Patents by Inventor Dennis C. Dean

Dennis C. Dean has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Radioligand and binding assay
    Patent number: 6838291
    Abstract: The present invention is directed to the radioligand compound, [35S]-radiolabeled (+)-N-[1?-(6-cyano-1,2,3,4-tetrahydro-2(R)-naphthalenyl)-3,4-dihydro-4(R)-hydoxyspiro[2H-1-benzopyran-2,4?-piperidin]-6-yl]methanesulfonamide. Also within the scope of this invention is a method for identifying compounds that bind to the IKr channel, and may have antiarrhythmic activity.
    Type: Grant
    Filed: July 12, 2001
    Date of Patent: January 4, 2005
    Assignee: Merck & Co., Inc.
    Inventors: John W. Butcher, David A. Claremon, Thomas M. Connolly, Jerzy Karczewski, Kenneth S. Koblan, Matthew J. Kostura, Nigel J. Liverton, Dennis C. Dean, David G. Melillo
  • Investigational compounds
    Patent number: 6753410
    Abstract: The present invention is directed to compounds and pharmaceutical compositions comprising the compounds which are inhibitors of the enzyme gamma secretase and which are useful in the treatment or prevention of diseases in which the beta-amyloid peptide is involved, such as Alzheimer's disease.
    Type: Grant
    Filed: March 2, 2001
    Date of Patent: June 22, 2004
    Assignee: Merck & Co., Inc.
    Inventors: Alan John Nadin, Joseph George Neduvelil, Mohinder K. Sardana, Jules A. Shafer, Stephen J. Gardell, Ming-Tain Lai, Yueming Li, Bruce D. Dorsey, Dennis C. Dean
  • Radioligand and binding assay
    Publication number: 20020034730
    Abstract: The present invention is directed to the radioligand compound, [35S]-radiolabeled (+)-N-[1′-(6-cyano-1,2,3,4-tetrahydro-2(R)-naphthalenyl)-3,4-dihydro-4(R)-hydoxyspiro[2H-1-benzopyran-2,4′-piperidin]-6-yl]methanesulfonamide. Also within the scope of this invention is a method for identifying compounds that bind to the IKr channel, and may have antiarrhythmic activity.
    Type: Application
    Filed: July 12, 2001
    Publication date: March 21, 2002
    Inventors: John W. Butcher, David A. Claremon, Thomas M. Connolly, Jerzy Karczewski, Kenneth S. Koblan, Matthew J. Kostura, Nigel J. Liverton, Dennis C. Dean, David G. Melillo
  • Investigational compounds
    Publication number: 20020013276
    Abstract: The present invention provides a compound of formula I or a salt thereof: 1
    Type: Application
    Filed: March 2, 2001
    Publication date: January 31, 2002
    Inventors: Alan John Nadin, Joseph George Neduvelil, Mohinder K. Sardana, Jules A. Shafer, Stephen J. Gardell, Ming-Tain Lai, Yueming Li, Bruce D. Dorsey, Dennis C. Dean
  • Radiolabeled growth hormone secretagogue
    Patent number: 5830433
    Abstract: The present invention is directed to ?.sup.35 S!-N-?1(R)-?(1,2-dihydro-1-methanesulfonylspiro?3H-indole-3,4'-piperidin!- 1'-yl)carbonyl!-2-(phenylmethyloxy)ethyl!-2-amino-2-methylpropanamide, and pharmaceutically acceptable salts thereof. This ?.sup.35 S! radioligand is useful in identifying and characterizing cellular receptors which play a role in the activity of growth hormone secretatogogues. In addition, this ?.sup.35 S! radioligand is useful in assays which test compounds for growth hormone secretagogue activity.
    Type: Grant
    Filed: December 17, 1996
    Date of Patent: November 3, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Dennis C. Dean, David G. Melillo, Ravi Nargund, Leonardus Van Der Ploeg, Sheng-Shung Pong, James M. Schaeffer, Roy G. Smith
  • Bis-acyloxymethyl derivatives
    Patent number: 5583148
    Abstract: This invention relates to new pyridyl, quinoline and acridine bis-acyloxymethyl compounds; to compositions comprising these compounds; and to processes for their utility as fungicides, bactericides and as inhibitors of the growth of cancer in warm-blooded animals.
    Type: Grant
    Filed: July 15, 1991
    Date of Patent: December 10, 1996
    Assignee: Research Foundation Of State University Of New York
    Inventors: Wayne K. Anderson, Dennis C. Dean