Abstract: Provided herein are nucleic acid trans-splicing molecules (e.g., pre-mRNA trans-splicing molecules (RTMs); RNA exon editing molecules) capable of correcting mutations in the ABCA4 gene. Such molecules are useful in the treatment of disorders such as ABCA4-associated retinal dystrophies (e.g., Stargardt Disease or cone-rod dystrophy). Also described herein are methods of using the nucleic acid trans-splicing molecules described herein to correct mutations in ABCA4, thereby treating disorders associated with mutations in ABCA4 and use of the nucleic acid trans-splicing molecules described herein for treating disorders associated with mutations in ABCA4 and in the preparation of medicaments for the treatment of disorders associated with mutations in ABCA4.

Abstract: A modular image capture booth with a plurality of frame members having horizontal and vertical members for assembly into a frame for the modular image capture booth. Each of a plurality of panels attaches to the frame. The plurality of panels forms walls and a ceiling for the modular image capture booth. Each panel has openings adapted to receive a digital camera. Each panel includes a router, and includes one or more lighting fixtures, and wiring from each opening in the panel to the router. The wiring is arranged to connect each digital camera to the router. An image processing computer is connected to of each router. The image processing computer processes the image recorded by each camera to construct a three-dimensional image of an object in the modular image capture booth. In a particular embodiment the modular image capture booth is made from a plurality of interlocking panels.