Abstract: A resistance band system including a frame-assembly, a plurality of linear-straps, and a plurality of removable-D-rings. The frame-assembly, the plurality of linear-straps and plurality of removable-D-rings of the resistance band system are structured and arranged in combination to allow a user to affix a linear-resistance-band to the resistance band system to provide an overall exercise system which provides the user with a plurality of locations to affix the linear-resistance-band to the resistance band system to allow a highly flexible and diverse exercise system to the user. The frame-assembly includes an upper-frame, a lower-frame, and a u-member. The upper-frame includes two primary-members, two inbars, two forward-bars, and a crown-bar. The lower-frame includes two first-members, two downbars, and down-cross-member. The u-member comp includes rises a body, two legs, and two t-couplers, with u-member rotatably coupled to the lower-frame via the two t-couplers.

Abstract: A resistance band system including a frame-assembly, a plurality of linear-straps, and a plurality of removable-D-rings. The frame-assembly, the plurality of linear-straps and plurality of removable-D-rings of the resistance band system are structured and arranged in combination to allow a user to affix a linear-resistance-band to the resistance band system to provide an overall exercise system which provides the user with a plurality of locations to affix the linear-resistance-band to the resistance band system to allow a highly flexible and diverse exercise system to the user. The frame-assembly includes an upper-frame, a lower-frame, and a u-member. The upper-frame includes two primary-members, two inbars, two forward-bars, and a crown-bar. The lower-frame includes two first-members, two downbars, and down-cross-member. The u-member comp includes rises a body, two legs, and two t-couplers, with u-member rotatably coupled to the lower-frame via the two t-couplers.

Abstract: New compounds are disclosed for multimerizing immunophilins and proteins containing immunophilin or immunophilin-related domains. The compounds are of the formula M-L-Q where M is a synthetic ligand for an FKBP protein.

Abstract: New compounds are disclosed for multimerizing immunophilins and proteins containing immunophilin or immunophilin-related domains. The compounds are of the formula M-L-Q where M is a synthetic ligand for an FKBP protein.

Abstract: New compounds are disclosed for multimerizing immunophilins and proteins containing immunophilin or immunophilin-related domains. The compounds are of the formula M-L-Q where M is a synthetic ligand for an FKBP protein.

Abstract: A stringed instrument including a housing defining an interior space, at least one string on the housing, an amplifier positioned in the interior space and attached to the housing and a pick-up on the housing and positioned adjacent to the string where the pick-up converts vibrations from the string into electrical signals and transmits the electrical signals to the amplifier. The stringed instrument includes an audio input on the housing and coupled to the amplifier, where the audio input is coupled to a digital music player and sound stored by the digital music player is coupled to the amplifier. At least one speaker is mounted in the housing and coupled to the amplifier. The amplifier converts electrical signals from the pick-up into live music and the speaker emits both the live music and the sound from the digital music player to enable a player to play along with the sound.

Abstract: Methods and materials involving 28-epirapamycin analogs are disclosed.

Abstract: Rapamycin derivatives containing substituents at C-28 in the epi orientation relative to rapamycin are disclosed, together with methods for their preparation and use, e.g. for regulation of biological phenomena in engineered cells. The compounds may contain optional additional modifications relative to rapamycin, as disclosed herein.

Abstract: Methods and materials involving 28-epirapamycin analogs are disclosed.

Abstract: Materials and methods are disclosed for regulation of biological events such as target gene transcription and growth, proliferation or differentiation of engineered cells.

Abstract: This invention concerns derivatives of rapamycin and their antifungal uses. Also disclosed are materials and methods relevant to the identification of non-immunosuppressive anti-fungal rapamycin derivatives. Use of compounds, among others, of the formula is disclosed, where the various substitutents are as defined.

Abstract: New compounds are disclosed for multimerizing immunophilins and proteins containing immunophilin or immunophilin-related domains.

Abstract: Materials and methods are disclosed for regulation of biological events such as target gene transcription and growth, proliferation or differentiation of engineered cells.

Abstract: This invention concerns new configurations for biological switches and provides new methods and materials useful for regulating biological events in animal cells. The invention involves recombinant DNA constructs comprising DNA sequences derived from sequences encoding the proteins FRAP, Tor1, Tor2 and other proteins capable of binding to FKBP:rapamycin, other recombinant DNA constructs comprising DNA sequences encoding part or all of an FKBP protein, the proteins encoded by those constructs, cells (especially animal cells) transformed with one or more of the constructs, small molecules (multivalent multimerizing agents) which bind to and are capable of inducing multimerization of the chimeric proteins, and methods for preparing and using the foregoing, including methods involving the intramuscular delivery of such recombinant DNA constructs in AAV virus particles.

Abstract: Invented is a method of treating a bone resorption disease in a subject which comprises administering to the subject a therapeutically effective amount of a compound which forms a covalent bond or link to cys 185 of the src SH2 domain.

Abstract: New compounds are disclosed for multimerizing immunophilins and proteins containing immunophilin or immunophilin-related domains.

Abstract: This invention concerns new configurations for biological switches and provides new methods and materials useful for regulating biological events in animal cells. The invention involves recombinant DNA constructs comprising DNA sequences derived from sequences encoding the proteins FRAP, Tor1, Tor2 and other proteins capable of binding to FKBP:rapamycin, other recombinant DNA constructs comprising DNA sequences encoding part or all of an FKBP protein, the proteins encoded by those constructs, cells (especially animal cells) transformed with one or more of the constructs, small molecules (multivalent multimerizing agents) which bind to and are capable of inducing multimerization of the chimeric proteins, and methods for preparing and using the foregoing, including methods involving the intramuscular delivery of such recombinant DNA constructs in AAV virus particles.

Abstract: This invention concerns derivatives of rapamycin and their antifungal uses. Also disclosed are materials and methods relevant to the identification of non-immunosuppressive anti-fungal rapamycin derivatives.

Abstract: New compounds are disclosed for multimerizing immunophilins and proteins containing immunophilin or immunophilin-related domains.

Abstract: Materials and methods are disclosed for regulation of biological events such as target gene transcription and growth, proliferation or differentiation of engineered cells.