Patents by Inventor Dennis Carson

Dennis Carson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240382570
    Abstract: Disclosed is a hydrogel comprising a hydrophilic gelling agent that includes a nonionic cellulose ether, and active thermolysin, wherein the proteolytic activity of the thermolysin does not decrease by more than 20% when stored at room temperature for 6 months.
    Type: Application
    Filed: May 17, 2024
    Publication date: November 21, 2024
    Applicant: SMITH & NEPHEW, INC.
    Inventors: Lei SHI, Aleksa JOVANOVIC, Dennis CARSON
  • Publication number: 20240382433
    Abstract: Disclosed is a dissolvable, gel-forming film, and methods for its use, comprising a water-soluble cellulose ether, a hydrophilic rheological modifying agent, and an active proteolytic enzyme or other drug substance. The gel-forming film has a water content of less than 15% w/w and is capable of forming a hydrogel when contacted with water or other aqueous medium. The disclosed films achieve delivery of stable proteolytic enzymes to the desired site of action in a manner that provides uniform delivery of the enzymes.
    Type: Application
    Filed: May 17, 2024
    Publication date: November 21, 2024
    Applicant: SMITH & NEPHEW, INC.
    Inventors: Lei SHI, Aleksa JOVANOVIC, Dennis CARSON
  • Patent number: 12091393
    Abstract: Compounds of formulae (I)-(VD): A1-Q-L1-A2-L2-Z??Formula I are useful for enhancing or prolonging an immune response, such as, in a vaccine as an adjuvant or a co-adjuvant.
    Type: Grant
    Filed: October 22, 2019
    Date of Patent: September 17, 2024
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Dennis Carson, Mary Patricia Corr, Howard B. Cottam, Tomoko Hayashi, Nikunj Shukla
  • Patent number: 12023412
    Abstract: Disclosed is a dissolvable, gel-forming film, and methods for its use, comprising a water-soluble cellulose ether, a hydrophilic rheological modifying agent, and an active proteolytic enzyme or other drug substance. The gel-forming film has a water content of less than 15% w/w and is capable of forming a hydrogel when contacted with water or other aqueous medium. The disclosed films achieve delivery of stable proteolytic enzymes to the desired site of action in a manner that provides uniform delivery of the enzymes.
    Type: Grant
    Filed: August 22, 2022
    Date of Patent: July 2, 2024
    Assignee: SMITH & NEPHEW, INC.
    Inventors: Lei Shi, Aleksa Jovanovic, Dennis Carson
  • Patent number: 12016907
    Abstract: Disclosed is a hydrogel comprising a hydrophilic gelling agent that includes a nonionic cellulose ether, and active thermolysin, wherein the proteolytic activity of the thermolysin does not decrease by more than 20% when stored at room temperature for 6 months.
    Type: Grant
    Filed: August 15, 2022
    Date of Patent: June 25, 2024
    Assignee: SMITH & NEPHEW, INC.
    Inventors: Lei Shi, Aleksa Jovanovic, Dennis Carson
  • Publication number: 20230055292
    Abstract: Disclosed is a dissolvable, gel-forming film, and methods for its use, comprising a water-soluble cellulose ether, a hydrophilic rheological modifying agent, and an active proteolytic enzyme or other drug substance. The gel-forming film has a water content of less than 15% w/w and is capable of forming a hydrogel when contacted with water or other aqueous medium. The disclosed films achieve delivery of stable proteolytic enzymes to the desired site of action in a manner that provides uniform delivery of the enzymes.
    Type: Application
    Filed: August 22, 2022
    Publication date: February 23, 2023
    Inventors: Lei SHI, Aleksa JOVANOVIC, Dennis CARSON
  • Publication number: 20230031268
    Abstract: Disclosed is a hydrogel comprising a hydrophilic gelling agent that includes a nonionic cellulose ether, and active thermolysin, wherein the proteolytic activity of the thermolysin does not decrease by more than 20% when stored at room temperature for 6 months.
    Type: Application
    Filed: August 15, 2022
    Publication date: February 2, 2023
    Inventors: Lei Shi, Aleksa Jovanovic, Dennis Carson
  • Patent number: 11452698
    Abstract: Disclosed is a dissolvable, gel-forming film, and methods for its use, comprising a water-soluble cellulose ether, a hydrophilic rheological modifying agent, and an active proteolytic enzyme or other drug substance. The gel-forming film has a water content of less than 15% w/w and is capable of forming a hydrogel when contacted with water or other aqueous medium. The disclosed films achieve delivery of stable proteolytic enzymes to the desired site of action in a manner that provides uniform delivery of the enzymes.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: September 27, 2022
    Assignee: SMITH & NEPHEW, INC.
