Abstract: The use of a three-way combination of additives comprising (B)(i) a metal (C10 to C40)hydrocarbyl-substituted hydroxybenzoate detergent; (B)(ii) a poly(C2 to C6)alkenyl-substituted anhydride or poly(C2 to C6)alkenyl-substituted acid; and (B)(iii) an aliphatic hydrocarbyl acid amide, or an aliphatic hydrocarbyl acid imide, or a combination thereof, to inhibit asphaltene precipitation from crude oil.

Abstract: Compounds, pharmaceutically acceptable salts, stereoisomers and prodrugs thereof, that are ER ligands and particularly to such compounds that are ER beta-selective and/or ER beta-specific ligands. Compounds herein include certain compounds which are ER beta-selective agonists. Compounds herein include ER beta-selective agonists which exhibit minimal agonist or antagonist effect on ER alpha. Compounds of the invention include those of formula I: and any pharmaceutically acceptable salts, stereoisomers and prodrugs thereof wherein AR, R1, R3, and X1—X4 are as defined hereinabove.