprising administering to a mammal (e.g.
    Type: Application
    Filed: September 19, 2003
    Publication date: July 1, 2004
    Inventors: Dennis A. Carson, Lorenzo M. Leoni, Mary Patricia Corr
  • Publication number: 20040127435
    Abstract: The present invention provides methods of treating cancer using inhibitors of inosine monophosphate dehydrogenase (IMPDH). The IMPDH inhibitors are combined with compounds that inhibit cellular processes regulated by GTP or ATP. Also provided are prodrugs of the IMPDH inhibitor mizoribine and its aglycone. The prodrugs are useful in practicing the methods of the invention, including immunosuppressive therapy and treatment of cancer by prolonged administration without additional therapeutic compounds.
    Type: Application
    Filed: August 1, 2003
    Publication date: July 1, 2004
    Applicant: REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Dennis A. Carson, Lorenzo M. Leoni, Howard B. Cottam
  • Publication number: 20040096436
    Abstract: The present invention provides methods of treating cancer using inhibitors of protein kinases. The inhibitors of protein kinases are combined with agents that inhibit a cellular ATP synthetic pathway. Inhibitors of ATP synthesis include inhibitors of de novo purine biosynthesis, inhibitors of the salvage pathway of ATP biosynthesis, and inhibitors of the enzyme inosine monophosphate dehydrogenase.
    Type: Application
    Filed: August 1, 2003
    Publication date: May 20, 2004
    Applicants: REGENTS OF THE UNIVERSITY OF CALIFORNIA, SALMEDIX, INC.
    Inventors: Dennis A. Carson, Michael D. Rosenbach, Carlos J. Carrera, Lorenzo M. Leoni
  • Patent number: 6710035
    Abstract: A method for delivering an isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of an isolated polynucleotide into a tissue of the vertebrate where the polynucleotide is taken up by the cells of the tissue and exerts a therapeutic effect on the vertebrate. The method can be used to deliver a therapeutic polypeptide to the cells of the vertebrate, to provide an immune response upon in vivo translation of the polynucleotide, to deliver antisense polynucleotides, to deliver receptors to the cells of the vertebrate, or to provide transitory gene therapy.
    Type: Grant
    Filed: December 2, 1999
    Date of Patent: March 23, 2004
    Assignees: Vical Incorporated, Wisconsin Alumni Research Foundation
    Inventors: Philip L. Felgner, Jon Asher Wolff, Gary H. Rhodes, Robert Wallace Malone, Dennis A. Carson
  • Patent number: 6696441
    Abstract: The present invention provides compounds that act to suppress p53 activity in mammalian cells, and a method to effectively suppress p53 activity in the cells of a mammal subject to a stress or pathology that is ameliorated by such suppression.
    Type: Grant
    Filed: August 11, 2000
    Date of Patent: February 24, 2004
    Assignee: The Regents of the University of California
    Inventors: Howard B. Cottam, Lorenzo M. Leoni, Dennis A. Carson
  • Patent number: 6689864
    Abstract: A gene that encodes an inhibitor of CDK4 has been discovered and its genomic nucleotide sequence has been identified. Susceptibility to certain cancers has been shown to be causatively related to the deletion of, or polymorphisms in, the CDK4I gene. The invention is therefore directed to the gene (CDK4I), the inhibitor protein, as well as therapeutic and diagnostic methods which utilize both the CDK4I gene and the CDK4I protein.
    Type: Grant
    Filed: August 26, 1997
    Date of Patent: February 10, 2004
    Assignee: The Regents of the University of California
    Inventors: Dennis A. Carson, Tsutomu Nobori