    Inventors: Lei Shi, Aleksa Jovanovic, Dennis Carson
  • Patent number: 11446364
    Abstract: Disclosed is a hydrogel comprising a hydrophilic gelling agent that includes a nonionic cellulose ether, and active thermolysin, wherein the proteolytic activity of the thermolysin does not decrease by more than 20% when stored at room temperature for 6 months.
    Type: Grant
    Filed: November 14, 2013
    Date of Patent: September 20, 2022
    Assignee: SMITH & NEPHEW, INC.
    Inventors: Lei Shi, Aleksa Jovanovic, Dennis Carson
  • Publication number: 20210380546
    Abstract: Compounds useful as an adjuvant, e.g., formulas (I)-(VI) and uses thereof, for example, with immunogenic moieties or other adjuvants, are provided.
    Type: Application
    Filed: October 22, 2019
    Publication date: December 9, 2021
    Inventors: Dennis Carson, Mary Patricia Corr, Howard B. Cottam, Tomoko Hayashi, Nikunj Shukla
  • Patent number: 10766962
    Abstract: The present invention is directed to antibodies and fragments thereof having binding specificity for FZD7, which preferably do not substantially interact with (bind to) other FZD family members, and methods of making said anti-FZD7 antibodies and binding fragments thereof. Another embodiment relates to antibodies and binding fragments comprising sequences of VH, VL and/or CDR polypeptides described herein. The invention also contemplates conjugates of anti-FZD7 antibodies and binding fragments. The invention further contemplates use of anti-FZD7 antibodies and binding fragments for tissue engineering. This invention also relates to a transgenic mouse expressing the epitope of anti-FZD7 antibodies and binding fragments thereof. Embodiments also pertain to use of anti-FZD7 antibodies and binding fragments (as well as the identified FZD7 epitope) for diagnosis, assessment, prevention and/or treatment of diseases and disorders associated with aberrant FZD7 expression, such as cancer.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: September 8, 2020
    Assignee: The Regents of the University of California
    Inventors: Karl Willert, Dennis Carson
  • Patent number: 10206982
    Abstract: Wound debridement compositions containing the proteolytic enzyme Seaprose and use of such compositions in wound treatment for the enzymatic debridement of wounds.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: February 19, 2019
    Assignee: SMITH & NEPHEW ORTHOPAEDICS AG
    Inventors: Lei Shi, Aleksa Jovanovic, Dennis Carson
  • Publication number: 20180186885
    Abstract: The present invention is directed to antibodies and fragments thereof having binding specificity for FZD7, which preferably do not substantially interact with (bind to) other FZD family members, and methods of making said anti-FZD7 antibodies and binding fragments thereof. Another embodiment relates to antibodies and binding fragments comprising sequences of VH, VL and/or CDR polypeptides described herein. The invention also contemplates conjugates of anti-FZD7 antibodies and binding fragments. The invention further contemplates use of anti-FZD7 antibodies and binding fragments for tissue engineering. This invention also relates to a transgenic mouse expressing the epitope of anti-FZD7 antibodies and binding fragments thereof. Embodiments also pertain to use of anti-FZD7 antibodies and binding fragments (as well as the identified FZD7 epitope) for diagnosis, assessment, prevention and/or treatment of diseases and disorders associated with aberrant FZD7 expression, such as cancer.
    Type: Application
    Filed: June 16, 2016
    Publication date: July 5, 2018
    Inventors: Karl WILLERT, Dennis CARSON
  • Publication number: 20170136103
    Abstract: Wound debridement compositions containing the proteolytic enzyme Seaprose and use of such compositions in wound treatment for the enzymatic debridement of wounds.
    Type: Application
    Filed: January 27, 2017
    Publication date: May 18, 2017
    Inventors: Lei SHI, Aleksa JOVANOVIC, Dennis CARSON
  • Publication number: 20160008293
    Abstract: Disclosed is a dissolvable, gel-forming film, and methods for its use, comprising a water-soluble cellulose ether, a hydrophilic rheological modifying agent, and an active proteolytic enzyme or other drug substance. The gel-forming film has a water content of less than 15% w/w and is capable of forming a hydrogel when contacted with water or other aqueous medium. The disclosed films achieve delivery of stable proteolytic enzymes to the desired site of action in a manner that provides uniform delivery of the enzymes.
