Patents by Inventor Dennis E. Hallahan

Dennis E. Hallahan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions targeting radiation-induced molecules and methods of use thereof
    Patent number: 10449261
    Abstract: The present invention is directed towards the compositions of peptide constructs that bind to GRP78 and the methods of use thereof.
    Type: Grant
    Filed: July 24, 2015
    Date of Patent: October 22, 2019
    Assignee: WASHINGTON UNIVERSITY
    Inventor: Dennis E. Hallahan
  • Antibodies to GRP78
    Patent number: 10259884
    Abstract: The present invention is directed towards isolated antibodies that bind to GRP78.
    Type: Grant
    Filed: June 20, 2017
    Date of Patent: April 16, 2019
    Assignees: Washington University, Vanderbilt University
    Inventors: Dennis E. Hallahan, Heping Yan
  • Ligands to radiation-induced molecules
    Patent number: 10086073
    Abstract: A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. In some embodiments, the method includes the steps of (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more molecules of the library of diverse molecules, whereby a molecule that binds an irradiated tumor is identified. Also provided are targeting ligands that bind an irradiated tumor and therapeutic and diagnostic methods that employ the disclosed targeting ligands.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: October 2, 2018
    Assignee: WASHINGTON UNIVERSITY
    Inventors: Dennis E. Hallahan, Shimian Qu, Zhaozhong Han
  • Monoclonal antibodies to human 14-3-3 epsilon and human 14-3-3 epsilon sv
    Patent number: 10066008
    Abstract: The present invention provides isolated antibodies that bind to 14-3-3 epsilon that are useful in the recognition of tumor cells and tumor specific delivery of drugs and therapies.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: September 4, 2018
    Assignee: WASHINGTON UNIVERSITY
    Inventors: Dennis E. Hallahan, Heping Yan
  • ANTIBODIES TO TIP-1 AND GRP78
    Publication number: 20170298142
    Abstract: The present invention is directed towards isolated antibodies that bind to GRP78.
    Type: Application
    Filed: June 20, 2017
    Publication date: October 19, 2017
    Inventors: Dennis E. Hallahan, Heping Yan
  • Antibodies to TIP-1
    Patent number: 9738725
    Abstract: The present invention is directed towards isolated antibodies that bind to GRP78 and TIP-1.
    Type: Grant
    Filed: January 28, 2014
    Date of Patent: August 22, 2017
    Assignees: WASHINGTON UNIVERSITY, VANDERBILT UNIVERSITY
    Inventors: Dennis E. Hallahan, Heping Yan
  • COMPOSITIONS TARGETING RADIATION-INDUCED MOLECULES AND METHODS OF USE THEREOF
    Publication number: 20170209603
    Abstract: The present invention is directed towards the compositions of peptide constructs that bind to GRP78 and the methods of use thereof.
    Type: Application
    Filed: July 24, 2015
    Publication date: July 27, 2017
    Inventor: Dennis E. Hallahan
  • LIGANDS TO RADIATION-INDUCED MOLECULES
    Publication number: 20160206736
    Abstract: A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. In some embodiments, the method includes the steps of (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more molecules of the library of diverse molecules, whereby a molecule that binds an irradiated tumor is identified. Also provided are targeting ligands that bind an irradiated tumor and therapeutic and diagnostic methods that employ the disclosed targeting ligands.
    Type: Application
    Filed: April 8, 2016
    Publication date: July 21, 2016
    Applicants: Vanderbilt University, Washington University
    Inventors: Dennis E. Hallahan, Shimian Qu, Zhaozhong Han
  • MONOCLONAL ANTIBODIES TO HUMAN 14-3-3 EPSILON AND HUMAN 14-3-3 EPSILON SV
    Publication number: 20160194388
    Abstract: The present invention provides isolated antibodies that bind to 14-3-3 epsilon that are useful in the recognition of tumor cells and tumor specific delivery of drugs and therapies.
    Type: Application
    Filed: February 26, 2016
    Publication date: July 7, 2016
    Inventors: Dennis E. Hallahan, Heping Yan
  • Ligands to radiation-induced molecules
    Patent number: 9340581
    Abstract: A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. In some embodiments, the method includes the steps of (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more molecules of the library of diverse molecules, whereby a molecule that binds an irradiated tumor is identified. Also provided are targeting ligands that bind an irradiated tumor and therapeutic and diagnostic methods that employ the disclosed targeting ligands.
    Type: Grant
    Filed: June 18, 2014
    Date of Patent: May 17, 2016
    Assignee: WASHINGTON UNIVERSITY
    Inventors: Dennis E. Hallahan, Shimian Qu, Zhaozhong Han
  • Phage antibodies to radiation-inducible neoantigens
    Patent number: 8927288
    Abstract: A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. The method includes the steps of: (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more molecules of the library of diverse molecules, whereby a molecule that binds an irradiated tumor is identified. Also provided are therapeutic and diagnostic methods using targeting ligands that bind an irradiated tumor.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: January 6, 2015
    Assignee: Vanderbilt University
    Inventors: Dennis E. Hallahan, Raymond Mernaugh
  • LIGANDS TO RADIATION-INDUCED MOLECULES
    Publication number: 20140369929
    Abstract: A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. In some embodiments, the method includes the steps of (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more molecules of the library of diverse molecules, whereby a molecule that binds an irradiated tumor is identified. Also provided are targeting ligands that bind an irradiated tumor and therapeutic and diagnostic methods that employ the disclosed targeting ligands.
