Patents by Inventor Dennis Benjamin

Dennis Benjamin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF INHIBITION OF PROTEIN FUCOSYLATION IN VIVO USING FUCOSE ANALOGS
    Publication number: 20130129784
    Abstract: The invention provides methods and compositions for the inhibition of fucosylation of proteins, including antibodies, in vivo by administration of a fucose analog.
    Type: Application
    Filed: August 5, 2011
    Publication date: May 23, 2013
    Applicant: Seattle Genetics, Inc.
    Inventors: Peter Senter, Stephen Alley, Dennis Benjamin
  • Methods for synthesis of encoded libraries
    Patent number: 8410028
    Abstract: The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.
    Type: Grant
    Filed: March 18, 2011
    Date of Patent: April 2, 2013
    Assignee: GlaxoSmithKline LLC
    Inventors: Barry Morgan, Stephen Hale, Christopher C. Arico-Muendel, Matthew Clark, Richard Wagner, David I. Israel, Malcolm L. Gefter, Dennis Benjamin, Nils Jakob Vest Hansen, Malcolm J. Kavarana, Steffan Phillip Creaser, George J. Franklin, Paolo A. Centrella, Raksha A. Acharya
  • METHODS FOR SCREENING ANTIBODIES
    Publication number: 20120322686
    Abstract: The invention provides methods for making antibody conjugates for use in antibody screening assays and antibody conjugates produced by the claimed methods.
    Type: Application
    Filed: February 28, 2011
    Publication date: December 20, 2012
    Applicant: SEATTLE GENETICS, INC.
    Inventors: Robert Lyon, Dennis Benjamin, Maureen Ryan
  • CD19 Binding Agents and Uses Thereof
    Publication number: 20120294853
    Abstract: This invention, inter alia, relates to CD19 binding agents and methods of using such CD19 binding agents for treating disease.
    Type: Application
    Filed: June 21, 2012
    Publication date: November 22, 2012
    Applicant: Seattle Genetics, Inc.
    Inventors: Charlotte McDonagh, Charles G. Cerveny, Dennis Benjamin, Paul Carter, Hans Peter Gerber, Leigh Francisco
  • Antibody drug conjugates (ADC) that bind to 24P4C12 proteins
    Patent number: 8309093
    Abstract: Antibody drug conjugates (ADC's) that bind to 24P4C12 protein and variants thereof are described herein. 24P4C12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
    Type: Grant
    Filed: March 5, 2010
    Date of Patent: November 13, 2012
    Assignee: Agensys, Inc.
    Inventors: Jean Gudas, Aya Jakobovits, Zili An, Robert Kendall Morrison, Karen Jane Meyrick Morrison, Xiao-chi Jia, Dennis Benjamin, Ruth Moser, Peter Senter
  • METHODS FOR SYNTHESIS OF ENCODED LIBRARIES
    Publication number: 20120245040
    Abstract: The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.
    Type: Application
    Filed: March 4, 2011
    Publication date: September 27, 2012
    Applicant: GlaxoSmithKline
    Inventors: Barry Morgan, Stephen Hale, Christopher C. Arico-Muendel, Matthew Clark, Richard Wagner, David I. Israel, Malcolm L. Gefter, Dennis Benjamin, Nils Jakob Vest Hansen, Malcolm J. Kavarana, Steffen Phillip Creaser, George J. Franklin, Paolo A. Centrella, Raksha A. Acharya
  • CD19 binding agents and uses thereof
    Patent number: 8242252
    Abstract: This invention relates to CD 19 binding agents and methods of using such CD 19 binding agents for treating disease.
    Type: Grant
    Filed: May 17, 2011
    Date of Patent: August 14, 2012
    Assignee: Seattle Genetics, Inc.
    Inventors: Charlotte McDonagh, Charles G. Cerveny, Dennis Benjamin, Paul Carter, Hans Peter Gerber, Leigh Francisco
  • METHODS FOR IDENTIFYING COMPOUNDS OF INTEREST USING ENCODED LIBRARIES
    Publication number: 20120071329
    Abstract: The present invention provides a method for identifying a compound of interest by screening libraries of molecules which include an encoding oligonucleotide tag.
