Patents by Inventor Dennis A. WIGLE

Dennis A. WIGLE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Systems and methods for assessing properties of biological tubes
    Patent number: 10779732
    Abstract: A system and method is provided for measuring a mechanical property of a biological tube. The system and method operate to arrange a plurality of piezoelectric elements about the biological tube and apply a predetermined force or transduce an endogeneous or exogeneous force to the biological tube. The system and method also operate to receive a respective signal from each piezoelectric element in the plurality of piezoelectric elements responsive to the application of the predetermined force or a transduced endogenous or exogeneous force and calculate the mechanical property of the biological tube based on the signals received from the plurality of piezoelectric elements.
    Type: Grant
    Filed: March 22, 2017
    Date of Patent: September 22, 2020
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Johnathon M. Aho, Dennis A. Wigle, Matthew W. Urban
  • HYDROGEL BASED ENCAPSULATION DEVICE
    Publication number: 20200188558
    Abstract: Encapsulation devices comprising hydrogels are provided. Methods of making the encapsulation devices and methods of using the devices to provide implant cells, treat a disease, and prevent immunologic attack on implanted material are also provided.
    Type: Application
    Filed: June 12, 2018
    Publication date: June 18, 2020
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Yogish C. Kudva, Amit L. Garle, Dennis A. Wigle, Yasuhiro Ikeda, Michael J. Yaszemski
  • GENERATING HUMAN CELLS CAPABLE OF PRODUCING INSULIN IN RESPONSE TO GLUCOSE OR GLP-1
    Publication number: 20200190468
    Abstract: This document provides methods and materials related to generating human cells capable of producing insulin in response to glucose or GLP-1. For example, methods and materials for introducing nucleic acid vectors into human stem cells (e.g., human induced pluripotent stem cells) at particular stages of differentiation to create human cells having the ability to produce and secrete human insulin in response to glucose, GLP-1, or both glucose and GLP-1 as measured by a sensitive perifusion assay are provided.
    Type: Application
    Filed: April 24, 2018
    Publication date: June 18, 2020
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Yasuhiro Ikeda, Yaxi Zhu, Aleksey Matveyenko, Andre Terzic, Yogish C. Kudva, Dennis A. Wigle
  • Systems and Methods for Assessing Properties of Biological Tubes
    Publication number: 20170281006
    Abstract: A system and method is provided for measuring a mechanical property of a biological tube. The system and method operate to arrange a plurality of piezoelectric elements about the biological tube and apply a predetermined force or transduce an endogeneous or exogeneous force to the biological tube. The system and method also operate to receive a respective signal from each piezoelectric element in the plurality of piezoelectric elements responsive to the application of the predetermined force or a transduced endogenous or exogeneous force and calculate the mechanical property of the biological tube based on the signals received from the plurality of piezoelectric elements.
    Type: Application
    Filed: March 22, 2017
    Publication date: October 5, 2017
    Inventors: Johnathon M. Aho, Dennis A. Wigle, Matthew W. Urban
  • Esophageal mucosectomy systems, devices and methods
    Patent number: 9216054
    Abstract: Systems, devices, apparatus and methods that may be used for en bloc circumferential esophageal mucosal resection or ablation that can extend over only a selected portion or all of the length of the esophagus.
    Type: Grant
    Filed: November 4, 2011
    Date of Patent: December 22, 2015
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Stephen D. Gassivi, Dennis A. Wigle
  • Methods for replacing a circumferential segment of an esophagus
    Patent number: 9005275
    Abstract: This document provides methods and materials that can be used to replace a circumferential segment of an esophagus. For example, methods and materials that can be used to provide a tubular connection from one stump end of an esophagus to another stump end of the esophagus are provided.
    Type: Grant
    Filed: November 8, 2012
    Date of Patent: April 14, 2015
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Stephen D. Cassivi, Dennis A. Wigle
  • ESOPHAGEAL MUCOSECTOMY SYSTEMS, DEVICES AND METHODS
    Publication number: 20120143188
    Abstract: Systems, devices, apparatus and methods that may be used for en bloc circumferential esophageal mucosal resection or ablation that can extend over only a selected portion or all of the length of the esophagus.
    Type: Application
    Filed: November 4, 2011
    Publication date: June 7, 2012
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Stephen D. GASSIVI, Dennis A. WIGLE