Abstract: Methods, devices, and system related to cross-domain routing of communication session requests in Internet Protocol (IP) Multimedia Subsystem are disclosed. In one example aspect, a method for routing a call initiated in an IP Multimedia Subsystem (IMS) includes receiving, by a Breakout Gateway Control Function (BGCF) node operating in a first domain, a first message from a caller requesting an establishment of a communication session. The method includes determining, by the BGCF node based on header information of the first message, that the caller is located in a second domain different than the first domain, and generating, by the BGCF node, a second message based on a preconfigured rule for the second domain.

Abstract: The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

Abstract: Systems and methods are provided for precise location-based routing of calls. After a user device originates a non-short code call to a jurisdiction specific number, one or more networked computer processing components utilize the location of the originating user device to generate a location-based translated number. The location-based translated number combines the higher-precision location of the originating device with the destination number, causing the call to be routed to a destination more likely to be associated with the jurisdiction from which the call originated.

Abstract: Methods, devices, and system related to wireless communications are disclosed. In one example aspect, a method for wireless communications includes receiving, by a network node in a communication network, a packet associated with a call that has been initiated for a user device, and determining, by the network node, location information carried in a header of the packet. The method also includes determining, by the network node using a mapping between location information and Major Trading Area (MTA) values, an MTA value corresponding to the location information carried in the header, and routing, by the network node based on the MTA value, the packet using a routing path that bypasses a circuit-switched based network.

Abstract: Methods and compositions are provided for the use of anti-CRISPR (ACR) proteins in plants, including modulation of Cas endonuclease activity, improvement of frequency of homologous recombination, control of Cas endonuclease activity during various cell cycles, spatial and/or temporal regulation of Cas endonuclease activity in plants, usage in gene activation or repression, as well as reduction of off-target polynucleotide cleavage.

Abstract: Methods, devices, and system related to wireless communications are disclosed. In one example aspect, a method for wireless communications includes receiving, by a network node in a communication network, a packet associated with a call that has been initiated for a user device, and determining, by the network node, location information carried in a header of the packet. The method also includes determining, by the network node using a mapping between location information and Major Trading Are (MTA) values, a MTA value corresponding to the location information carried in the header, and routing, by the network node based on the MTA value, the packet using a routing path that bypasses a circuit-switched based network.

Abstract: A Breakout Gateway Control Function (BGCF) determines a geographic location information (e.g., a major trading area (MTA) information) from a SIP INVITE header information (e.g., from a P-Access-Network-Info (PANI) header information) and modifies the SIP URI in the SIP INVITE request by adding, deleting, or modifying values (e.g., prepending a number prefix to the URI) to generate a SIP URI that is based on the geographic location information.

Abstract: Methods, devices, and system related to cross-domain routing of communication session requests in Internet Protocol (IP) Multimedia Subsystem are disclosed. In one example aspect, a method for routing a call initiated in an IP Multimedia Subsystem (IMS) includes receiving, by a Breakout Gateway Control Function (BGCF) node operating in a first domain, a first message from a caller requesting an establishment of a communication session. The method includes determining, by the BGCF node based on header information of the first message, that the caller is located in a second domain different than the first domain, and generating, by the BGCF node, a second message based on a preconfigured rule for the second domain.

Abstract: The invention relates to anti-CRISPR genes and anti-CRISPR proteins, and their uses in various biotechnology applications.

Abstract: The present invention relates to a lactic acid bacterium, in particular a strain of the Streptococcus genus, with reduced sensitivity to cos-type bacteriophages. The invention also relates to methods to engineer these lactic acid bacteria as well as their use to ferment milk.

Abstract: Methods and compositions are provided for the use of anti-CRISPR (ACR) proteins in plants, including modulation of Cas endonuclease activity, improvement of frequency of homologous recombination, control of Cas endonuclease activity during various cell cycles, spatial and/or temporal regulation of Cas endonuclease activity in plants, usage in gene activation or repression, as well as reduction of off-target polynucleotide cleavage.

Abstract: The invention relates to CRISPR sequences found in bifidobacteria and their uses.

Abstract: The present invention relates to the use of one or more cas genes for modulating resistance in a cell against a target nucleic acid or a transcription product thereof.

Abstract: The invention relates to anti-CRISPR genes and anti-CRISPR proteins, and their uses in various biotechnology applications

Abstract: The present invention relates to the use of one or more cas genes for modulating resistance in a cell against a target nucleic acid or a transcription product thereof.

Abstract: The present invention provides methods and compositions related to modulating the resistance of a cell against a target nucleic acid or a transcription product thereof. In some preferred embodiments, the present invention provides compositions and methods for the use of one or more cas genes or proteins for modulating the resistance of a cell against a target nucleic acid or a transcription product thereof. In some embodiments, the present invention provides methods and compositions that find use in the development and use of strain combinations and starter culture rotations. In additional embodiments, the present invention provides methods for labelling and/or identifying bacteria. In some preferred embodiments, the present invention provides methods for the use of CRISPR loci to determine the potential virulence of a phage against a cell and the use of CRISPR-cas to modulate the genetic sequence of a phage for increased virulence level.

Abstract: The present invention relates to a nucleic acid comprising a Lactococcus CRISPR repeat region and/or a Lactococcus CRISPR spacer region.

Abstract: The present invention relates to the use of one or more cas genes for modulating resistance in a cell against a target nucleic acid or a transcription product thereof.

Abstract: The present invention provides methods for tagging and/or identifying microorganisms. In some preferred embodiments, the microorganisms are bacteria. In some particularly preferred embodiments, the bacteria are members of the genus Streptococcus, while in other embodiments, the bacteria are members of other genera. The present invention also provides microorganisms tagged using the methods set forth herein. In some preferred embodiments, the tagged microorganisms are bacteria. In some particularly preferred embodiments, the tagged bacteria are members of the genus Streptococcus, while in other embodiments, the tagged bacteria are members of other genera.

Abstract: The present invention relates to the use of one or more cas genes for modulating resistance in a cell against a target nucleic acid or a transcription product thereof.