    Type: Application
    Filed: March 18, 2011
    Publication date: March 22, 2012
    Applicant: GlaxoSmithKline LLC
    Inventors: Barry Morgan, Stephen Hale, Christopher C. Arico-Muendel, Matthew Clark, Richard Wagner, David I. Israel, Malcolm L. Gefter, Dennis Benjamin, Nils Jakob Vest Hansen, Malcolm J. Kavarana, Steffen Phillip Creaser, George J. Franklin, Paolo A. Centrella, Raksha A. Acharya
  • CD19 BINDING AGENTS AND USES THEREOF
    Publication number: 20110312088
    Abstract: This invention, inter alia, relates to CD19 binding agents and methods of using such CD19 binding agents for treating disease.
    Type: Application
    Filed: May 17, 2011
    Publication date: December 22, 2011
    Applicant: Seattle Genetics, Inc.
    Inventors: Charlotte McDonagh, Charles G. Cerveny, Dennis Benjamin, Paul Carter, Hans Peter Gerber, Leigh Francisco
  • METHODS FOR SYNTHESIS OF ENCODED LIBRARIES
    Publication number: 20110251089
    Abstract: The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.
    Type: Application
    Filed: March 18, 2011
    Publication date: October 13, 2011
    Applicant: GlaxoSmithKline
    Inventors: Barry Morgan, Stephen Hale, Christopher C. Arico-Muendel, Matthew Clark, Richard Wagner, David I. Israel, Malcolm L. Gefter, Dennis Benjamin, Nils Jakob Vest Hansen, Malcolm J. Kavarana, Steffen Phillip Creaser, George J. Franklin, Paolo A. Centrella, Raksha A. Acharya
  • Methods for identifying compounds of interest using encoded libraries
    Patent number: 7989395
    Abstract: The present invention provides a method for identifying a compound of interest by screening libraries of molecules which include an encoding oligonucleotide tag.
    Type: Grant
    Filed: October 23, 2006
    Date of Patent: August 2, 2011
    Assignee: GlaxoSmithKline LLC
    Inventors: Barry Morgan, Stephen Hale, Christopher C. Arico-Muendel, Matthew Clark, Richard Wagner, David I. Israel, Malcolm L. Gefter, Dennis Benjamin, Nils Jakob Vest Hansen, Malcolm J. Kavarana, Steffen Phillip Creaser, George J. Franklin, Paolo A. Centrella, Raksha A. Acharya
  • Methods for synthesis of encoded libraries
    Patent number: 7972992
    Abstract: The present invention provides methods of synthesizing a molecule comprising a functional moiety which is operatively linked to an encoding oligonucleotide. The methods include providing an initiator compound comprising an initial functional moiety comprising n building blocks, wherein the initial functional moiety comprises at least one reactive group, and is operatively linked to an initial oligonucleotide; reacting the initiator compound with a building block comprising at least one complementary reactive group, under conditions suitable for reaction of the complementary reactive group to form a covalent bond; and reacting the initial oligonucleotide with an incoming oligonucleotide corresponding to the building block in the presence of an enzyme which catalyzes ligation of the initial oligonucleotide and the incoming oligonucleotide, under conditions suitable for ligation of the incoming oligonucleotide and the initial oligonucleotide to form an encoding oligonucleotide.
    Type: Grant
    Filed: December 17, 2004
    Date of Patent: July 5, 2011
    Assignee: Praecis Pharmaceuticals, Inc.
    Inventors: Barry Morgan, Stephen Hale, Christopher C. Arico-Muendel, Matthew Clark, Richard Wagner, David I. Israel, Malcolm L. Gefter, Dennis Benjamin, Nils Jakob Vest Hansen, Malcolm J. Kavarana, Steffen Phillip Creaser, George J. Franklin, Paolo A. Centrella, Raksha A. Acharya
  • Methods for synthesis of encoded libraries
    Patent number: 7972994
    Abstract: The present invention provides methods of synthesizing libraries of molecules comprising a functional moiety which is operatively linked to an encoding oligonucleotide, wherein the encoding oligonucleotide comprises a capping sequence containing degenerate nucleotides.
    Type: Grant
    Filed: June 9, 2006
    Date of Patent: July 5, 2011
    Assignee: GlaxoSmithKline LLC
    Inventors: Barry Morgan, Stephen Hale, Christopher C. Arico-Muendel, Matthew Clark, Richard Wagner, David I. Israel, Malcolm L. Gefter, Dennis Benjamin, Nils Jakob Vest Hansen, Malcolm J. Kavarana, Steffen Phillip Creaser, George J. Franklin, Paulo A. Centrella, Raksha A. Acharya
  • CD19 binding agents and uses thereof
    Patent number: 7968687
    Abstract: This invention relates to CD 19 binding agents and methods of using such CD 19 binding agents for treating disease.