    Type: Application
    Filed: March 12, 2014
    Publication date: January 14, 2016
    Inventors: Lei SHI, Aleksa JOVANOVIC, Dennis CARSON
  • Publication number: 20150283217
    Abstract: Disclosed is a hydrogel comprising a hydrophilic gelling agent that includes a nonionic cellulose ether, and active thermolysin, wherein the proteolytic activity of the thermolysin does not decrease by more than 20% when stored at room temperature for 6 months.
    Type: Application
    Filed: November 14, 2013
    Publication date: October 8, 2015
    Inventors: Lei Shi, Aleksa Jovanovic, Dennis Carson
  • Patent number: 9045401
    Abstract: The invention provides novel compositions—lipopeptides and analogs, including somocystinamide A, and somocystinamide A variants and analogs, and pharmaceutical compositions, liposomes and nanoparticles comprising them, and methods of making and using them. In one embodiment, these lipopeptides and analogs are used to induce apoptosis in a cell, which can be a normal cell, a dysfunctional cell and/or a cancer (tumor) cell. In alternative embodiments, the compositions of the invention, including the lipopeptides and analogs of the invention, and the pharmaceutical compositions comprising them, are used to treat or ameliorate (including slowing the progression of) normal, dysfunctional (e.g., abnormally proliferating) and/or tumor associated blood vessels, including endothelial and/or capillary cell growth; including neovasculature related to (within, providing a blood supply to) a tumor.
    Type: Grant
    Filed: May 21, 2008
    Date of Patent: June 2, 2015
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: William Gerwick, Wolfgang Wrasidlo, Dennis Carson, Dwayne Stupack, Takashi Suyama
  • Patent number: 8932447
    Abstract: Devices and techniques are described that involve a combination of multidimensional electrokinetic, dielectrophoretic, electrophoretic and fluidic forces and effects for separating cells, nanovesicles, nanoparticulates and biomarkers (DNA, RNA, antibodies, proteins) in high conductance (ionic) strength biological samples and buffers. In disclosed embodiments, a combination of continuous and/or pulsed dielectrophoretic (DEP) forces, continuous and/or pulsed field DC electrophoretic forces, microelectrophoresis and controlled fluidics are utilized with arrays of electrodes. In particular, the use of chambered DEP devices and of a properly scaled relatively larger electrode array devices that combines fluid, electrophoretic and DEP forces enables both larger and/or clinically relevant volumes of blood, serum, plasma or other samples to be more directly, rapidly and efficiently analyzed. The invention enables the creation of “seamless” sample-to-answer diagnostic systems and devices.
    Type: Grant
    Filed: October 25, 2013
    Date of Patent: January 13, 2015
    Assignee: The Regents of the University of California
    Inventors: Michael Heller, Benjamin Sullivan, Rajaram Krishnan, Dennis Carson, Sadik C. Esener
  • Publication number: 20140154235
    Abstract: Wound debridement compositions containing the proteolytic enzyme Seaprose and use of such compositions in wound treatment for the enzymatic debridement of wounds.
    Type: Application
    Filed: May 11, 2012
    Publication date: June 5, 2014
    Applicant: SMITH & NEPHEW ORTHOPAEDICS AG
    Inventors: Lei Shi, Aleksa Jovanovic, Dennis Carson
  • Publication number: 20140048417
    Abstract: Devices and techniques are described that involve a combination of multidimensional electrokinetic, dielectrophoretic, electrophoretic and fluidic forces and effects for separating cells, nanovesicles, nanoparticulates and biomarkers (DNA, RNA, antibodies, proteins) in high conductance (ionic) strength biological samples and buffers. In disclosed embodiments, a combination of continuous and/or pulsed dielectrophoretic (DEP) forces, continuous and/or pulsed field DC electrophoretic forces, microelectrophoresis and controlled fluidics are utilized with arrays of electrodes. In particular, the use of chambered DEP devices and of a properly scaled relatively larger electrode array devices that combines fluid, electrophoretic and DEP forces enables both larger and/or clinically relevant volumes of blood, serum, plasma or other samples to be more directly, rapidly and efficiently analyzed. The invention enables the creation of “seamless” sample-to-answer diagnostic systems and devices.
    Type: Application
    Filed: October 25, 2013
    Publication date: February 20, 2014
    Applicant: The Regents of the University of California
    Inventors: Michael Heller, Benjamin Sullivan, Rajaram Krishnan, Dennis Carson, Sadik C. Esener