    Type: Application
    Filed: June 18, 2014
    Publication date: December 18, 2014
    Applicant: VANDERBILT UNIVERSITY
    Inventors: Dennis E. Hallahan, Shimian Qu, Zhaozhong Han
  • ANTIBODIES TO TIP-1 AND GRP78
    Publication number: 20140316186
    Abstract: The present invention is directed towards isolated antibodies that bind to GRP78 and TIP-1.
    Type: Application
    Filed: January 28, 2014
    Publication date: October 23, 2014
    Inventors: Dennis E. Hallahan, Heping Yan
  • Use of GSK3 inhibitors in combination with radiation therapies
    Patent number: 8771754
    Abstract: The presently disclosed subject matter relates generally to the fields of molecular biology and medicine. More particularly, it concerns methods involving the use of GSK3 inhibitors in combination with radiation therapies. In some embodiments, administration of a GSK3 inhibitor to a subject results in an amelioration of cognitive decline, toxicity to vascular endothelial cells, and/or neuron death associated with radiation therapy alone.
    Type: Grant
    Filed: September 19, 2005
    Date of Patent: July 8, 2014
    Assignee: Vanderbilt University
    Inventor: Dennis E. Hallahan
  • Ligands to radiation-induced molecules
    Patent number: 8765097
    Abstract: A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. In some embodiments, the method includes the steps of (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more molecules of the library of diverse molecules, whereby a molecule that binds an irradiated tumor is identified. Also provided are targeting ligands that bind an irradiated tumor and therapeutic and diagnostic methods that employ the disclosed targeting ligands.
    Type: Grant
    Filed: February 13, 2013
    Date of Patent: July 1, 2014
    Assignees: Washington University, Vanderbilt University
    Inventors: Dennis E. Hallahan, Shimian Qu, Zhaozhong Han
  • Specific inhibition of cPLAenhances the efficacy of radiotherapy
    Patent number: 8740762
    Abstract: A method for increasing the radiosensitivity of a target tissue in a subject is disclosed. In some embodiments, the methods includes administering a cytosolic phospholipase A2 (cPLA2) antagonist to the subject, whereby the radiosensitivity of the target tissue is increased. Also disclosed are methods for suppressing tumor growth in a subject and methods for inhibiting tumor blood vessel growth.
    Type: Grant
    Filed: April 7, 2008
    Date of Patent: June 3, 2014
    Assignee: Vanderbilt University
    Inventors: Dennis E. Hallahan, Eugenia M. Yazlovitskaya
  • PHAGE ANTIBODIES TO RADIATION-INDUCIBLE NEOANTIGENS
    Publication number: 20140088408
    Abstract: A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. The method includes the steps of: (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more molecules of the library of diverse molecules, whereby a molecule that binds an irradiated tumor is identified. Also provided are therapeutic and diagnostic methods using targeting ligands that bind an irradiated tumor.
    Type: Application
    Filed: November 27, 2013
    Publication date: March 27, 2014
    Inventors: Dennis E. Hallahan, Raymond Mernaugh
  • Phage antibodies to radiation-inducible neoantigens
    Patent number: 8617521
    Abstract: A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. The method includes the steps of: (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more molecules of the library of diverse molecules, whereby a molecule that binds an irradiated tumor is identified. Also provided are therapeutic and diagnostic methods using targeting ligands that bind an irradiated tumor.
    Type: Grant
    Filed: August 1, 2011
    Date of Patent: December 31, 2013
    Assignee: Vanderbilt University
    Inventors: Dennis E. Hallahan, Raymond Mernaugh
  • LIGANDS TO RADIATION-INDUCED MOLECULES
    Publication number: 20130251628
    Abstract: A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. In some embodiments, the method includes the steps of (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more molecules of the library of diverse molecules, whereby a molecule that binds an irradiated tumor is identified. Also provided are targeting ligands that bind an irradiated tumor and therapeutic and diagnostic methods that employ the disclosed targeting ligands.
    Type: Application
    Filed: February 13, 2013
    Publication date: September 26, 2013
    Applicant: Vanderbilt University
    Inventors: Dennis E. Hallahan, Shimian Qu, Zhaozhong Han
  • Ligands to radiation-induced molecules
    Patent number: 8388932
    Abstract: A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. In some embodiments, the method includes the steps of (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more molecules of the library of diverse molecules, whereby a molecule that binds an irradiated tumor is identified. Also provided are targeting ligands that bind an irradiated tumor and therapeutic and diagnostic methods that employ the disclosed targeting ligands.
    Type: Grant
    Filed: February 1, 2011
    Date of Patent: March 5, 2013
    Assignee: Vanderbilt University
    Inventors: Dennis E. Hallahan, Shimian Qu, Zhaozhong Han