    Type: Grant
    Filed: October 17, 2008
    Date of Patent: June 28, 2011
    Assignee: Seattle Genetics, Inc.
    Inventors: Charlotte McDonagh, Charles G. Cerveny, Dennis Benjamin, Paul Carter
  • METHODS FOR SYNTHESIS OF ENCODED LIBRARIES
    Publication number: 20110136697
    Abstract: The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.
    Type: Application
    Filed: February 9, 2011
    Publication date: June 9, 2011
    Applicant: Praecis Pharmaceuticals Incorporated
    Inventors: Barry MORGAN, Stephen Hale, Christopher C. Arico-Muendel, Matthew Clark, Richard Wagner, David I. Israel, Malcolm L. Gefter, Dennis Benjamin, Nils Jakob Vest Hansen, Malcolm J. Kavarana, Steffen Phillip Creaser, George J. Franklin, Paolo A. Centrella, Raksha A. Acharya
  • Methods for synthesis of encoded libraries
    Patent number: 7935658
    Abstract: The present invention provides methods of synthesizing libraries of molecules comprising a functional moiety which is operatively linked to an encoding oligonucleotide.
    Type: Grant
    Filed: October 4, 2007
    Date of Patent: May 3, 2011
    Assignee: Praecis Pharmaceuticals, Inc.
    Inventors: Barry Morgan, Stephen Hale, Christopher C. Arico-Muendel, Matthew Clark, Richard Wagner, David I. Israel, Malcolm L. Gefter, Dennis Benjamin, Nils Jakob Vest Hansen, Malcolm J. Kavarana, Steffen Phillip Creaser, George J. Franklin, Paolo A. Centrella, Raksha A. Acharya
  • ANTIBODY DRUG CONJUGATES (ADC) THAT BIND TO 24P4C12 PROTEINS
    Publication number: 20100330107
    Abstract: Antibody drug conjugates (ADC's) that bind to 24P4C12 protein and variants thereof are described herein. 24P4C12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
    Type: Application
    Filed: March 5, 2010
    Publication date: December 30, 2010
    Applicants: AGENSYS, INC., SEATTLE GENETICS
    Inventors: Jean Gudas, Aya Jakobovits, Zili An, Robert Kendall Morrison, Karen Jane Meyrick Morrison, Xiao-chi Jia, Dennis Benjamin, Ruth Moser, Peter Senter
  • CD19 Binding Agents and Uses Thereof
    Publication number: 20090136526
    Abstract: This invention, inter alia, relates to CD19 binding agents and methods of using such CD19 binding agents for treating disease.
    Type: Application
    Filed: October 17, 2008
    Publication date: May 28, 2009
    Applicant: Seattle Genetics, Inc.
    Inventors: Charlotte McDonagh, Charles G. Cerveny, Dennis Benjamin, Paul Carter, Hans-Peter Gerber, Leigh Francisco
  • Methods for synthesis of encoded libraries
    Publication number: 20090062147
    Abstract: The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.
    Type: Application
    Filed: October 4, 2007
    Publication date: March 5, 2009
    Applicant: Praecis Pharmaceuticals Incorporated
    Inventors: Barry Morgan, Stephen Hale, Christopher C. Arico-Muendel, Matthew Clark, Richard Wagner, David I. Israel, Malcolm L. Gefter, Dennis Benjamin, Nils Jakob Vest Hansen, Malcolm J. Kavarana, Steffen Phillip Creaser, George J. Franklin, Paolo A. Centrella, Raksha A. Acharya
  • Compositions, kits, and methods for identification, assessment, prevention, and therapy of endometriosis
    Publication number: 20080241852
    Abstract: The invention relates to newly discovered marker polypeptides associated with endometriosis. Compositions, kits, and methods for detecting, characterizing, preventing, and treating endometriosis are provided.
    Type: Application
    Filed: May 9, 2007
    Publication date: October 2, 2008
    Applicant: Praecis Pharmaceuticals Incorporated
    Inventors: Jeffrey Messer, Dennis Benjamin, James Vath, Eric Sigel